Abstract: The present invention provides binding molecules, including monoclonal antibodies, multi-specific antibodies, and antibody fragments, that specifically bind to the coronavirus, such as SARS-CoV-2, and methods of use thereof. In some aspects of the invention, the binding molecules are human antibodies, fragments, or derivatives thereof that specifically bind to SARS-CoV-2 spike protein. In some aspects of the invention, the binding molecules function to neutralize SARS-CoV-2. The present invention also relates to methods of using the binding molecules and compositions for diagnosis and treatment.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: a pharmaceutical composition for preventing, treating, or ameliorating one or more symptoms of a malignant tumor associated with EGFR mutation and/or K-RAS mutation is provided. The pharmaceutical composition includes a 4-anilinoquinazoline derivative having a formula (I) where A is iodine when m is 1 and n is zero, or A is albumin when m is an integral ranging from 1 to 7 and n is 1.

Abstract: EGFR mutation (T790M) and cancerous stemness have shown drug resistances in human non-small-cell lung cancer (NSCLC), thus development of novel drugs in overcoming drug resistances in the NSCLC therapy is highly desired. SP101 is a novel gefitinib derivative, which can bind the ATP-binding pocket of EGFR to inhibit its EGFR kinase activity. SP101 can reduce the drug resistances of EGFR mutation (T790M) and cancerous stemness in NSCLC. SP101 induced cancer cell death and apoptosis in the gefitinib-resistant EGFR mutation (T790M) H1975 cells. SP101 inhibited phosphorylated EGFR and its downstream Survivin proteins but conversely induced Caspase 3 activation for apoptosis induction. Moreover, SP101 could decrease Oct4 protein level and reduce Survivin proteins but conversely elicited active Caspase 3 in the xenograft human H1975 lung tumors in nude mice.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: An absorbent article may comprise a chassis having a front waist region, a rear waist region, a crotch region between the front waist region and the rear waist region, a pair of longitudinal edges, and a pair of side panels extending between and connecting the front waist region and the rear waist region to form a leg opening. Each side panel may comprise a stretch laminate joined by a mechanical bond. The article may bear a chassis graphic disposed on a backsheet and a side panel graphic disposed on a side panel.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: An absorbent article may comprise a chassis having a front waist region, a rear waist region, a crotch region between the front waist region and the rear waist region, a pair of longitudinal edges, and a pair of side panels extending between and connecting the front waist region and the rear waist region to form a leg opening. Each side panel may comprise a stretch laminate joined by a mechanical bond. The article may bear a chassis graphic disposed on a backsheet and a side panel graphic disposed on a side panel.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: The present invention relates to disposable absorbent articles. The disposable absorbent articles include: (a) a body contacting surface; (b) a garment contacting surface opposite the body contacting surface; and (c) an inkjet printed wetness indicator which is seen through either the body contacting surface or the garment contacting surface. The wetness indicator includes a central graphic and a background graphic, the central graphic having at least one permanent ink composition and the background graphic having at least one water soluble ink composition.

Abstract: A disposable wearable absorbent article comprises a topsheet, an absorbent core, an outer cover, a waist opening, leg openings, a first visual fullness indicating area, and a second visual fullness indicating area. The first visual fullness indicating area is configured to change to a first subsequent color when indicating the presence of a bodily exudate. The second visual fullness indicating area is configured to change to a second subsequent color when indicating the presence of a bodily exudate. The second subsequent color is visually distinguishable from the first subsequent color. At least a portion of each of the visual fullness indicating areas is visible from outside of the disposable wearable absorbent article when the article is worn by a wearer.

Abstract: A package for treating stained fabric. The package can have a backing layer having a second side and a pouch layer joined thereto to form a pouch. A fluid pervious contact substrate can be joined to a first side of the backing layer. The pouch can contain a stain treatment fluid. The package can have a first position in which first and second planar regions of the backing layer are substantially in plane with one another. The package can have a second position in which first planar region and second planar region are in a substantially angularly facing relationship. In the second position the pouch can be in fluid communication with the contact substrate. The stain treatment fluid can include a surfactant.

Abstract: A method for treating a stained fabric using a package is disclosed. The package can have a backing layer having a second side and a pouch layer joined thereto to form a pouch. A fluid pervious contact substrate can be joined to a first side of the backing layer. The pouch can contain a stain treatment fluid. The method comprises bending the backing layer, dispensing the stain treatment fluid to the fluid pervious contact substrate through a portion of the backing layer; gripping the backing layer and rubbing the stained fabric with the contact substrate.

Abstract: A disposable wearable absorbent article comprises a topsheet, an absorbent core, an outer cover, a waist opening, leg openings, a first visual fullness indicating area, and a second visual fullness indicating area. The first visual fullness indicating area is configured to change to a first subsequent color when indicating the presence of a bodily exudate. The second visual fullness indicating area is configured to change to a second subsequent color when indicating the presence of a bodily exudate. The second subsequent color is visually distinguishable from the first subsequent color. At least a portion of each of the visual fullness indicating areas is visible from outside of the disposable wearable absorbent article when the article is worn by a wearer.

Abstract: An absorbent article may comprise a chassis having a front waist region, a rear waist region, a crotch region between the front waist region and the rear waist region, a pair of longitudinal edges, and a pair of side panels extending between and connecting the front waist region and the rear waist region to form a leg opening. Each side panel may comprise a uniformly colored stretch laminate. The stretch laminate may comprise a colored elastomeric member and a first substrate joined to the elastomeric material. The side panels may be joined by a mechanical bond which may form an informational indicia.

Abstract: A device for treating a target surface, such as occurs when cleaning a window. The device has plural squeegee blades joined by a head. The head has a slot therethrough. A sheet may be longitudinally move over one or more than one of the blades to renew its surface before, during or after use. Each squeegee blade may have a dedicated sheet. The sheet(s) may travel through the slot to originate from or be stored within the head.

Abstract: Disposable absorbent articles comprising a liquid pervious topsheet, a liquid impervious backsheet that is at least partially joined to the topsheet, an absorbent core disposed at least partially between the topsheet and the backsheet, and a wetness indicator printed onto a surface of the backsheet wherein the wetness indicator comprises a graphic that further comprises at least one responsive color composition and a varnish coating disposed adjacent to the responsive color composition; wherein upon wetting, the graphic becomes visible to the unaided eye.

Abstract: A device for treating a target surface, such as occurs when cleaning a window. The device has a squeegee blade or other member to apply pressure to the target surface. A sheet movably covers the blade, to present a fresh covering to the target surface with each use. The fresh surface provides for improved removal of the liquid from, or improved treatment of the liquid on, the target surface. Additionally a sheet may comprise a prewetted substrate to apply the liquid to the target surface. One or both of the sheets may be disposed in a cartridge insertable to and removable from the device.

Abstract: A package for treating stained fabric. The package can have a backing layer having a second side and a pouch layer joined thereto to form a pouch. A fluid pervious contact substrate can be joined to a first side of the backing layer. The pouch can contain a stain treatment fluid. The package can have a first position in which first and second planar regions of the backing layer are substantially in plane with one another. The package can have a second position in which first planar region and second planar region are in a substantially angularly facing relationship. In the second position the pouch can be in fluid communication with the contact substrate. The stain treatment fluid can include a surfactant.