Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: A request to play a media content item is received. It is determined whether the play request is ambiguous. Responsive to determining that the play request is ambiguous, then it is determined whether to play a suspended media content item or an alternate media content item. The determination can be made based on a length of time that the suspended media content item has been suspended, a media content item type, or a state, among other factors. Responsive to the determination, playback of the suspended or alternate media content item is initiated.

Abstract: A system for generating and authenticating remote sensing imagery includes a remote sensing platform. The remote sensing platform includes an imaging sensor and a hardware logic device that is directly coupled to the imaging sensor. The hardware logic device receives image data from the imaging sensor and generates a cryptographic signature based upon the image data. The hardware logic device outputs a signed image that includes the image data and the cryptographic signature. A computing device operated by a downstream user receives the signed image and can determine whether the image data has been modified from its original content based upon the cryptographic signature.

Abstract: The invention relates to methods and procedures in the fabrication and placement of a Form in Place Permanent Dry Dock System (PDDS), that is created without moving or disturbing the target ship during fabrication or placement. The PDDS provides an “in the water illusion” of the ship on permanent display while having the ship totally out of the water resting on a conformal concrete pedestal. To provide the illusion a two-layer concrete base is created using underwater setting concrete and high strength non-ferrous reinforcing bars “rebar”. The first concrete layer is the base pedestal the second layer is flexible concrete that acts as a conformal and form fitting cushion that insures even distribution of the ships weight and provides earthquake resilience.

Abstract: A control apparatus providing a Dynamic Artificial Intelligence system, which employs data sets and software functions representing a plurality interactive software engine's, including Inference, Neural Net, State, and Proportional-Integral-Derivative (PID) Engines. These engines are implemented as a set of scheduled realtime monitors and callable functions with associated processes preformed within a system. Monitors dynamically estimates and determine the optimal control policy for the system and its sub-systems. Monitors utilize an iterative process of sub-steps “function calls’, until a convergence states exist. Functions and subfunctions dynamically estimate the desired value for operation at a respective state of the environment over a series of predicted environmental states; using a complex return of data sets to determine bounds to improve the estimated currently desired value; and producing updated estimates of optimal control policies.

Abstract: An apparatus for the real time evaluation of in vivo tissue ablation is provided. The apparatus comprises a Near Infrared illumination source that delivers light to one side of a windowed flow-thru cuvette and exit to a Fourier-Transform Infrared [FTIR] spectrometer opposite the light source. The light traversal is via fiberoptic cables. While surgical smoke traverses the cuvette, the smoke is subjected to continuous FTIR sampling and those samples are compared in real time to a database of known cancer, necrotic or diseased tissue spectrums, utilizing Artificial Intelligence [AI] software. The apparatus in real-time indicates to the surgeon weather the ablation smoke contains cancerous or normal tissue via LED's, sounds, or tactile indicators.

Abstract: A device for transferring images from an image donating member to an image receiving medium comprises a substrate, at least two electrodes disposed on the substrate, and at least one layer of coating disposed on the substrate having an outer surface for forming a nip region with the image donating member. The at least two electrodes are controllable to produce an electric field and control a position thereof at the nip region to allow transfer of an image from the image donating member to the image receiving medium in an image transfer operation.

Abstract: A toner adder roll according to one example embodiment includes an electrically conductive shaft defining an axis of rotation of the toner adder roll. A foam member is cylindrically disposed about the shaft and forms an outer circumferential surface of the toner adder roll. The foam member is composed of a polymeric open-cell foam material. An abrasive agent is dispersed on the outer circumferential surface of the toner adder roll.

Abstract: A device for transferring images from an image donating member to an image receiving medium comprises a substrate, at least two electrodes disposed on the substrate, and at least one layer of coating disposed on the substrate having an outer surface for forming a nip region with the image donating member. The at least two electrodes are controllable to produce an electric field and control a position thereof at the nip region to allow transfer of an image from the image donating member to the image receiving medium in an image transfer operation.

Abstract: A device for transferring images from an image donating member to an image receiving medium comprises a substrate, at least two electrodes disposed on the substrate, and at least one layer of coating disposed on the substrate having an outer surface for forming a nip region with the image donating member. The at least two electrodes are controllable to produce an electric field and control a position thereof at the nip region to allow transfer of an image from the image donating member to the image receiving medium in an image transfer operation.

Abstract: An imaging apparatus having a toner transfer station, including a donating member for donating toner forming an image; and a transfer roll which serves to form a transfer nip in which toner is transferred from the donating member to a media sheet disposed in the transfer nip between the donating member and the transfer roll, wherein a product of a resistivity of the transfer nip and a dielectric constant thereof is greater than or equal to a product of a resistivity of the media sheet and a dielectric constant thereof.

Abstract: Apparatus and methods are provided for holding an archery bow in a ready, near shooting position. A harness is worn around a hunter's chest. A sling also attaches to the hunter for holding a lower cam/pulley or lower limb of a compound archery bow. A bow string holder is carried by the harness. The bow string holder attaches to a string portion of the compound archery bow and allows the archery bow to hang therefrom to maintain tension on the bow string holder. The tension prevents the bow string holder from releasing the string until the tension is released upon the hunter's lifting of the archery bow from the sling for shooting an arrow.

Abstract: Apparatus and methods are provided for holding an archery bow in a ready, near shooting position. A harness is worn around a hunter's chest. A sling also attaches to the hunter for holding a lower cam/pulley or lower limb of a compound archery bow. A bow string holder is carried by the harness. The bow string holder attaches to a string portion of the compound archery bow and allows the archery bow to hang therefrom to maintain tension on the bow string holder. The tension prevents the bow string holder from releasing the string until the tension is released upon the hunter's lifting of the archery bow from the sling for shooting an arrow.

Abstract: An imaging apparatus having a toner transfer station, including a donating member for donating toner forming an image; and a transfer roll which serves to form a transfer nip in which toner is transferred from the donating member to a media sheet disposed in the transfer nip between the donating member and the transfer roll, wherein a product of a resistivity of the transfer nip and a dielectric constant thereof is greater than or equal to a product of a resistivity of the media sheet and a dielectric constant thereof.

Abstract: A spacer and a method for its use in an outer wall of a building between the outer vertical surface of its underlying structure and the inner surfaces of each of the portions of overlapped lengths of siding through which the lengths of siding are nailed to the underlying structure to provide a ventilation space between the rear surfaces of the lengths of siding and the outer surface of the underlying structure. The spacers each have a planer rear surface adapted to be positioned against the outer surface of the underlying structure, and a planer front surface portion that can be disposed at a small acute angle (e.g., in the range of about 2 to 3 degrees) with respect to the rear surface at which angle it is desired to have the rear surfaces of the lengths of siding disposed with respect to the outer surface of the underlying structure.

Abstract: A spacer and a method for its use in an outer wall of a building between the outer vertical surface of its underlying structure and the inner surfaces of each of the portions of overlapped lengths of siding through which the lengths of siding are nailed to the underlying structure to provide a ventilation space between the rear surfaces of the lengths of siding and the outer surface of the underlying structure. The spacers each have a planer rear surface adapted to be positioned against the outer surface of the underlying structure, and a planer front surface portion that can be disposed at a small acute angle with respect to the rear surface at which angle it is desired to have the rear surfaces of the lengths of siding disposed with respect to the outer surface of the underlying structure. Ventilation channels can be provided at both the lower and upper ends of the ventilation space to facilitate movement of air to the atmosphere from such a ventilation space.

Abstract: A Needleless injector patch for the intra-muscular, subcutaneous, or intra-dermal delivery of a fluid medicament to a patient includes a plurality of cylindrical members “Micro-Injectors” which have a closed end and an sealed orifice end, the Micro-Injectors contain a pyrotechnic gas generating charge, a diaphragm or a piston assembly and a quantity of medication. An onboard microprocessor programmatically selects the time to initiate a Micro-Injector unit by applying current to the pyrotechnic charge generating a volume of gas which pushes a diaphragm or piston pressurizing the medication to the point that a rupture element bursts allowing the medication to be expelled as a fine stream at high pressure that pierces the epidermis to a controlled depth delivering the medication as an injection.

Abstract: A intelligent sports and safety helmet designed for bicyclists, skateboarders, snowboarders, skiers, other sports enthusiast as well as industrial, military and security services that utilizes a helmets or head protection while performing an activity or duty. The helmet consists of a sports or safety helmet with a Microprocessor, a set of sensors and a software program residing within the microprocessor. In operation electronic sensors automatically detect if the user is wearing helmet and if environmental conditions warrant self-illumination. The microprocessor manages the state of the illuminating elements.

Abstract: A steering lock mechanism having an actuator communicating with a lock bolt is provided allowing for more space in the vicinity where a steering wheel is supported by an upper steering shaft. Additionally, a bolt engaging device is supported adjacent a lower end of the upper steering shaft in a position to engage a lock bolt such that any torque forces transmitted through the bolt engaging device will not cause damage to either the device or other components of the steering column. The actuator is rotated about an axis from a first position to a second position to cause the lock bolt communicating with the actuator to advance towards the lower end of the upper steering shaft from a locked position to an unlocked position, respectively.

Abstract: A steering lock mechanism having an actuator communicating with a lock bolt is provided allowing for more space in the vicinity where a steering wheel is supported by an upper steering shaft. Additionally, a bolt engaging device is supported adjacent a lower end of the upper steering shaft in a position to engage a lock bolt such that any torque forces transmitted through the bolt engaging device will not cause damage to either the device or other components of the steering column. The actuator is rotated about an axis from a first position to a second position to cause the lock bolt communicating with the actuator to advance towards the lower end of the upper steering shaft from a locked position to an unlocked position, respectively.