Abstract: This invention provides an antipruritic comprising an ipoate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Abstract: This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.

Abstract: A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.

Abstract: A remedy for drug dependence in which the active ingredient is an opioid &kgr; receptor agonist in which the typical compound is represented by the following formula.

Abstract: This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Abstract: A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.

Abstract: A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.

Abstract: This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Abstract: The present invention provides a novel process for producing 4a-aryldecahydroisoquinoline compounds. The process is especially useful for preparing 4a-trans-6-oxo-aryldecahydroisoquinoline compounds.

Abstract: The present invention provides a working fluid composition for a refrigerating machine obtained by mixing an ammonia refrigerant with a lubricating oil which is extremely excellent in solubility with the ammonia refrigerant, and a method for lubricating a refrigerating machine suitable for the use of the working fluid composition.The working fluid composition comprises a mixture of ammonia and one or more kinds of polyether compounds represented by the formula (I); the refrigerating machine is characterized by constituting a refrigerating cycle or a heat pump cycle through which the working fluid composition is circulated; and the method for lubricating a refrigerating compressor is characterized by lubricating the ammonia refrigerant compressor with the lubricating oil comprising one or more kinds of ether compounds represented by the formula (I)R.sub.1 --?--O--(PO).sub.m --(EO).sub.n --R.sub.2 !.sub.x (I)wherein R.sub.1 is a hydrocarbon group having 1 to 6 carbon atoms, R.sub.

Abstract: The present invention provides a working fluid composition for a refrigerating machine obtained by mixing an ammonia refrigerant with a lubricating oil which is extremely excellent in solubility with the ammonia refrigerant. The working fluid composition comprises a mixture of ammonia and one or more kinds of polyether compounds; the refrigerating machine is characterized by constituting a refrigerating cycle or a heat pump cycle through which the working fluid composition is circulated.

Abstract: A latent heat storage apparatus is provided and a latent heat storage solution therefor stores and retrieves a cool heat substantially in or from a latent heat thereof necessary for air conditioning, cooling, refrigerating, and so forth. The latent heat storage apparatus has an aqueous solution of a plurality of inorganic salts as a latent heat storage solution in a heat storage tank, formed to retrieve a cold heat from a stored latent heat, the latent heat storage apparatus. The latent heat storage solution is formed of (N-1) kinds of inorganic salts in at least an N-component aqueous solution where N.gtoreq.3. The latent heat storage solution stores the cold heat as the latent heat thereof. The cold heat is retrievable from the stored latent heat at a desired temperature almost invariably within a range higher than the N-component eutectic point and lower than any one of binary eutectic points of salts with water.