Abstract: Disclosed are devices, systems and methods for implantable a biofuel cells. In some aspects, a biofuel cell device for extracting energy from a biological fluid includes a substrate including two compartments each with one or more openings; an anode assembly disposed in the substrate and including an anode electrode and functionalization material to facilitate an oxidative process that releases electrons captured at the anode electrode; and a cathode assembly disposed in the substrate separated from the anode assembly and including a catalytic material facilitate a chemical reduction process such that the biofuel cell device extracts electrical energy from the substance in the biological fluid.

Abstract: Disclosed are platforms to enable lower impedance electrode array, together with a miniaturized battery pack. Lower impedance can be achieved by different approaches, according to the invention, including surface modifications, preferably in nanoscale. Also disclosed are articles and control systems comprising medical implant neural stimulator devices, neural diagnosis tools, spinal cord and peripheral nerve stimulations, and cochlear implants. More particularly, the invention discloses means for reducing pains in human body, utilizing innovative components and systems comprising an epidural lead having multiple electrodes at a distal end, the electrodes being configured in an array and being selectable to provide either unilateral or bilateral neural stimulation.

Abstract: A quantum dot dispersed glass article is disclosed herein and associated articles, products, and methods of making thereof. In an aspect, a glass material can incorporate one or more quantum dot dispersed therein, wherein the one or more quantum dot luminesces upon excitation from an excitation source. In another aspect, the quantum dot can take a variety of shapes and sizes. In another aspect, the quantum dot can be water soluble. In yet another aspect, the quantum dot can be dispersed within one or more glass cavities.

Abstract: The present disclosure provides compositions and methods of treating Breast Cancer. Disclosed is a nanoparticle paired to at least one of W genetic materials that suppress key regulators of fat synthesis (e.g. Rev-erb) to cause a predefined target cell types apoptosis or X predefined targeting moieties that cause predefined target cell types apoptosis and correspond to Y predefined target parameters associated with Z predefined target cell types in connection with treatment of at least one of the following breast cancer, glioblastoma, head and neck cancer, pancreatic cancer, lung cancer, cancer of the nervous system, gastrointestinal cancer, prostate cancer, ovarian cancer, kidney cancer, retina, cancer, skin cancer, liver cancer, genital.

Abstract: The present invention relates to an apparatus to detect biological parameters in the analysis of a sample, specimen, or assay. The system includes a device for determining one or more values for one or more measurable characteristics of a sample. In an aspect, the device can be configured to operate on any of a mobile device, tablet computer, laptop computer, desktop computer, digital pen, medical testing tool or electronic device. In another aspect, the device can comprise a synchronization component that synchronizes the device to a network system.

Abstract: Multiplexed assays are disclosed for detection of duster differentiation 4 (CD4) glycoprotein expressed on the cell surface of I-helper cells, monocytes, macrophages, and dendritic cells; cluster differentiation 25 (CD25), a type transmembrane protein present on activated T-cells, activated B-cells, thymocytes, myeloid precursors, and oligodendrocytes; and Forkhead box P3 (FOXP3), an intracellular protein involved in immune system responses in cell cultures, tissues samples, humans, and biological samples. The multiplexed assays can be used to detect 1r-cells, activated I-cells, and other similar cell types (e.g. natural T regulatory cells, adaptive/induced T regulatory T cells). The multiplexed assays employ quantum dots of various shapes, types, compositions, coatings, sizes, ligands and other such characteristics.

Abstract: Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications.

Abstract: A tetrapod article and its uses are disclosed whereby such tetrapod article comprises an apex base nanomaterial and X leg base nanomaterial protruding from the apex, wherein X is an integer. In an aspect, the tetrapod article can comprise Y nanomaterial layers overcoating the apex base material and the leg base nanomaterial protruding from the apex, wherein Y is an integer. In yet another aspect, disclosed is an assay kit comprising a set of hydrophobic coated tetrapod articles coupled to K pairing moieties that are paired to L predefined targeting items to form a set of tetrapod conjugates that that correspond to M biological parameters and luminesce at respective wavelengths that correspond to the respective predefined target cell types, wherein K, L, and M are integers.

Abstract: The present disclosure provides compositions and methods of treating Alzheimers Disease. In an aspect, a nanoparticle is paired to one or more genetic materials that regulates inflammation in a microenvironment. Such nanoparticles can be used to target predefined target cell types in connection with treatment of at least one of the following Alzheimer's disease, Pick's disease, Lewy Body disease, or Idiopathic dementia.

Abstract: The present disclosure provides compositions and methods of enhancing resistance to viral infections through targeted delivery of 5?PPP negative stranded siRNA via nanoparticles, specifically gold nanorods. The 5?PPP activates type I interferon through the signaling cascade providing a novel therapeutic and prophylactic for seasonal and pandemic influenza. The technology described herein also extends the findings to the use of nanoparticles for delivery of genetic material including but not limited to siRNA and microRNA to accomplish targeted nanoparticle based gene therapy.