Patents by Inventor Kristala Lanett Jones Prather

Kristala Lanett Jones Prather has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microbial system for biosynthesis of natural and engineered products coupled to in situ extraction in supercritical CO
    Patent number: 10941379
    Abstract: Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical CO2, near critical CO2, or liquid CO2.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: March 9, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Janelle Renee Thompson, Kyle C. Peet, Adam J. E. Freedman, Kristala Lanett Jones Prather, Jason Thomas Boock, Michael T. Timko
  • Microbial production of branched medium chain alcohols, such as 4-methylpentanol
    Patent number: 10100335
    Abstract: The invention relates to recombinant cells and their use in in the production of branched medium-chain alcohols such as 4-methyl-1-pentanol.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: October 16, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Kristala Lanett Jones Prather, Micah James Sheppard, Aditya Kunjapur
  • MICROBIAL SYSTEM FOR BIOSYNTHESIS OF NATURAL AND ENGINEERED PRODUCTS COUPLED TO IN SITU EXTRACTION IN SUPERCRITICAL CO2
    Publication number: 20180119089
    Abstract: Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical CO2, near critical CO2, or liquid CO2.
    Type: Application
    Filed: May 9, 2017
    Publication date: May 3, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Janelle Renee Thompson, Kyle C. Peet, Adam J.E. Freedman, Kristala Lanett Jones Prather, Jason Thomas Boock, Michael T. Timko
  • DYNAMIC KNOCKDOWN OF CENTRAL METABOLISM FOR REDIRECTING GLUCOSE-6-PHOSPHATE FLUXES
    Publication number: 20170130210
    Abstract: Described herein are methods for dynamic redirection of metabolic flux in a cell from central metabolism towards production of heterologous products.
    Type: Application
    Filed: June 9, 2015
    Publication date: May 11, 2017
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Irene Marie BROCKMAN, Kristala Lanett Jones PRATHER, Apoorv GUPTA
  • MICROBIAL PRODUCTION OF BRANCHED MEDIUM CHAIN ALCOHOLS, SUCH AS 4-METHYLPENTANOL
    Publication number: 20150132816
    Abstract: The invention relates to recombinant cells and their use in the production of branched medium-chain alcohols such as 4-methyl-1-pentanol.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 14, 2015
    Inventors: Kristala Lanett Jones Prather, Micah James Sheppard, Aditya Kunjapur
  • CELLULAR PRODUCTION OF GLUCARIC ACID
    Publication number: 20150093794
    Abstract: The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate dehydrogenase. Cloning and characterization of the gene encoding uronate dehydrogenase is also disclosed.
    Type: Application
    Filed: August 5, 2014
    Publication date: April 2, 2015
    Inventors: TAE SEOK MOON, Sang-Hwal Yoon, Kristala Lanett Jones Prather
  • MICROBIAL PRODUCTION OF 3,4-DIHYDROXYBUTYRATE (3,4-DHBA), 2,3- DIHYDROXYBUTYRATE (2,3-DHBA) AND 3-HYDROXYBUTYROLACTONE (3-HBL)
    Publication number: 20140364629
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: March 5, 2014
    Publication date: December 11, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • Cellular production of glucaric acid through recombinant expression of uronate dehydrogenase and myo-inositol oxygenase
    Patent number: 8835147
    Abstract: The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate dehydrogenase. Cloning and characterization of the gene encoding uronate dehydrogenase is also disclosed.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: September 16, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Tae Seok Moon, Sang-Hwal Yoon, Kristala Lanett Jones Prather
  • Glucose valve and other metabolite valves
    Patent number: 8835138
    Abstract: Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: September 16, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Kevin Solomon, Tae Seok Moon, Kristala Lanett Jones Prather
  • Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL)
    Patent number: 8669379
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 11, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • GLUCOSE VALVE AND OTHER METABOLITE VALVES
    Publication number: 20130071894
    Abstract: Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.
    Type: Application
    Filed: March 30, 2011
    Publication date: March 21, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Kevin Solomon, Tae Seok Moon, Kristala Lanett Jones Prather
  • Microbial production of 3-hydroxyacids from glucose and glycolate
    Patent number: 8361760
    Abstract: The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: January 29, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Collin Hunter Martin, Kristala Lanett Jones Prather
  • METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDS
    Publication number: 20120315672
    Abstract: The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
    Type: Application
    Filed: November 10, 2010
    Publication date: December 13, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Effendi Leonard, Parayil K. Ajikumar, Kristala Lanett Jones Prather, Gregory Stephanopoulos, Kelly Thayer
  • MICROBIAL PRODUCTION OF PENTANOL FROM GLUCOSE OR GLYCEROL
    Publication number: 20120288909
    Abstract: The invention relates to the production of pentanol through recombinant gene expression and metabolic engineering.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 15, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Hsien-Chung TSENG, Kristala Lanett Jones Prather
  • MICROBIAL PRODUCTION OF 3,4-DIHYDROXYBUTYRATE (3,4-DHBA), 2,3- DIHYDROXYBUTYRATE (2,3-DHBA) AND 3-HYDROXYBUTYROLACTONE (3-HBL)
    Publication number: 20120226055
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 6, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • Methods for microbial production of terpenoids
    Patent number: 8062878
    Abstract: The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: November 22, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Effendi Leonard, Parayil K. Ajikumar, Kristala Lanett Jones Prather, Gregory Stephanopoulos, Kelly Thayer
  • CELLULAR PRODUCTION OF GLUCARIC ACID
    Publication number: 20110124065
    Abstract: The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate dehydrogenase. Cloning and characterization of the gene encoding uronate dehydrogenase is also disclosed.
    Type: Application
    Filed: April 3, 2009
    Publication date: May 26, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Tae Seok Moon, Sang-Hwal Yoon, Kristala Lanett Jones Prather
  • METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDS
    Publication number: 20110111457
    Abstract: The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
    Type: Application
    Filed: November 10, 2009
    Publication date: May 12, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: EFFENDI LEONARD, PARAYIL K. AJIKUMAR, KRISTALA LANETT JONES PRATHER, GREGORY STEPHANOPOULOS, KELLY THAYER
  • CELLULAR PRODUCTION OF HYDROXYVALERATES FROM LEVULINATE
    Publication number: 20110086398
    Abstract: The invention relates to cells that recombinantly express tesB and produce one or more hydroxyacids such as 3-hydroxyvalerate (3HV) and/or 4-hydroxyvalerate (4HV).
    Type: Application
    Filed: April 3, 2009
    Publication date: April 14, 2011
    Inventors: Collin Hunter Martin, Kristala Lanett Jones Prather
  • MICROBIAL PRODUCTION OF 3-HYDROXYACIDS FROM GLUCOSE AND GLYCOLATE
    Publication number: 20100255549
    Abstract: The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: March 5, 2010
    Publication date: October 7, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Collin Hunter Martin, Kristala Lanett Jones Prather