Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: Provided are real time location tracking system and method of a wireless device using a wireless LAN AP, the system and method include measuring intensities of APs that are currently detected by the wireless device of which location is to be estimated, collecting ADD, constructing RDLE including locations, a list of APs corresponding to the locations, signal intensities of the APs, and reliabilities of the APs, storing the RDLE, comparing the RDLE with the ADD, and estimating the location of the wireless device, which realizes seamless location tracking technology indoors and outdoors, thereby providing a variety of location tracking services.

Abstract: Provided are real time location tracking system and method of a wireless device using a wireless LAN AP, the system and method include measuring intensities of APs that are currently detected by the wireless device of which location is to be estimated, collecting ADD, constructing RDLE including locations, a list of APs corresponding to the locations, signal intensities of the APs, and reliabilities of the APs, storing the RDLE, comparing the RDLE with the ADD, and estimating the location of the wireless device, which realizes seamless location tracking technology indoors and outdoors, thereby providing a variety of location tracking services.