Patents by Inventor Kwan Hyi Lee
Kwan Hyi Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240011996Abstract: The present disclosure relates to a biomarker for diagnosis of prostate cancer and use of the biomarker. According to a biomarker composition for diagnosis of prostate cancer of the present disclosure, an optimal biomarker combination capable of effectively diagnosing prostate cancer has been discovered, and there is an advantage in that prostate cancer can be diagnosed with high accuracy by using the biomarker combination and a machine learning algorithm model.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Ho Jun KIM, Youngdo JEONG, Sungwook PARK
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Publication number: 20240002945Abstract: The present disclosure relates to a biosensor with surface-modified with reduced graphene oxide and a detection method using the same. The biosensor according to an aspect can effectively detect a target material in a urine sample, and thus, the use of the biosensor has an advantage in that prostate cancer can be diagnosed in a non-invasive, fast, and accurate manner.Type: ApplicationFiled: November 18, 2021Publication date: January 4, 2024Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Youngdo JEONG, Ho Jun KIM, Sungwook PARK, Seongchan KIM
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Publication number: 20210130613Abstract: Provided are positively charged nanoparticles and use thereof. According to the nanoparticles of an aspect, cucurbituril may limit electrostatic attraction between a guest for cucurbituril and a metal salt, thereby generating nanoparticles with a uniform size. Accordingly, the nanoparticles may have an effect of being capable of efficient intracellular gene delivery.Type: ApplicationFiled: April 22, 2020Publication date: May 6, 2021Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Youngdo JEONG, Kwan Hyi LEE, Hyojin LEE
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Patent number: 10739301Abstract: Provided is a field-effect transistor that can reduce noise, be produced by a simplified manufacturing method, and also have a plurality of active patterns and gate patterns designed to be combinable according to a detection purpose. The field-effect transistor includes a lower silicon layer and a buried oxide layer disposed on the lower silicon layer; an active pattern disposed on the buried oxide layer and including a channel region, a source region, and a drain region; a gate pattern disposed on the active pattern to at least partially overlap the active pattern; a source electrode disposed in direct contact with the source region on the active pattern, and a drain electrode disposed in direct contact with the drain region on the active pattern; and a gate insulating film disposed between the active pattern and the gate pattern.Type: GrantFiled: August 24, 2017Date of Patent: August 11, 2020Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi Lee, Minhong Jeun, Seok Lee, Sang Kyung Kim, Sungwook Park
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Publication number: 20200123271Abstract: Provided is a composition for enhancing the sensitivity of prostate cancer to an anti-cancer drug. The composition may overcome resistance of cancer cells to a target anti-cancer drug and improve not only sensitivity of the cancer cells to the anti-cancer drug but also therapeutic effects on prostate cancer via combined administration with a conventional target anti-cancer drug.Type: ApplicationFiled: October 7, 2019Publication date: April 23, 2020Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Hyojin LEE
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Publication number: 20190204321Abstract: The present invention relates to a high-sensitivity liquid field-effect sensor for colon cancer, applicable to a sample such as blood or stool. The sensor according to one aspect enables ultra-high precision/low-concentration detection of colon cancer biomarkers, thereby having an effect of enabling early diagnosis of colon cancer even with a very small amount of a sample.Type: ApplicationFiled: July 20, 2017Publication date: July 4, 2019Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATIONInventors: Kwan Hyi LEE, Min Hong JEUN, Sung Wook PARK, Seung Jae MYUNG, Choung Soo KIM, Sang Yeob KIM, Eun Ju DO, Ja Young KANG
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Publication number: 20180364194Abstract: Provided is a field-effect transistor that can reduce noise, be produced by a simplified manufacturing method, and also have a plurality of active patterns and gate patterns designed to be combinable according to a detection purpose. The field-effect transistor includes a lower silicon layer and a buried oxide layer disposed on the lower silicon layer; an active pattern disposed on the buried oxide layer and including a channel region, a source region, and a drain region; a gate pattern disposed on the active pattern to at least partially overlap the active pattern; a source electrode disposed in direct contact with the source region on the active pattern, and a drain electrode disposed in direct contact with the drain region on the active pattern; and a gate insulating film disposed between the active pattern and the gate pattern.Type: ApplicationFiled: August 24, 2017Publication date: December 20, 2018Inventors: Kwan Hyi LEE, Minhong JEUN, Seok LEE, Sang Kyung KIM, Sungwook PARK
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Publication number: 20170219518Abstract: Provided is a semiconductor-based ion-responsive urine sensor (IRUS) capable of detecting an analyte in urine by a non-invasive method. When a urine sensor according to an aspect is used, it is possible to diagnose a patient accurately in a comfortable condition and to use the urine sensor for point-of-care (POC) diagnosis.Type: ApplicationFiled: December 7, 2016Publication date: August 3, 2017Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATIONInventors: Kwan Hyi LEE, Min Hong JEUN, Sung Wook PARK, Seung Jae MYUNG, Choung Soo KIM, In Gab JEONG, Sang Hoon SONG
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Patent number: 9645141Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.Type: GrantFiled: November 29, 2013Date of Patent: May 9, 2017Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi Lee, Ho Young Park, Yu Chan Kim, Hyun Kwang Seok, Seok Lee
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Publication number: 20160202208Abstract: A multiplexing detection system of a dual gate ion-sensitive field effect transistor bio sensor of the present invention includes: a first dual gate ion-sensitive field effect transistor bio sensor; and a second dual gate ion-sensitive field effect transistor bio sensor, wherein a first bio signal is sensed through the first dual gate ion-sensitive field effect transistor bio sensor, and a second bio signal is sensed through the second dual gate ion-sensitive field effect transistor bio sensor, and the first bio signal and the second bio signal are different in type from each other.Type: ApplicationFiled: October 28, 2015Publication date: July 14, 2016Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Seok LEE, Minhong JEUN, Inkyu LEE, Jung Hoon PARK, Won-Ju CHO, Hyun-June JANG
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Publication number: 20160041172Abstract: The present disclosure relates to a composition or a kit that can be used for detection or diagnosis of various diseases.Type: ApplicationFiled: September 15, 2014Publication date: February 11, 2016Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Hyun Kwang Seok, Seok Lee, Gunhyuk Jang, Minhong Jeun
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Publication number: 20150198532Abstract: The invention relates to a biomarker detecting probe which is capable of early detection of a biomarker and precise quantification thereof at the same time, and a method of detecting a biomarker using the same. More particularly, it relates to a biomarker detecting probe comprising a ferritin protein, and a targeting antibody linked with a fluorescent material, superparamagnetic nano particle, and conductive particle, and a method of detecting a biomarker using the same.Type: ApplicationFiled: May 30, 2014Publication date: July 16, 2015Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Minhong JEUN, Yu Chan KIM, Seok LEE, Hyun Kwang SEOK
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Publication number: 20150044665Abstract: The present invention relates to a target-specific probe containing T7 bacteriophage with a targeting antibody, and a detection method or a detection kit for a biomarker using the target-specific probe. The biomarker can be detected by using the genetically-modified T7 bacteriophage expressing various heterogeneous proteins and peptides on its surface and antibody-antigen specific reaction which can make the probe targeted to a biomarker or bacteria; and a detectable labeling agent, for example a quantum dot.Type: ApplicationFiled: October 23, 2013Publication date: February 12, 2015Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan-Hyi LEE, Jong-Hoon CHOI, Jong-Wook LEE, Hyun-Kwang SEOK, Mintai Peter HWANG, Jang-won SONG
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Publication number: 20140302527Abstract: This invention relates to a target-specific probe containing a ferritin fusion protein and a targeting agent, a target-specific imaging probe containing a labeling agent coupled to the target-specific probe, and a detection method or detection kit of a biomarker using these probes.Type: ApplicationFiled: May 22, 2013Publication date: October 9, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan-Hyi LEE, Jong-Hoon Choi, Mintai Peter Hwang, Yu-Chan Kim, Jong-Wook Lee, Hyun-Kwang Seok
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Publication number: 20140170767Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.Type: ApplicationFiled: November 29, 2013Publication date: June 19, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwan Hyi LEE, Ho Young PARK, Yu Chan KIM, Hyun Kwang SEOK, Seok LEE
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Publication number: 20140030193Abstract: Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. Disclosed herein are functionalized quantum dots exhibiting greater stability in water, methods of making the functionalized quantum dots and methods of in vivo imaging using the functionalized quantum dots.Type: ApplicationFiled: April 11, 2012Publication date: January 30, 2014Applicant: The Johns Hopkins UniversityInventors: Peter C. Searson, Justin Galloway, Kwan Hyi Lee, Jea Ho Park
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Publication number: 20120100560Abstract: Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes quantitative profiling, spatial mapping, and multiplexing of cancer biomarkers using functionalized quantum dots. This approach provides highly selective targeting molecular markers for pancreatic cancer with extremely low levels of non-specific binding and provides quantitative spatial information of biomarker distribution on a single cell, which is important since tumors cell populations are inherently heterogeneous. The quantitative measurements (number of molecules per square micron) is validated using flow cytometry and demonstrated using multiplexed quantitative profiling using color-coded quantum dots.Type: ApplicationFiled: July 25, 2011Publication date: April 26, 2012Applicant: The Johns Hopkins UniversityInventors: Peter C. Searson, Kwan Hyi Lee, Konstantinos Konstantopoulos, ZiQiu Tong
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Publication number: 20070023105Abstract: The present invention relates to a CoPtP thin film having very high perpendicular magnetic anisotropy and a method for manufacturing the same. The method for manufacturing a CoPtP alloy thin film according to the present invention includes the steps of preparing an electroplating solution including CoSO4·7 H2O at 0.05˜0.2 M, H2PtCl6 at 0.005˜0.02 M, and NaH2PO2 at 0.01˜0.4 M, and dipping a basic material into the electroplating solution and forming the CoPtP alloy thin film on the basic material by electroplating at a low temperature.Type: ApplicationFiled: December 29, 2005Publication date: February 1, 2007Inventors: Won-Young Jeung, Kwan-Hyi Lee, Ho-Dong Park
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Patent number: 7095070Abstract: In a method for fabricating a Bi thin film having a great MR (magnetoresistance) at room temperature and a method for fabricating a spintronics device using the same, the Bi thin film is fabricated by an electrodepostiting method and a sputtering method and has very great MR characteristics at room temperature, and it can be applied to various spintronics devices.Type: GrantFiled: March 12, 2004Date of Patent: August 22, 2006Assignee: Korea Institute of Science and TechnologyInventors: Woo Young Lee, Kyung Ho Shin, Suk Hee Han, Joon Yeon Chang, Hi Jung Kim, Dal Young Kim, Kwan Hyi Lee, Kyoung Il Lee, Min Hong Jeun
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Publication number: 20040179309Abstract: In a method for fabricating a Bi thin film having a great MR (magnetoresistance) at room temperature and a method for fabricating a spintronics device using the same, the Bi thin film is fabricated by an electrodepostiting method and a sputtering method and has very great MR characteristics at room temperature, and it can be applied to various spintronics devices.Type: ApplicationFiled: March 12, 2004Publication date: September 16, 2004Applicant: Korea Institute of Science and TechnologyInventors: Woo Young Lee, Kyung Ho Shin, Suk Hee Han, Joon Yeon Chang, Hi Jung Kim, Dal Young Kim, Kwan Hyi Lee, Kyoung Il Lee, Min Hong Jeun