Abstract: The present disclosure relates to medicine delivery devices, as well as methods of delivering an aerosol medicine to a subject in need thereof. A benefit to the medicine delivery devices and methods herein can be the efficient delivery of an aerosol medicine to a subject in need thereof, thus helping to improve treatment outcomes, as well as avoiding wastage of expensive medicines. Additional benefits to the medicine delivery devices disclosed herein can be low cost, lightweight, compact, versatile, and simple to use devices useful for a wide range of patients and healthcare settings. Another benefit of the medicine delivery devices can be safer to use devices that can lower the risk of infection for patients and healthcare providers.