Patents by Inventor Kyriakos Komvopoulos

Kyriakos Komvopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8927283
    Abstract: Methods for treating surfaces of polymeric substrates (as used in medical implants) with inert plasmas to promote the growth of bioentities (such as cells) on these surfaces is disclosed. The treated surfaces are subsequently exposed to an environment to form functionalities associated with enhanced growth of the bioentity on the surface. For example, the substrate may be exposed to the ambient environment. The bioentity may then be deposited on the modified surface. This inert plasma treatment and exposure to a suitable environment does not degrade the implants, and thus improved implants are created. Also, due to the specific functional groups at the modified surface, high cell densities are achieved.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: January 6, 2015
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Satomi Tajima
  • Publication number: 20130029421
    Abstract: Cell culture substrates are provided. Aspects of the cell culture substrate include a substrate with a surface having at least one hydrophilic region and at least one hydrophobic region, and a surfactant layer present on the surface of the substrate and configured to produce a cell-binding surface on the hydrophilic regions of the surface. Also provided are kits which include the cell culture substrate, as well as methods of producing the cell culture substrate. The cell culture substrate and methods described herein find use in a variety of applications, including single-cell culture applications.
    Type: Application
    Filed: July 26, 2012
    Publication date: January 31, 2013
    Inventors: Kyriakos Komvopoulos, Qian Cheng
  • Patent number: 8168074
    Abstract: Methods and systems for modifying a surface of a polymer with a shielded plasma are provided. The surface may be modified to create a surface with increased crosslinking and/or a particular mechanical property, such as a coefficient of friction. A shielding arrangement is used to modify the plasma to which the polymer surface is exposed, thereby providing a surface with the desired mechanical properties. In one aspect, a single source that provides multiple species of plasma particles is advantageously used instead of having to switch or move in multiple sources. The extent of crosslinking is evaluated using a surface force microscope to determine a frictional property that is correlated to the crosslinking, e.g., via calibrated values determined from reference surfaces.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: May 1, 2012
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Satomi Tajima
  • Patent number: 7879418
    Abstract: A method for forming a carbon-containing layer on a polymeric substrate is disclosed. The polymeric substrate is modified physically and chemically using an inductively coupled plasma process. The carbon-containing layer can be fluorocarbon film with different physicochemical properties and structure.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: February 1, 2011
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Satomi Tajima
  • Publication number: 20100190036
    Abstract: Provided are filtered cathodic vacuum arc systems useful for modifying a surface of a substrate (e.g. depositing a thin film of a material onto a surface of a substrate and/or implanting a material into the near-surface region of a substrate). The systems are configured to stabilize a do arc discharge plasma from an arc source. Also provided are methods for modifying a surface of a substrate, which in some cases includes depositing a material onto a surface of a substrate, in some cases includes implanting a material into the near-surface region of a substrate, and in some cases includes both depositing a material onto a surface of a substrate and implanting a material into the near-surface region of a substrate using the subject cathodic arc systems. In addition, magnetic recording media produced by the subject systems and methods are provided.
    Type: Application
    Filed: January 27, 2010
    Publication date: July 29, 2010
    Inventors: Kyriakos Komvopoulos, Hanshen Zhang, Charanjit Singh Bhatia
  • Publication number: 20090130164
    Abstract: Methods for treating surfaces of polymeric substrates (as used in medical implants) with inert plasmas to promote the growth of bioentities (such as cells) on these surfaces is disclosed. The treated surfaces are subsequently exposed to an environment to form functionalities associated with enhanced growth of the bioentity on the surface. For example, the substrate may be exposed to the ambient environment. The bioentity may then be deposited on the modified surface. This inert plasma treatment and exposure to a suitable environment does not degrade the implants, and thus improved implants are created. Also, due to the specific functional groups at the modified surface, high cell densities are achieved.
    Type: Application
    Filed: November 20, 2007
    Publication date: May 21, 2009
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyriakos Komvopoulos, Satomi Tajima
  • Publication number: 20090071939
    Abstract: Methods and systems for modifying a surface of a polymer with a shielded plasma are provided. The surface may be modified to create a surface with increased crosslinking and/or a particular mechanical property, such as a coefficient of friction. A shielding arrangement is used to modify the plasma to which the polymer surface is exposed, thereby providing a surface with the desired mechanical properties. In one aspect, a single source that provides multiple species of plasma particles is advantageously used instead of having to switch or move in multiple sources. The extent of crosslinking is evaluated using a surface force microscope to determine a frictional property that is correlated to the crosslinking, e.g., via calibrated values determined from reference surfaces.
    Type: Application
    Filed: September 18, 2008
    Publication date: March 19, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyriakos Komvopoulos, Satomi Tajima
  • Patent number: 6685743
    Abstract: The surface of a high molecular weight polymer such as high molecular weight polyethylene is modified in a localized manner by treatment with a plasma gas. The treatment produces a variety of useful results, depending on the gas used and the treatment conditions. One such result is crosslinking of the polymer in a localized manner at the surface to improve the durability of the surface against detrimental processes such as reorientation and alignment of the crystalline lamellae parallel to the contact surface which renders the surface susceptible to disintegration into particles. Another result is the chemical transformation of the surface for purposes such as increasing the hydrophilic or hydrophobic nature of the surface or coupling functional groups to the surface.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: February 3, 2004
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Catherine M. Klapperich, Lisa A. Pruitt, Stephen L. Kaplan
  • Publication number: 20030040807
    Abstract: The surface of a high molecular weight polymer such as high molecular weight polyethylene is modified in a localized manner by treatment with a plasma gas. The treatment produces a variety of useful results, depending on the gas used and the treatment conditions. One such result is crosslinking of the polymer in a localized manner at the surface to improve the durability of the surface against detrimental processes such as reorientation and alignment of the crystalline lamellae parallel to the contact surface which renders the surface susceptible to disintegration into particles. Another result is the chemical transformation of the surface for purposes such as increasing the hydrophilic or hydrophobic nature of the surface or coupling functional groups to the surface.
    Type: Application
    Filed: February 12, 2002
    Publication date: February 27, 2003
    Applicant: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Catherine M. Klapperich, Lisa A. Pruitt, Stephen L. Kaplan
  • Patent number: 6379741
    Abstract: The surface of a high molecular weight polymer such as high molecular weight polyethylene is modified in a localized manner by treatment with a plasma gas. The treatment produces a variety of useful results, depending on the gas used and the treatment conditions. One such result is crosslinking of the polymer in a localized manner at the surface to improve the durability of the surface against detrimental processes such as reorientation and alignment of the crystalline lamellae parallel to the contact surface which renders the surface susceptible to disintegration into particles. Another result is the chemical transformation of the surface for purposes such as increasing the hydrophilic or hydrophobic nature of the surface or coupling functional groups to the surface.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: April 30, 2002
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Catherine M. Klapperich, Lisa A. Pruitt, Stephen L. Kaplan
  • Patent number: 5851475
    Abstract: A process for producing an article with improved ceramic surface properties including providing an article having a ceramic surface, and placing the article onto a conductive substrate holder in a hermetic enclosure. Thereafter a low pressure ambient is provided in the hermetic enclosure. A plasma including ions of solid materials is produced the ceramic surface of the article being at least partially immersed in a macroparticle free region of the plasma. While the article is immersed in the macroparticle free region, a bias of the substrate holder is biased between a low voltage at which material from the plasma condenses on the surface of the article and a high negative voltage at which ions from the plasma are implanted into the article.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: December 22, 1998
    Assignees: Regents of the University of California, IBM
    Inventors: Kyriakos Komvopoulos, Ian G. Brown, Bo Wei, Simone Anders, Andre Anders, C. Singh Bhatia
  • Patent number: 5838522
    Abstract: Surface modification of magnetic recording heads using plasma immersion ion implantation and deposition is disclosed. This method may be carried out using a vacuum arc deposition system with a metallic or carbon cathode. By operating a plasma gun in a long-pulse mode and biasing the substrate holder with short pulses of a high negative voltage, direct ion implantation, recoil implantation, and surface deposition are combined to modify the near-surface regions of the head or substrate in processing times which may be less than 5 min. The modified regions are atomically mixed into the substrate. This surface modification improves the surface smoothness and hardness and enhances the tribological characteristics under conditions of contact-start-stop and continuous sliding. These results are obtained while maintaining original tolerances.
    Type: Grant
    Filed: February 3, 1997
    Date of Patent: November 17, 1998
    Assignee: The Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Ian G. Brown, Bo Wei, Simone Anders, Andre Anders, C. Singh Bhatia
  • Patent number: 5476691
    Abstract: Surface modification of magnetic recording heads using plasma immersion ion implantation and deposition is disclosed. This method may be carried out using a vacuum arc deposition system with a metallic or carbon cathode. By operating a plasma gun in a long-pulse mode and biasing the substrate holder with short pulses of a high negative voltage, direct ion implantation, recoil implantation, and surface deposition are combined to modify the near-surface regions of the head or substrate in processing times which may be less than 5 min. The modified regions are atomically mixed into the substrate. This surface modification improves the surface smoothness and hardness and enhances the tribological characteristics under conditions of contact-start-stop and continuous sliding. These results are obtained while maintaining original tolerances.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: December 19, 1995
    Assignees: International Business Machines, Inc., Regents of the University of California
    Inventors: Kyriakos Komvopoulos, Ian G. Brown, Bo Wei, Simone Anders, Andre Anders, Singh C. Bhatia
  • Patent number: 5308661
    Abstract: A process is disclosed for the pretreatment of a carbon-coated substrate to provide a uniform high density of nucleation sites thereon for the subsequent deposition of a continuous diamond film without the application of a bias voltage to the substrate. The process comprises exposing the carbon-coated substrate, in a microwave plasma enhanced chemical vapor deposition system, to a mixture of hydrogen-methane gases, having a methane gas concentration of at least about 4% (as measured by partial pressure), while maintaining the substrate at a pressure of about 10 to about 30 Torr during the pretreatment.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: May 3, 1994
    Assignee: The Regents of the University of California
    Inventors: Zhu Feng, Marilee Brewer, Ian Brown, Kyriakos Komvopoulos