Patents by Inventor Kunizo Mori

Kunizo Mori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification process of a human growth hormone
    Patent number: 5760187
    Abstract: A human growth hormone can be purified by allowing a solution containing the human growth hormone to contact with a blue pigment-bonded carrier in order to selectively adsorb the human growth hormone, then eluting the human growth hormone with an eluant of high ionic strength or an eluant containing a protein denaturing agent. This method readily enables the mass production of a highly purified human growth hormone.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: June 2, 1998
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Yuji Nagatomi, Kunizo Mori, Hideki Kobayashi, Nobumi Kusuhara
  • Method for purifying a crude tissue plasminogen activator preparation
    Patent number: 5158882
    Abstract: Separation of tPA and undesired proteins is securely and effectivity accomplished by using a cation-exchanger in the two step procedure for selective elution of undesired proteins from the cation-exchanger on which tPA and undesired proteins are adsorbed: undesired proteins having the pI equivalent to or lower than that of tPA was eluted out in the first step and then undesired proteins having the pI equivalent to or higher than were eluted in the second step.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: October 27, 1992
    Assignee: Mitsui Toatsu Chemical Incorporated
    Inventors: Mitsuyoshi Morii, Nobuhiro Kawashima, Kunizo Mori, Masaharu Ohoka
  • Process for separating single-chain TPA and double-chain from each other
    Patent number: 4978620
    Abstract: The distinction of tissue plasminogen activator, especially, the separation of its single-chain species and double-chain species is effected by using the Erythrina trypsin inhibitor which occurs in seeds of a plant of the Erythrina species.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: December 18, 1990
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Mitsuyoshi Morii, Masaharu Ohoka, Toshihiko Suzuki, Katsuyuki Suzuki, Nobuhiro Kawashima, Noriko Morii, Kunizo Mori
  • Methods for purification of single-chain and double-chain tissue plasminogen activator
    Patent number: 4898825
    Abstract: A mixture containing a single-chain tissue plasminogen activator (tPA) and/or double-chain tPA is brought into close contact with a column carrying an immobilized Erythrina trypsin inhibitor as an affinity agent. Adsorbed protiens are eluted with eluents having different pHs with or without arginine or benzamidine, so that single-chain tPA is obtained in the eluent with a pH at least 4.5 and double-chain tPA is obtained in the eluent with a pH lower than 4.5.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: February 6, 1990
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Mitsuyoshi Morii, Masaharu Ohoka, Toshihiko Suzuki, Katsuyuki Suzuki, Nobuhiro Kawashima, Noriko Morii, Kunizo Mori