Abstract: Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

Abstract: The present application relates to a compound as a TGF-? R1 inhibitor and application thereof. Specifically, provided are a compound of formula I, or an isomer, pharmaceutically acceptable salt, solvent, crystal, or prodrug thereof, preparation methods therefor, and pharmaceutical compositions comprising these compounds, and applications of these compounds or compositions in treating and/or preventing TGF-? R1-related diseases, such as cancer, tissue proliferation diseases, fibrosis, and inflammatory diseases. The compound represents a significant inhibitory activity for TGF-? R1 kinase, and is promising as a treatment agent for TGF-? R1-related diseases.