Abstract: A detector compares a drain voltage with a first threshold voltage and outputs a first detection signal. An ON-counter detects a period of time during which current flows in a switching circuit based on the first detection signal, counts the period of time based on a predetermined clock cycle, and outputs an ON-count value. A first comparator receives the ON-count value and an ON-threshold value and outputs a first comparison signal when the ON-count value and the ON-threshold value match. A second comparator receives the ON-count value and a decreased ON threshold value, compares the ON-count value and the decreased ON-threshold value, and outputs a second comparison signal. An ON-mask time adjuster receives the second comparison signal and outputs an ON-threshold value for adjusting a mask time and a decreased ON-threshold value that is less than the ON threshold value.

Abstract: A detector compares a drain voltage with a first threshold voltage and outputs a first detection signal. An ON-counter detects a period of time during which current flows in a switching circuit based on the first detection signal, counts the period of time based on a predetermined clock cycle, and outputs an ON-count value. A first comparator receives the ON-count value and an ON-threshold value and outputs a first comparison signal when the ON-count value and the ON-threshold value match. A second comparator receives the ON-count value and a decreased ON threshold value, compares the ON-count value and the decreased ON-threshold value, and outputs a second comparison signal. An ON-mask time adjuster receives the second comparison signal and outputs an ON-threshold value for adjusting a mask time and a decreased ON-threshold value that is less than the ON threshold value.

Abstract: The present invention relates to a novel function of Msx1 protein for inhibiting tumor angiogenesis and metastasis by targeting mTOR (mammalian target of rapamycin) signaling pathway, and for treating a cancer in a subject. Particularly, Msx1 suppresses mTOR through a direct interaction with mTOR, resulting in the inhibition of angiogenesis. The Msx1 significantly suppresses tumor angiogenesis that is necessary for the growth, invasion, and metastasis of solid tumors. Ad-Msx1 can be used to effectively inhibit tumor metastasis by suppressing angiogenesis, tumor cell invasion, and migration.

Abstract: The present invention relates to a novel function of Msx1 protein for inhibiting tumor angiogenesis and metastasis by targeting mTOR (mammalian target of rapamycin) signaling pathway, and for treating a cancer in a subject. Particularly, Msx1 suppresses mTOR through a direct interaction with mTOR, resulting in the inhibition of angiogenesis. The Msx1 significantly suppresses tumor angiogenesis that is necessary for the growth, invasion, and metastasis of solid tumors. Ad-Msx1 can be used to effectively inhibit tumor metastasis by suppressing angiogenesis, tumor cell invasion, and migration.