Patents by Inventor Kristin ENGELSTAD

Kristin ENGELSTAD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION
    Publication number: 20210069292
    Abstract: The present invention relates to recombinant Glut1 adeno-associated viral vector (AAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Inventors: Darryl DE VIVO, Umrao MONANI, Guangping GAO, Kristin ENGELSTAD
  • RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION
    Publication number: 20180042991
    Abstract: The present invention relates to recombinant Glut1 adeno-associated viral vector (rAAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals. In certain embodiments, the rAAV further comprises a chicken ?-actin promoter wherein the rAAV is capable of crossing the blood-brain barrier (BBB). In certain embodiments, the present invention relates to a composition comprising any of the recombinant AAV's described herein. In certain embodiments, the present invention relates to a kit comprising a container housing comprising the composition described herein. In certain embodiments, the present invention relates to methods of restoring Glut1 transport in the BBB of a subject, comprising administering to the subject an effective amount of any of the recombinant AAV vectors described herein. In certain embodiments, the present invention relates to a method of treating Glut1 deficiency syndrome in a subject in need thereof.
    Type: Application
    Filed: March 10, 2016
    Publication date: February 15, 2018
    Inventors: Darryl DE VIVO, Umrao MONANI, Guangping GAO, Kristin ENGELSTAD