Patents by Inventor Ku-Lung Hsu

Ku-Lung Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREPARING AND USING AZETIDINES
    Publication number: 20230121082
    Abstract: The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.
    Type: Application
    Filed: October 12, 2022
    Publication date: April 20, 2023
    Inventors: Ku-Lung Hsu, Rebecca L. McCloud
  • Compositions and methods for preparing and using azetidines
    Patent number: 11512072
    Abstract: The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: November 29, 2022
    Assignee: University of Virginia Patent Foundation
    Inventors: Ku-Lung Hsu, Rebecca L. McCloud
  • CYSTEINE BINDING COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20220251085
    Abstract: Purine-derived covalent probes (e.g., halo or di-halo-substituted purine based covalent probes) and related ligands are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive cysteine residues, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues (e.g., reactive cysteine residues) via the formation of protein adducts comprising the ligands Modified proteins prepared from the probes and ligands are also described.
    Type: Application
    Filed: July 21, 2020
    Publication date: August 11, 2022
    Applicant: University of Virginia Patent Foundation
    Inventors: Ku-Lung Hsu, Adam Libby, Andy Heindel, Jeffrey W. Brulet, Boobalan Pachaiyappan
  • SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF
    Publication number: 20220214355
    Abstract: Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 7, 2022
    Applicant: University of Virginia Patent Foundation
    Inventors: Ku-Lung Hsu, Heung Sik Hahm, Emmanuel K. Toroitich, Jeffrey W. Brulet, Adam L. Borne, Adam Herman Libby, Kun Yuan
  • COMPOSITIONS AND METHODS FOR PREPARING AND USING AZETIDINES
    Publication number: 20210101884
    Abstract: The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.
    Type: Application
    Filed: April 19, 2019
    Publication date: April 8, 2021
    Inventors: Ku-Lung Hsu, Rebecca L. McCloud
  • COMPOSITIONS AND USES THEREOF
    Publication number: 20200231551
    Abstract: The disclosure is directed to compounds of the formula (IA), (I)-(V) and others disclosed herein and uses of such compounds.
    Type: Application
    Filed: June 26, 2018
    Publication date: July 23, 2020
    Inventors: Ku-Lung Hsu, Caroline Elise Franks, Heung Sik Hahm, Jeffrey W. Brulet, Tao Huang
  • N1- and N2-carbamoyl-1,2,3-triazole serine hydrolase inhibitors and methods
    Patent number: 9108930
    Abstract: The present invention provides inhibitors of a wide variety of serine hydrolase enzymes. The inhibitors of the present invention are N1- and N2-carbamoyl-1,2,3-triazole compounds such as those of Formula (I): in which N1, N2, and N3 are the nitrogen atoms at positions 1, 2, and 3, respectively, of the triazole ring, and R4, R5, R6 and R7 in Formula (I) are as described herein. Methods of inhibiting serine hydrolase enzymes and methods of preparing carbamoyl-1,2,3-triazole compounds also are described.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: August 18, 2015
    Assignee: The Scripps Research Institute
    Inventors: Benjamin Cravatt, Alexander Adibekian, Katsunori Tsuboi, Ku-Lung Hsu
  • N1- and N2-CARBAMOYL-1,2,3-TRIAZOLE SERINE HYDROLASE INHIBITORS AND METHODS
    Publication number: 20140018318
    Abstract: The present invention provides inhibitors of a wide variety of serine hydrolase enzymes. The inhibitors of the present invention are N1- and N2-carbamoyl-1,2,3-triazole compounds such as those of Formula (I): in which N1, N2, and N3 are the nitrogen atoms at positions 1, 2, and 3, respectively, of the triazole ring, and R4, R5, R6 and R7 in Formula (I) are as described herein. Methods of inhibiting serine hydrolase enzymes and methods of preparing carbamoyl-1,2,3-triazole compounds also are described.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 16, 2014
    Applicant: The Scipps Research Institute
    Inventors: Benjamin Cravatt, Alexander Adibekian, Katsunori Tsuboi, Ku-Lung Hsu