Abstract: Methods and systems for managing inventory at a retail facility include an image capture device having a field of view that includes a product display shelf of the retail facility, an electronic database that stores a planogram of product display shelves at the retail facility and a computing device. The computing device obtains an image of a product display shelf, detects the individual packages of each of the different products captured in the image, defines different product display areas for the different products on the product display shelf captured in the image, and generates virtual boundary lines that surround each of the defined product display areas. The computing device also determines an identity of a product contained located in each defined product display area, and associates the virtual boundary lines surrounding each defined product display area with an identifier unique to the product contained in the defined product display area.

Abstract: Methods and systems for managing inventory at a retail facility include an image capture device having a field of view that includes a product display shelf of the retail facility, an electronic database that stores defined product display areas and assigned unique identifiers of the products on the product display shelves, and a computing device. The computing device obtains an image of a product display shelf, detects the individual packages of the different products captured in the image, identifies the products associated with the packages detected in the image by utilizing reference information stored in the database, determines whether one or more of the products on the product display shelf is associated with an out of stock event, and transmits an out of stock alert to an electronic device of a worker at the retail facility, notifying the worker to replenish the depleted products on the product display shelf.

Abstract: The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition.

Abstract: The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular secretions. In various embodiments, the methods of the invention allow for high-throughput absolute detection of secretions of cells, identification of the nature of the secreted molecules, and/or the nature of the secreting cells. Further, the present invention includes a device combining microfluidics and antibody printing, wherein the device can be used to detect protein secretion signature of cells in a high-throughput manner. Further, the present invention includes compositions comprising molecules that can be used to reduce cell death and to implement cell-less therapies. Further, the present invention includes a method for training an algorithm to predict temporal profile of cellular secretion.

Abstract: The present invention relates to the devices and method comprising microelectrode arrays for the differentiation, maturation and functional analysis of electroconductive cells, including muscle cells (including, but not limited to, cardiomyocytes, skeletal muscle myocytes and smooth muscle myocytes) and neuronal cells. The microelectrode present on the arrays can be used to stimulate and record from cells cultured on the substrate. In some embodiments, the substrate has a substantially smooth surface, and in other embodiments the substrate is nanotextured, including an array of substantially parallel grooves and ridges of nanometer-micrometer widths.

Abstract: The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition.