Patents by Inventor Kurt Faber
Kurt Faber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190127769Abstract: There is provided a method of producing at least one unsaturated amino acid from at least one amino acid comprising at least two carbonyl groups, the method comprising (a) contacting a recombinant microbial cell with a medium comprising the amino acid comprising the carbonyl groups, wherein the cell is genetically modified to comprise—at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E) selected from the CYP152 10 peroxygenase family, and—at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein.Type: ApplicationFiled: May 3, 2017Publication date: May 2, 2019Applicant: EVONIK DEGUSSA GMBHInventors: Thomas HAAS, Anja HECKER, Thomas BÜLTER, Wolfgang KROUTIL, Kurt FABER
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Patent number: 9885060Abstract: The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, and at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein, wherein the short chain fatty acid is a C4-C10 fatty acid.Type: GrantFiled: February 25, 2016Date of Patent: February 6, 2018Assignee: Evonik Degussa GmbHInventors: Alexander Dennig, Kurt Faber, Melanie Hall, Thomas Haas, Thomas Buelter, Stefan Gilch, Anja Thiessenhusen
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Publication number: 20160326549Abstract: The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, and at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein, wherein the short chain fatty acid is a C4-C10 fatty acid.Type: ApplicationFiled: February 25, 2016Publication date: November 10, 2016Applicant: Evonik Degussa GmbHInventors: Alexander DENNIG, Kurt FABER, Melanie Hall, Thomas Haas, Thomas Buelter, Stefan Gilch, Anja Thiessenhusen
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Publication number: 20160244790Abstract: A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidase cofactor, and (b) contacting the hydrocarbon produced in step a) with a biological agent having transaminase activity and a biological agent having cofactor-dependent amino acid dehydrogenase activity in the presence of amino acid dehydrogenase cofactor and the substrate amino acid of the amino acid dehydrogenase.Type: ApplicationFiled: March 17, 2016Publication date: August 25, 2016Applicant: Evonik Degussa GmbHInventors: Thomas HAAS, Jan Christoph Pfeffer, Kurt Faber, Michael Fuchs
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Publication number: 20140120587Abstract: A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidase cofactor, and (b) contacting the hydrocarbon produced in step a) with a biological agent having transaminase activity and a biological agent having cofactor-dependent amino acid dehydrogenase activity in the presence of amino acid dehydrogenase cofactor and the substrate amino acid of the amino acid dehydrogenase.Type: ApplicationFiled: January 10, 2012Publication date: May 1, 2014Applicant: Evonik Degussa GmbHInventors: Thomas Haas, Jan Christoph Pfeffer, Kurt Faber, Michael Fuchs
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Patent number: 8709767Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.Type: GrantFiled: October 23, 2012Date of Patent: April 29, 2014Assignee: BASF SEInventors: Stephan Maurer, Bernhard Hauer, Melanie Bonnekessel, Kurt Faber, Clemens Stückler
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Patent number: 8597915Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.Type: GrantFiled: February 1, 2011Date of Patent: December 3, 2013Assignee: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Clemens Stückler, Kurt Faber
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Publication number: 20130045513Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.Type: ApplicationFiled: October 23, 2012Publication date: February 21, 2013Applicant: BASF SEInventors: Stephan Maurer, Bernhard Hauer, Melanie Bonnekessel, Kurt Faber, Clemens Stückler
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Publication number: 20120301931Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.Type: ApplicationFiled: February 1, 2011Publication date: November 29, 2012Applicant: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Clemens Stückler, Kurt Faber
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Patent number: 8313923Abstract: A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.Type: GrantFiled: November 13, 2007Date of Patent: November 20, 2012Assignee: BASF SEInventors: Rainer Stürmer, Bernhard Hauer, Thomas Friedrich, Kurt Faber, Melanie Hall
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Patent number: 8153408Abstract: A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.Type: GrantFiled: January 31, 2007Date of Patent: April 10, 2012Assignee: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Bettina M. Nestl, Wolfgang Kroutil, Kurt Faber
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Publication number: 20120070867Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O-C1-C6-alkyl , —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.Type: ApplicationFiled: May 31, 2010Publication date: March 22, 2012Applicant: BASF SEInventors: Steffen Maurer, Bemhard Hauer, Melanie Bonnekesse, Kurt Faber, Clemens Stückler
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Publication number: 20100304448Abstract: A method for the enzymatic preparation of amino acids of the general formula (3) or (4) from alpha-dehydroamino acids of the general formula (1) or (2) wherein R1, R2 are independently of one another H, C1-C6 alkyl, C2-C6 alkenyl, an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or an alkylaryl radical, or a carboxyl radical (—COOR), R3 is H, formyl, acetyl, propionyl, benzyl, benzyloxycarbonyl, BOC, Alloc, R is H, C1-C6 alkyl, aryl, by reducing a compound of the formula (1) or (2) in the presence of a reductase.Type: ApplicationFiled: December 8, 2008Publication date: December 2, 2010Inventors: Rainer Stürmer, Bernhard Hauer, Thomas Friedrich, Kurt Faber, Melanie Hall, Clemens Stückler
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Patent number: 7829324Abstract: The present invention relates to a method for the microbiological isomerization of alpha-hydroxycarboxylic acids using an alpha-hydroxycarboxylic acid racemase, the enzymes used for this method and microorganisms which express a suitable racemase activity, a screening method for microorganisms with alpha-hydroxycarboxylic acid racemase activity, the nucleic acid sequences encoding this enzyme, expression vectors, recombinant microorganisms which express this racemase, and methods for the production or isolation of a protein with alpha-hydroxycarboxylic acid racemase activity.Type: GrantFiled: June 17, 2004Date of Patent: November 9, 2010Assignee: BASF SEInventors: Silvia Glück, Barbara Schnell, Monika Pirker, Kurt Faber
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Patent number: 7795004Abstract: A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.Type: GrantFiled: April 19, 2007Date of Patent: September 14, 2010Assignee: BASF SEInventors: Rainer Stürmer, Wolfgang Kroutil, Kurt Faber, Christian Gruber
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Publication number: 20100035315Abstract: A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.Type: ApplicationFiled: November 13, 2007Publication date: February 11, 2010Applicant: BASF SEInventors: Rainer Stürmer, Bernhard Hauer, Thomas Friedrich, Kurt Faber, Melanie Hall
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Publication number: 20090221046Abstract: A process for the racemisation of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.Type: ApplicationFiled: January 31, 2007Publication date: September 3, 2009Applicant: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Bettina M. Nestl, Wolfgang Kroutil, Kurt Faber
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Patent number: 7569375Abstract: The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.Type: GrantFiled: September 18, 2003Date of Patent: August 4, 2009Assignee: Codexis, Inc.Inventors: Wolfgang Stampfer, Birgit Kosjek, Wolfgang Kroutil, Kurt Faber, Jürgen Eck, Frank Niehaus
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Publication number: 20090098623Abstract: A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.Type: ApplicationFiled: April 19, 2007Publication date: April 16, 2009Applicant: BASF SEInventors: Rainer Sturmer, Wolfgang Kroutil, Kurt Faber, Christian Gruber
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Publication number: 20040157305Abstract: The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.Type: ApplicationFiled: September 18, 2003Publication date: August 12, 2004Inventors: Wolfgang Stampfer, Birgit Kosjek, Wolfgang Kroutil, Kurt Faber, Jurgen Eck, Frank Niehaus