Patents by Inventor Kyoichiro Saitoh

Kyoichiro Saitoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pradimicins l and fl, and derivatives thereof
    Patent number: 5843908
    Abstract: The present invention relates to novel antifungal antibiotics herein designated as pradimicin L and pradimicin FL, and derivatives thereof. Pradimicins L and FL are produced by Actinomadura verrucosospora subsp. neohibisca strain R103-3, ATCC No. 53930.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: December 1, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Kyoichiro Saitoh, Masami Hatori, Takeo Miyaki, Toshikazu Oki, Koji Tomita
  • Production of pradimicin antibiotics
    Patent number: 5194371
    Abstract: The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: March 16, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tamotsu Furumai, Masami Hatori, Masatoshi Kakushima, Chiharu Ikeda, Kyoichiro Saitoh, Seikichi Kobaru
  • Dynemicin C antibiotic, its triacetyl derivative and pharmaceutical composition containing same
    Patent number: 5162330
    Abstract: The novel antitumor antibiotic designated herein as dynemicin C is produced by fermentation of Micromonospora chersina M956-1 mutant F1085 (ATCC-55077). Dynemicin C and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: November 10, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Kyoichiro Saitoh, Takeo Miyaki, Haruaki Yamamoto, Nahomi Oda
  • Antifungal antibiotics
    Patent number: 5110960
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: May 5, 1992
    Assignee: Bristol-Myers Company
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Antifungal antibiotics
    Patent number: 4990497
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: February 5, 1991
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Antifungal antibiotics
    Patent number: 4870165
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: September 26, 1989
    Assignee: Bristol-Myers Company
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • BBM-1675, a new antitumor antibiotic complex
    Patent number: 4868117
    Abstract: A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit both antimicrobial activity and antitumor activity.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: September 19, 1989
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Kyoichiro Saitoh, Hiroaki Ohkuma, Hiroshi Kawaguchi
  • Boholmycin antibiotic
    Patent number: 4792545
    Abstract: Boholmycin antibiotic is prepared by fermentation of Streptomyces hygroscopicus H617-25 (ATCC No. 53240) in a nutrient medium preferably comprising glycerol, bacto-liver, cornsteep liquor, ammonium sulfate, sodium chloride and calcium carbonate. The antibiotic and pharmaceutically acceptable salts and hydrates thereof and compositions containing these are effective against Gram-positive, Gram-negative and acid-fast bacteria and against bacterial strains which are resistant to previously known aminoglycoside antibiotics and are useful to treat bacterial infections in mammals.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: December 20, 1988
    Assignee: Bristol-Myers Company
    Inventors: Kyoichiro Saitoh, Mitsuaki Tsunakawa, Masataka Konishi, Takeo Miyaki
  • Boxazomycin A and B, new antibiotics containing benzoxazole nucleus
    Patent number: 4728612
    Abstract: The novel antibiotics boxazomycin A and B, which have the formula: ##STR1## wherein R is --CH.sub.2 OH for boxazomycin A; and R is --CH.sub.3 for boxazomycin B. These new antibiotics, which are produced by cultivating a novel strain of Pseudonocardia (ATCC 53205), inhibit growth of aerobic Gram-positive bacteria and anaerobes with enhanced activity observed in acidic medium.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: March 1, 1988
    Assignee: Bristol Myers Company
    Inventors: Kyoichiro Saitoh, Masataka Konishi, Koji Tomita
  • Antitumor antibiotic complex
    Patent number: 4708872
    Abstract: A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit both antimicrobial activity and antitumor activity.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: November 24, 1987
    Assignee: Bristol-Meyers Company
    Inventors: Masataka Konishi, Kyoichiro Saitoh, Hiroaki Ohkuma, Hiroshi Kawaguchi
  • Boxazomycin A and B, new antibiotics containing benzoxazole nucleus
    Patent number: 4690926
    Abstract: The novel antibiotics boxazomycin A and B, which have the formula: ##STR1## wherein R is --CH.sub.2 OH for boxazomycin A; and R is --CH.sub.3 for boxazomycin B. These new antibiotics, which are produced by cultivating a novel strain of Pseudonocardia (ATCC 53205), inhibit growth of aerobic Gram-positive bacteria and anaerobes with enhanced activity observed in acidic medium.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: September 1, 1987
    Assignee: Bristol-Myers Company
    Inventors: Kyoichiro Saitoh, Masataka Konishi, Koji Tomita
  • BBM-1675, a new antibiotic complex
    Patent number: 4675187
    Abstract: A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit antimicrobial activity and also antitumor activity in certain mouse tumor systems.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: June 23, 1987
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Kyoichiro Saitoh, Hiroaki Ohkuma, Hiroshi Kawaguchi