Patents by Inventor Kristi L. Kiick
Kristi L. Kiick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11628239Abstract: Skeletonized blood vessels for use as vascular grafts are protected from biomechanical injury and/or certain cellular and extracellular changes by application of a biocompatible hydrogel to the vessel exterior. The hydrogel may be applied to the vessel graft before or after harvesting from a donor patient.Type: GrantFiled: November 3, 2017Date of Patent: April 18, 2023Assignees: University of Delaware, The Nemours FoundationInventors: Robert Akins, Kristi L. Kiick, Karyn Robinson, Rebecca Scott
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Publication number: 20200061244Abstract: Skeletonized blood vessels for use as vascular grafts are protected from biomechanical injury and/or certain cellular and extracellular changes by application of a biocompatible hydrogel to the vessel exterior. The hydrogel may be applied to the vessel graft before or after harvesting from a donor patient.Type: ApplicationFiled: November 3, 2017Publication date: February 27, 2020Applicants: University of Delaware, The Nemours FoundationInventors: Robert AKINS, Kristi L. Kiick, Karyn ROBINSON, Rebecca SCOTT
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Patent number: 10172938Abstract: A responsive hydrogel-based material may be used as a carrier system for the in situ delivery of various cargo substances, including bioactive moieties. The hydrogel structure, which includes photodegradable and thioether moieties in its three dimensional network, enables finely tuned local release of cargo substances as a function of the in vivo tissue environment (e.g., enzyme concentration or reducing environment) and externally applied stimuli (e.g., light) by selective spatiotemporal hydrogel degradation.Type: GrantFiled: April 28, 2015Date of Patent: January 8, 2019Assignees: University of Delaware, The Regents of the University of CaliforniaInventors: Kristi L. Kiick, April M. Kloxin, Prathamesh M. Kharkar, Raja Sivamani, Emanual Maverakis
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Publication number: 20170258907Abstract: A responsive hydrogel-based material may be used as a carrier system for the in situ delivery of various cargo substances, including bioactive moieties. The hydrogel structure, which includes photodegradable and thioether moieties in its three dimensional network, enables finely tuned local release of cargo substances as a function of the in vivo tissue environment (e.g., enzyme concentration or reducing environment) and externally applied stimuli (e.g., light) by selective spatiotemporal hydrogel degradation.Type: ApplicationFiled: April 28, 2015Publication date: September 14, 2017Applicant: University of DelawareInventors: Kristi L. KIICK, April M. KLOXIN, Prathamesh M. KHARKAR, Raja SIVAMANI, Emanual MAVERAKIS
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Patent number: 8415325Abstract: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin.Type: GrantFiled: June 14, 2010Date of Patent: April 9, 2013Assignee: University of DelawareInventors: Kristi L. Kiick, Nori Yamaguchi
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Patent number: 8338390Abstract: A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin.Type: GrantFiled: April 27, 2010Date of Patent: December 25, 2012Assignee: University of DelawareInventors: Kristi L. Kiick, Nori Yamaguchi, John Rabolt, Cheryl Casper
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Publication number: 20110033543Abstract: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin. The hydrogel may contain covalent and non-covalent crosslinks.Type: ApplicationFiled: June 14, 2010Publication date: February 10, 2011Inventors: Kristi L. Kiick, Nori Yamaguchi
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Publication number: 20100317110Abstract: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin.Type: ApplicationFiled: June 14, 2010Publication date: December 16, 2010Inventors: Kristi L. Kiick, Nori Yamaguchi
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Publication number: 20100297238Abstract: A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin.Type: ApplicationFiled: April 27, 2010Publication date: November 25, 2010Inventors: Kristi L. Kiick, Nori Yamaguchi, John Rabolt, Cheryl Casper
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Patent number: 7737131Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.Type: GrantFiled: March 31, 2006Date of Patent: June 15, 2010Assignee: University of DelawareInventors: Kristi L. Kiick, Nori Yamaguchi
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Patent number: 7732427Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.Type: GrantFiled: March 31, 2006Date of Patent: June 8, 2010Assignee: University of DelawareInventors: Kristi L. Kiick, Nori Yamaguchi, John Rabolt, Cheryl Casper
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Publication number: 20100112057Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.Type: ApplicationFiled: March 31, 2006Publication date: May 6, 2010Inventors: Kristi L. Kiick, Nori Yamaguchi
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Patent number: 5618622Abstract: A surface-modified fibrous material which includes hydrocarbon polymer fibers having cationic or anionic groups on the surfaces thereof and coated with a polyelectrolyte having a net charge opposite to that of the cationic or anionic groups on the surfaces of the fibers. The hydrocarbon polymer may be, by way of illustration, a polyolefin, such as polyethylene or polypropylene. The cationic or anionic groups may be carboxylic acid, sulfonic acid groups, or quaternary ammonium groups. Examples of polyelectrolytes include chitosan, poly(methacryloxyethyltrimethylammonium bromide), poly(acrylic acid), and poly(styrene sulfonate). Also disclosed is a method of making the surface-modified fibrous material. The surface-modified fibrous material may be used as a filtration medium for liquids.Type: GrantFiled: June 30, 1995Date of Patent: April 8, 1997Assignee: Kimberly-Clark CorporationInventors: Gunilla E. Gillberg-Laforce, Leonid A. Turkevich, Kristi L. Kiick-Fischer
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Patent number: 5538629Abstract: Disclosed is a process for disinfecting water which provides a visual indication after the disinfection is complete. First, the water to be disinfected is generally simultaneously intermixed with at least three items. The items are: (1) a disinfectant which is adapted to render harmless substantially all pathogens present in the water upon the disinfectant being intermixed with the water for a time period T.sub.k ; (2) a colorant; and (3) a material which can remove substantially all of the disinfectant and colorant from the water over a time period t.sub.r, where T.sub.r is greater than T.sub.k. Secondly, the water, disinfectant, colorant and the removing material are allowed to remain intermixed for a time period of T.sub.r or greater. At the end of the time period T.sub.r, substantially all pathogens in the water will be rendered harmless, substantially all of the disinfectant will be removed from the water and substantially all of the colorant will be removed from the water.Type: GrantFiled: December 15, 1994Date of Patent: July 23, 1996Assignee: Kimberly-Clark CorporationInventors: Carol A. Blaney, Kristi L. Kiick-Fischer, Rosann M. Kaylor
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Patent number: 5494744Abstract: Disclosed is a method of coating a permeable sheet with amphiphilic proteins, the method including the steps of: 1) providing a permeable sheet having a plurality of individual exposed surfaces, at least a portion of which having relatively low surface energies; 2) providing an aqueous solution containing amphiphilic proteins, the solution having a relatively high surface tension; and 3) contacting the solution containing amphiphilic proteins under shear stress conditions with the matrix of fibrous material so that at least a portion of the amphiphilic proteins are adsorbed onto at least some individual exposed surfaces.Type: GrantFiled: October 12, 1994Date of Patent: February 27, 1996Assignee: Kimberly-Clark CorporationInventors: Dennis S. Everhart, Kristi L. Kiick-Fischer