Abstract: Disclosed are a genetically modified microorganism that can produce 3-hydroxyadipic acid and/or ?-hydromuconic acid in high yields, and the genetically modified microorganism. The genetically modified microorganism is a microorganism having an ability to produce 3-hydroxyadipic acid and/or ?-hydromuconic acid, in which the reaction to generate acetyl-CoA from pyruvic acid is enhanced and function of pyruvate kinase and/or phosphotransferase system is reduced.

Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed.

Abstract: A genetically modified microorganism that can produce 3-hydroxyadipic acid and/or ?-hydromuconic acid with a high yield; and a method of producing 3-hydroxyadipic acid and/or ?-hydromuconic acid using the genetically modified microorganism, are disclosed. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid and/or ?-hydromuconic acid, and has an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.

Abstract: Disclosed are a genetically modified microorganism with an ability to produce 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid in high yield, and a method of producing 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid by using the genetically modified microorganism. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid, ?-hydromuconic acid, and/or adipic acid and is deficient in the function of pyruvate kinase, in which the activities of phosphoenolpyruvate carboxykinase and of an enzyme that catalyzes the reaction of reducing 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA are enhanced.

Abstract: Disclosed is a genetically modified microorganism that produces 3-hydroxyadipic acid, ?-hydromuconic acid. or adipic acid in high yield. A nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or the expression of the polypeptide is enhanced and the function of pyruvate kinase is impaired in the genetically modified microorganism: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 7; (b) a polypeptide having the same amino acid sequence as any one of those amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, andor added, and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA; (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of those amino acid sequences and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.

Abstract: Provided is a method of producing ?-hydromuconic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing ?-hydromuconic acid.

Abstract: A method of producing ?-hydromuconic acid using a metabolic pathway of a microorganism is disclosed. The method of producing ?-hydromuconic acid includes the step of culturing at least one type of microorganism having a capacity to produce ?-hydromuconic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Delftia, and microorganisms belonging to the genus Shimwellia.

Abstract: Provided is a method of producing 3-hydroxyadipic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing 3-hydroxyadipic acid.

Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed.

Abstract: A novel method of producing 3-hydroxyadipic acid using a metabolic pathway of a microorganism is disclosed.

Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed.

Abstract: Disclosed is a genetically modified microorganism into which a nucleic acid encoding an enzyme that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA is introduced. In the genetically modified microorganism, a nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or expression of the polypeptide is enhanced: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 6 and 213, (b) a polypeptide composed of the same amino acid sequence as any one of the amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, and/or added, and having enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, and (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of the amino acid sequences and having activity to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.

Abstract: Provided is a method of producing ?-hydromuconic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing ?-hydromuconic acid.

Abstract: A method of producing 2,3-butanediol includes subjecting a 2,3-butanediol culture liquid produced by microbial fermentation to nanofiltration membrane treatment and ion-exchange treatment (Step A), and then adding an alkaline substance and performing distillation (Step B).

Abstract: Provided is a method of producing 3-hydroxyadipic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing 3-hydroxyadipic acid.

Abstract: A method produces a chemical product by continuous fermentation including filtering a culture liquid of a microorganism(s) through a separation membrane, retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid, adding a fermentation feedstock to the culture liquid, and recovering a product in the filtrate, wherein the microorganism(s) is/are a microorganism(s) that undergo(es) catabolite repression, and the fermentation feedstock comprises hexose and pentose.

Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed.

Abstract: A method of producing 2,3-butanediol includes the steps of: culturing a microorganism belonging to the genus Zymobacter in a fermentation feedstock containing a carbon source (Step A); and purifying 2,3-butanediol from culture liquid obtained in this step (Step B). In this method, the carbon source contains pentose, and the microorganism belonging to the genus Zymobacter has a capacity to metabolize pentose.

Abstract: A method of producing ?-hydromuconic acid using a metabolic pathway of a microorganism is disclosed. The method of producing ?-hydromuconic acid includes the step of culturing at least one type of microorganism having a capacity to produce ?-hydromuconic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Delftia, and microorganisms belonging to the genus Shimwellia.

Abstract: A novel method of producing 3-hydroxyadipic acid using a metabolic pathway of a microorganism is disclosed.