Patents by Inventor Kuei-Hsuan Hsiao

Kuei-Hsuan Hsiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for determining cyclic nucleotide concentration and related pathway activation
    Patent number: 10781472
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods and systems for detecting or determining cyclic nucleotide concentrations and related pathway activation in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase (e.g., cAMP- and cGMP-dependent protein kinases) and a detection system that includes a substrate capable of being phosphorylated by the cyclic nucleotide-dependent protein kinase. The activity of cyclic nucleotide related cell signaling pathways may be measured based on detecting the activity of the cyclic nucleotide-dependent protein kinase.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: September 22, 2020
    Assignee: PROMEGA CORPORATION
    Inventors: Said A. Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene
  • METHODS FOR CYCLIC NUCLEOTIDE DETERMINATION
    Publication number: 20180340210
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase and a detection system which includes a substrate for the cyclic nucleotide-dependent protein kinase. The activities in cyclic nucleotide related pathways may be measured using the detection system.
    Type: Application
    Filed: June 7, 2018
    Publication date: November 29, 2018
    Inventors: Said A. Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene
  • Methods for cyclic nucleotide determination
    Patent number: 10000792
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase and a detection system which includes a substrate for the cyclic nucleotide-dependent protein kinase. The activities in cyclic nucleotide related pathways may be measured using the detection system.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: June 19, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Said A. Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene
  • LUMINESCENT DETECTION OF INORGANIC PHOSPHATE AND COUPLED REACTIONS
    Publication number: 20140273036
    Abstract: Luminescent detection of inorganic phosphate is carried out in an assay through the intermediary enzymatic production of ADP. ADP is converted to ATP which is used in a luminescent reaction. The assay can be used to monitor coupled enzyme reactions which use or generate inorganic phosphate and the modulation of such reactions.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: PROMEGA CORPORATION
    Inventors: Subhanjan Mondal, Kuei-Hsuan Hsiao, Said Goueli
  • METHODS FOR CYCLIC NUCLEOTIDE DETERMINATION
    Publication number: 20110129821
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase and a detection system which includes a substrate for the cyclic nucleotide-dependent protein kinase. The activities in cyclic nucleotide related pathways may be measured using the detection system.
    Type: Application
    Filed: February 22, 2010
    Publication date: June 2, 2011
    Applicant: PROMEGA CORPORATION
    Inventors: Said A. Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene
  • Methods for cyclic nucleotide determination
    Publication number: 20070172896
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples.
    Type: Application
    Filed: December 6, 2006
    Publication date: July 26, 2007
    Applicant: Promega Corporation
    Inventors: Said Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene