Patents by Inventor Kunihiko Tatsumi

Kunihiko Tatsumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Condensed pyrazole derivatives, and androgen inhibitor
    Patent number: 5516777
    Abstract: This invention provides a condensed pyrazole derivative of the Formula (1): ##STR1## (where A denotes CH or N, R.sup.0 and R.sup.3 denote same or different, a hydrogen atom or a lower alkyl group, R.sup.1 and R.sup.2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R.sup.2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: May 14, 1996
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kiyokawa, Satoshi Yamada, Keisuke Miyajima, Koji Edamatsu, Kunihiko Tatsumi, Takeshi Yamauchi, Kazumasa Kishi, Kunihiko Kiyono
  • Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
    Patent number: 5420128
    Abstract: The invention discloses a pyrimidien derivative expressed in Formula [I]: ##STR1## where R.sup.1 denotes a hydrogen atom or hydroxyl group, R.sup.2 denotes a hydrogen atom, lower alkoxycarbonyl group, lower alkoxy group, halogen atom, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, lower alkoxycarbonyl lower alkyl group, carboxyl group, carboxy lower alkyl group, group: --CONHR.sup.6 (R.sup.
    Type: Grant
    Filed: June 9, 1992
    Date of Patent: May 30, 1995
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kiyokawa, Satoshi Yamada, Keisuke Miyajima, Kinji Hashimoto, Masatoshi Inai, Makoto Inoue, Kunihiko Tatsumi, Takeshi Yamauchi, Kazunobu Kurisu, Yoshifumi Chone
  • Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor
    Patent number: 5409928
    Abstract: This invention provides a condensed pyrazole derivative of the Formula (1): ##STR1## (where A denotes CH or N, R.sup.0 and R.sup.3 denote same or different, a hydrogen atom or a lower alkyl group, R.sup.1 and R.sup.2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R.sup.2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: April 25, 1995
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kiyokawa, Satoshi Yamada, Keisuke Miyajima, Koji Edamatsu, Kunihiko Tatsumi, Takeshi Yamauchi, Kazumasa Kishi, Kunihiko Kiyono