Abstract: A method and system of providing therapy to a patient's uterus. The method include the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, inserting a vapor delivery tool through an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool, the access tool being adapted to be inserted through a human cervical canal to place an opening of the access tool lumen within a uterus when the access tool is inserted through the cervical canal; and a vapor delivery mechanism, the vapor delivery mechanism having a vapor delivery tool and a vapor source, the vapor delivery tool being adapted to be inserted through the access tool to deliver condensable vapor from the vapor source to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: A method and system of providing therapy to a patient's uterus. In some embodiments the method includes the steps of: inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a human cervical canal to place an opening of an access tool lumen within a uterus when the access tool is inserted through the cervical canal; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: Devices, systems and methods are provided for electrical stimulation of a body organ, particularly within the gastrointestinal tract. In preferred embodiments, the stomach is the organ within the gastrointestinal tract which is targeted for such stimulation. A guide wire or other delivery device is positioned within the body so as to transect the stomach wall. Devices and systems are then advanced over the guide wire for attachment to the stomach wall. The guide wire may be placed by endoscopic, open, laparoscopic or a modified percutaneous approach. In a modified percutaneous approach, the stomach is accessed without the use of general anesthesia by advancing a needle through the abdomen, transecting the stomach wall with the needle and advancing the guide wire through the needle.

Abstract: A method and system of providing therapy to a patient's uterus. The method include the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, inserting a vapor delivery tool through an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool, the access tool being adapted to be inserted through a human cervical canal to place an opening of the access tool lumen within a uterus when the access tool is inserted through the cervical canal; and a vapor delivery mechanism, the vapor delivery mechanism having a vapor delivery tool and a vapor source, the vapor delivery tool being adapted to be inserted through the access tool to deliver condensable vapor from the vapor source to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: A method and system of providing therapy to a patient's uterus. The method includes the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, creating a seal between an exterior surface of the access tool and an interior cervical os; providing an indication to a user that the seal has been created; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus.

Abstract: A method and system of providing therapy to a patient's uterus. In some embodiments the method includes the steps of: inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a human cervical canal to place an opening of an access tool lumen within a uterus when the access tool is inserted through the cervical canal; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: A method and system of providing therapy to a patient's uterus. The method includes the steps of inserting an access tool through a cervix and a cervical canal into the uterus; actively cooling the cervical canal; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; an active cooling mechanism adapted to cool the cervical canal, the active cooling mechanism having a coolant source; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: Gastric stimulation devices, systems and methods are provided, particularly for stimulating a gastric organ having an internal cavity. Such devices and systems are typically implanted outside of the gastric organ while the environment of the internal cavity is probed and monitored by one or more sensors. The sensor information may be used to affect the stimulation signals provided to the gastric organ by the devices and systems. Such feedback integration assists in providing treatments and stimulation programs that are tailored to the needs of the individual patient.

Abstract: Devices, systems and methods are provided for electrical stimulation of a body organ, particularly within the gastrointestinal tract. In preferred embodiments, the stomach is the organ within the gastrointestinal tract which is targeted for such stimulation. A guide wire or other delivery device is positioned within the body so as to transect the stomach wall. Devices and systems are then advanced over the guide wire for attachment to the stomach wall. The guide wire may be placed by endoscopic, open, laparoscopic or a modified percutaneous approach. In a modified percutaneous approach, the stomach is accessed without the use of general anesthesia by advancing a needle through the abdomen, transecting the stomach wall with the needle and advancing the guide wire through the needle.

Abstract: A catheter system and corresponding methods are provided for accessing a blood vessel true lumen from a sub-intimal plane of the vessel. The catheter system includes visualization elements for determining the orientation of the true lumen with respect to the sub-intimal plane at an identified entry site from a position in the sub-intimal plane. The entry site is distal to a chronic total occlusion (CTO). The catheter system also includes a system for physically securing tissue of the sub-intimal plane at the entry site to the catheter system. The attaching system reduces or eliminates catheter float within the sub-intimal space. The catheter system further includes re-entry devices to establish and maintain a path from the sub-intimal plane back into the vessel true lumen.

Abstract: A method and apparatus for micro-dissection of vascular occlusions are provided wherein two or more tissue expansion members are coupled with a base section and an actuation assembly so that they rotate radially outward from the central axis of the base. The actuating assembly occupies a channel within the base such that it is free to move in a longitudinal direction. As an external force is applied to the actuation assembly, the actuation assembly engages the tissue expansion members causing them to move in a radial outward direction with respect to the base section. The resulting motion causes the tissue expansion members to contact the tissue walls and/or the occlusion. The tissue expansion members can stretch the tissue walls causing the occlusion to tear, fracture or be disrupted or displaced.

Abstract: An instrument shaft for use in small openings where enhanced longitudinal dimensional stability and compressive loading characteristics are desirable. Various embodiments may be shafts of catheters used to treat peripheral vasculatures or coronary vasculatures. Embodiments of the catheter shaft provide enhanced longitudinal dimensional stability and compressive loading characteristics, while maintaining flexibility under loading conditions. In one embodiment, a catheter shaft includes an outer catheter shaft with a lumen therethrough, and an annular compression spring inside the outer catheter shaft. Also included is an actuation member inside the annular compression spring, wherein the actuation member actuates a working element at a distal end of the catheter.

Abstract: An apparatus for treating occlusions. In one embodiment, the apparatus comprises an outer catheter shaft with at least one axial lumen therethrough, wherein the outer catheter shaft comprises a distal end having an outer diameter, and an inner catheter shaft having an average diameter slidably disposed in the at least one axial lumen of the outer catheter shaft. The inner catheter shaft comprises at least one axial lumen therethrough, and an a traumatic, tapered protuberance comprising a distal end and a proximal end, wherein a diameter of the a traumatic, tapered protuberance tapers upward from the average diameter at the distal end to a greatest diameter at the proximal end. The embodiment further comprises a guidewire slidably disposed in the at least one axial lumen of the inner catheter shaft, wherein the guidewire is advanced through the body lumen into the occlusion.

Abstract: A catheter system and corresponding methods are provided for accessing a blood vessel true lumen from a sub-intimal plane of the vessel. The catheter system includes visualization elements for determining the orientation of the true lumen with respect to the sub-intimal plane at an identified entry site from a position in the sub-intimal plane. The entry site is distal to a chronic total occlusion (CTO). The catheter system also includes a system for physically securing tissue of the sub-intimal plane at the entry site to the catheter system. The attaching system reduces or eliminates catheter float within the sub-intimal space. The catheter system further includes re-entry devices to establish and maintain a path from the sub-intimal plane back into the vessel true lumen.

Abstract: An apparatus for treating occlusions. In one embodiment, the apparatus comprises an outer catheter shaft with at least one axial lumen therethrough, wherein the outer catheter shaft comprises a distal end having an outer diameter, and an inner catheter shaft having an average diameter slidably disposed in the at least one axial lumen of the outer catheter shaft. The inner catheter shaft comprises at least one axial lumen therethrough, and an atraumatic, tapered protuberance comprising a distal end and a proximal end, wherein a diameter of the atraumatic, tapered protuberance tapers upward from the average diameter at the distal end to a greatest diameter at the proximal end. The embodiment further comprises a guidewire slidably disposed in the at least one axial lumen of the inner catheter shaft, wherein the guidewire is advanced through the body lumen into the occlusion.

Abstract: Embodiments of a catheter for intravascular procedures are described. The embodiments described include a catheter with various elements arranged about a central axis. The elements include an inner shaft, an outer shaft, and an actuation mechanism. In one embodiment, the inner shaft forms the actuation mechanism, and includes a flexible hypotube. The flexible hypotube further forms a lumen that can accommodate, for example, a guidewire. The actuation mechanism actuates, or deploys, a working element at the distal end of the catheter. In one embodiment, the working element includes a tissue spreading member for disrupting an occlusion. In one embodiment, the catheter includes an imaging element that helps the operator of the catheter determine where the working element is located with respect to tissue.

Abstract: Apparatus and method is disclosed relating to an infusion catheter for treating a subject region with a treatment solution. A guide catheter allows the infusion catheter to be inserted into the subject and placed near a treatment region within the vascular system. A solution source is used to selectively inflate an infusion device. A passageway in the catheter body extends to an infusion device which has inner and outer chambers. Holes in a wall of the inner chamber route solution into the outer chamber and holes in the wall of the outer chamber route the solution into a subject vasculature. Solution pressure in the inner chamber is greater then the solution pressure in the outer chamber due to the relatively greater area of the holes in the outer chamber wall.