Abstract: A hot-rolled steel sheet comprises, by wt %, 0.1-0.25% of carbon (C), 0.2-2.0% of manganese (Mn), 0.3% or less of silicon (Si), 0.05% or less of aluminum (Al), 0.05% or less of phosphorous (P), 0.03% or less of sulfur (S), 0.01% or less of nitrogen (N), 0.005 to 0.05% of titanium (Ti), 0.0005 to 0.005% of boron (B), 0.01% or less of niobium (Nb), 0.1% or less of molybdenum (Mo), 0.1% or less of vanadium (V), and the balance of iron (Fe) and inevitable impurities, comprises, in a microstructure, 55-90% of bainite and 10-45% of ferrite by volume fraction, the number per unit area of carbides having a major axis length of 25-500 nm from among carbides present in the bainite is 3*106/mm2 or more, and the average aspect ratio (major axis/minor axis) of the carbides present in the bainite can be 2.0 or less.

Abstract: A process control system according to one embodiment of the present invention comprises: a first system for generating thickness information about an internal defect layer included in a carbon steel product; and a second system which receives the thickness information about the internal defect layer from the first system through a network, and which controls an etching process for removing at least a part of the internal defect layer from the carbon steel product by using the thickness information about the internal defect layer, wherein the first system provides the second system with a calculation module necessary for the second system to control the etching process, and the second system provides the first system with the information necessary for the first system to update the calculation module.

Abstract: A steel sheet with excellent surface quality, and a manufacturing method therefor are provided. The present invention provides a pickled steel sheet with excellent surface quality, comprising, by wt %, carbon (C) in an amount greater than or equal to 0.05% and less than 0.4%, 0.5% or less of silicon (Si) (excluding 0%), 0.05% or less of phosphorus (P), 0.03% or less of sulfur (S), 0.01% or less of boron (B), 0.1-2.5% of manganese (Mn) and/or chromium (Cr), and the balance of iron (Fe) and inevitable impurities, wherein the average thickness of an internal oxide layer and/or a tantalum layer, which are formed on the surface layer of the steel sheet, is 1-10 ?m, and the standard deviation of the thickness of the internal oxide layer and/or the tantalum layer in the length direction of the steel sheet is 2 ?m or less.

Abstract: Provided are a high-carbon steel sheet having good surface quality and a manufacturing method therefor. The present invention provides a high-carbon pickled steel sheet having good surface quality, the steel sheet containing, in weight %, 0.4% or more and less than 1.2% of carbon (C), 0.5% or less (excluding 0%) of silicon (Si), 0.05% or less of phosphorus (P), 0.03% or less of sulfur (S), 0.1 to 2.5% of at least one of manganese (Mn) and chromium (Cr), and the balance of iron (Fe) and inevitable impurities, wherein the average thickness of an internal oxide layer and/or a decarburized layer formed in a surface layer portion of the steel sheet is 1 to 10 ?m and the standard deviation of the thickness of the internal oxide layer and/or the decarburized layer in the length direction of the steel sheet is 2 ?m or less.

Abstract: The present disclosure provides ghost nanovesicles (gNVs) that are deficient in cytosolic components. Methods of making such vesicles and therapeutic uses of such vesicles are also provided. The gNVs may be used in preventing or treating conditions that may benefit from administration of the gNVs. Such conditions include conditions that involve inflammation.

Abstract: Non-naturally occurring vesicles derived from bacteria, e.g., pathogenic bacteria, methods for making the vesicles, and methods for using compositions of these vesicles are disclosed. Methods of using the vesicles include prevention and/or treatment of bacterial infections. Also provided herein are compositions that include vesicles derived front bacteria and tumor vesicles, methods for making the tumor vesicles, and methods for using the compositions of bacterial vesicles and tumor vesicles. Methods of using the compositions of bacterial vesicles and tumor vesicles include treatment of cancer in a subject. Tumor vesicles may be derived from cancer cells present in the subject to be treated or from a cancer cell line expressing at least one neoantigen. The neoantigen may be specific to the subject and may have been identified by sequencing of the cancer cells from the subject. The neoantigen may be a neoantigen known to be commonly expressed in a particular type of cancer.

Abstract: A high strength hot-rolled steel sheet having an excellent hole expansion ration comprises, by weight %, 0.12% or more and less than 0.30% of carbon (C), 0.1-2.5% of manganese (Mn), 0.5% or less of silicon (Si) (not including 0%), 0.0005-0.005% of boron (B), 0.02% or less of phosphorous (P), 0.01% or less of sulfur (S), and the balance being iron (Fe) and unavoidable impurities, and comprises 95 volume % or more of martensite as a microstructure. And the product of the tensile strength (TS) and hole expansion ratio (HER) can be 30,000 MPa % or greater.

Abstract: The invention relates to a steel sheet for tool, and method for manufacturing thereof. An embodiment of the present invention is a steel sheet for a tool comprising 0.4 to 0.6 wt % of C, 0.05 to 0.5 wt % of Si, 0.1 to 1.5 wt % of Mn, 0.05 to 0.5 wt % of V, 0.1 to 2.0 wt % of at least of one or two components selected from the group comprising Ni, Cr, Mo, and combinations thereof, and the balance of Fe and inevitable impurities, with respect to 100 wt % of the total steel sheet, and provides a steel sheet for a tool of which the deviation of Rockwell hardness by the position in the width direction is within 5 HRC, and the ratio of those having a wave height in the longitudinal direction within 20 cm is 90% or more with respect to the wave height per 1 m of the steel sheet comprising the central portion in the longitudinal direction of the steel sheet for a tool.

Abstract: Provided is a high-strength hot-rolled plated steel sheet, including: in a unit of wt %, C at 0.05-0.5 wt %, Mn at 0.1-3.s0 wt %, Si at 0.5 wt % or less (excluding 0 wt %), P at 0.05 wt % or less (excluding 0 wt %), S at 0.03 wt % or less (excluding 0 wt %), Nb at 0.01 wt % or less (excluding 0 wt %), B at 0.0005-0.005 wt %, Ti at 0.005-0.2 wt %, and the remainder of Fe and inevitable impurities, wherein a microstructure thereof includes, as a volume fraction, 90 vol % or more of tempered martensite and 5 vol % or less of one crystal phase of bainite, ferrite, pearlite, and residual austenite; a tensile strength thereof is 650 MPa or more, and a yield strength thereof is 550 MPa or more; and as a ratio of the strengths, a yield ratio (yield strength/tensile strength) is 0.85 or more.

Abstract: The invention relates to methods for production of extracellular vesicle-mimetic nanovesicles from mesenchymal stem cells to treat or prevent inflammatory related conditions or diseases. Included with the invention are pharmaceutical compositions comprising extracellular vesicle-mimetic nanovesicles derived from mesenchymal stem cells for the treatment or prevention of inflammatory related conditions.

Abstract: Disclosed are a quenched steel sheet and a method for manufacturing the same. The quenched steel sheet according to an aspect of the present invention contains, in terms of wt %, C: 0.05˜0.25%, Si: 0.5% or less (excluding 0), Mn: 0.1˜2.0%, P: 0.05% or less, S: 0.03% or less, the remainder Fe, and other unavoidable impurities, wherein a refined structure of the steel sheet comprises 90 volume % or more of martensite with a first hardness and martensite with a second hardness.

Abstract: Disclosed are a quenched steel sheet and a method for manufacturing the same. The quenched steel sheet according to an aspect of the present invention contains, in terms of wt %, C: 0.05˜0.25%, Si: 0.5% or less (excluding 0), Mn: 0.1˜2.0%, P: 0.05% or less, S: 0.03% or less, the remainder Fe, and other unavoidable impurities, wherein a refined structure of the steel sheet comprises 90 volume % or more of martensite with a first hardness and martensite with a second hardness.

Abstract: The invention relates to a steel sheet for tool, and method for manufacturing thereof. An embodiment of the present invention is a steel sheet for a tool comprising 0.4 to 0.6 wt % of C, 0.05 to 0.5 wt % of Si, 0.1 to 1.5 wt % of Mn, 0.05 to 0.5 wt % of V, 0.1 to 2.0 wt % of at least of one or two components selected from the group comprising Ni, Cr, Mo, and combinations thereof, and the balance of Fe and inevitable impurities, with respect to 100 wt % of the total steel sheet, and provides a steel sheet for a tool of which the deviation of Rockwell hardness by the position in the width direction is within 5 HRC, and the ratio of those having a wave height in the longitudinal direction within 20 cm is 90% or more with respect to the wave height per 1 m of the steel sheet comprising the central portion in the longitudinal direction of the steel sheet for a tool.

Abstract: Disclosed are a quenched steel sheet and a method for manufacturing the same. The quenched steel sheet according to an aspect of the present invention contains, in terms of wt %, C: 0.05˜0.25%, Si: 0.5% or less (excluding 0), Mn: 0.1˜2.0%, P: 0.05% or less, S: 0.03% or less, the remainder Fe, and other unavoidable impurities, wherein a refined structure of the steel sheet comprises 90 volume % or more of martensite with a first hardness and martensite with a second hardness.

Abstract: Provided is a method of manufacturing a high-carbon hot-rolled steel sheet, including the steps of i) preparing high-carbon steel materials comprising C: 0.7 to 0.9%, Si: 0.5% or less, Mn: 0.1 to 1.5%, Cr: 0.5% or less, P: 0.05% or less, and S: 0.03% or less in wt % and remaining Fe and other inevitable impurities; ii) heating the high-carbon steel materials again and manufacturing a steel sheet by performing hot rolling in an austenite region in which a finishing temperature for the hot rolling is an Ar3 transformation temperature or higher; iii) rapidly cooling the steel sheet at 520 to 620° C. before phase transformation is started in a Run-Out Table (ROT); iv) uniformly maintaining a cooling retention temperature so that the cooled steel sheet is subject to phase transformation in any one temperature between 520 to 620° C.; and v) winding the steel sheet in the cooling retention temperature. Also provided is the high-carbon steel sheet made by the above-described method.

Abstract: Provided is a method of manufacturing a high-carbon hot-rolled steel sheet, including the steps of i) preparing high-carbon steel materials comprising C: 0.7 to 0.9%, Si: 0.5% or less, Mn: 0.1 to 1.5%, Cr: 0.5% or less, P: 0.05% or less, and S: 0.03% or less in wt % and remaining Fe and other inevitable impurities; ii) heating the high-carbon steel materials again and manufacturing a steel sheet by performing hot rolling in an austenite region in which a finishing temperature for the hot rolling is an Ar3 transformation temperature or higher; iii) rapidly cooling the steel sheet at 520 to 620° C. before phase transformation is started in a Run-Out Table (ROT); iv) uniformly maintaining a cooling retention temperature so that the cooled steel sheet is subject to phase transformation in any one temperature between 520 to 620° C.; and v) winding the steel sheet in the cooling retention temperature. Also provided is the high-carbon steel sheet made by the above-described method.

Abstract: A high carbon steel sheet having superior strength and ductility and a method for manufacturing the same comprising: 0.2 to 1.0 wt % carbon (C), 0 to 3.0 wt % silicon (Si), 0 to 3.0 wt % manganese (Mn), 0 to 3.0 wt % chromium (Cr), 0 to 3.0 wt % nickel (Ni), 0 to 0.5 wt % molybdenum (Mo), 0 to 3.0 wt % aluminum (Al), 0 to 0.01 wt % boron (B), 0 to 0.5 wt % titanium (Ti), and the remainder substantially being iron (Fe) and inevitable impurities. The contents of carbon, manganese, chromium, and nickel satisfy the following Equation 1, and the contents of silicon and aluminum satisfy the following Equation 2: (3.0?2.5×C)wt %?(Mn+Cr+Ni/2)?8.5 wt %—(Equation 1) Si+Al>1.0 wt % (Equation 2).

Abstract: A high carbon steel sheet having superior strength and ductility and a method for manufacturing the same comprising: 0.2 to 1.0 wt % carbon (C), 0 to 3.0 wt % silicon (Si), 0 to 3.0 wt % manganese (Mn), 0 to 3.0 wt % chromium (Cr), 0 to 3.0 wt % nickel (Ni), 0 to 0.5 wt % molybdenum (Mo), 0 to 3.0 wt % aluminum (Al), 0 to 0.01 wt % boron (B), 0 to 0.5 wt % titanium (Ti), and the remainder substantially being iron (Fe) and inevitable impurities. The contents of carbon, manganese, chromium, and nickel satisfy the following Equation 1, and the contents of silicon and aluminum satisfy the following Equation 2: (3.0?2.5×C)wt %?(Mn+Cr+Ni/2)?8.5 wt %—(Equation 1) Si+Al>1.0 wt % (Equation 2).

Abstract: The present invention relates to a high carbon steel sheet that is superior in fatigue life and a method of manufacturing the high carbon steel sheet. The high carbon steel sheet includes about 0.75 wt % to about 0.95 wt % of carbon, smaller than about 1.8 wt % of silicon, about 0.1 wt % to about 1.5 wt % of manganese, about 0.1 wt %˜1.0 wt % of chromium, smaller than about 0.02 wt % of phosphorus, smaller than about 0.02 wt % of sulfur, a residual amount of iron, and inevitable impurities. A layer interval between laminar carbides included in the high carbon steel sheet is smaller than about 0.5 ?m. The high carbon steel sheet may include a fine pearlite having a lamellar structure. The fine pearlite included in the high carbon steel sheet may have a volume percentage of larger than about 90%. A ratio of length to width of the lamellar structure may be larger than about 10:1.