Patents by Inventor Kristina M. Kraml

Kristina M. Kraml has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of bacterial autoinducer and use in treating bacterial pathogenicity
    Patent number: 8535689
    Abstract: A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: September 17, 2013
    Assignee: The Trustees of Princeton University
    Inventors: Bonnie Bassler, Martin Semmelhack, Douglas A. Higgins, Megan Eileen Bolitho, Kristina M. Kraml, Wai-Leung Ng
  • IDENTIFICATION OF BACTERIAL AUTOINDUCER AND USE IN TREATING BACTERIAL PATHOGENICITY
    Publication number: 20100273890
    Abstract: A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
    Type: Application
    Filed: October 1, 2008
    Publication date: October 28, 2010
    Inventors: Bonnie L. Bassler, Martin Semmelhack, Douglas A. Higgins, Megan A. Pomianek, Kristina M. Kraml, Wai-Leung Ng