Patents by Inventor L'houcine Ouafik

L'houcine Ouafik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies that bind to adrenomedullin and to adrenomedullin receptors and the uses thereof as drugs
    Patent number: 9474794
    Abstract: The invention relates to antibodies that bind to adrenomedullin and to proteins forming adrenomedullin receptors and to the uses thereof as drugs.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: October 25, 2016
    Assignees: Universite d'Aix-Marseille, Centre National de la Recherche Scientifique
    Inventors: Kamel Mabrouk, L'Houcine Ouafik, Carine Tesic, Denis Bertin, Caroline Berenguer-Daize, Pierre-Marie Martin
  • Antibodies binding to adrenomedullin receptors and uses thereof as drugs
    Patent number: 9028818
    Abstract: The invention relates to antibodies binding to the proteins forming adrenomedullin receptors, and to the uses thereof as a drug.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: May 12, 2015
    Assignees: Universite d'Aix-Marseille, Assitance Publique Hôpitaux de Marseille
    Inventors: L'Houcine Ouafik, Kamel Mabrouk, Itidal Kaafarany, Pierre-Marie Martin
  • Diagnostic and Treatment of an Androgen-Independent Prostate Cancer
    Publication number: 20140308298
    Abstract: The present invention relates to a method for monitoring the tumor growth of an androgen-independent prostate cancer in a subject, by determining the amount of at least one adrenomedullin receptor and optionally adrenomedullin in a prostate cancer cell obtained from said subject. The present invention also relates to a pharmaceutical composition comprising an anti-adrenomedullin antagonist antibody and/or at least one anti-adrenomedullin receptor antagonist antibody for treating an androgen-independent prostate cancer.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 16, 2014
    Applicants: UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Institut National de la Sante et de la Recherche
    Inventors: Caroline Berenguer-Daize, Pierre-Marie Martin, Kamel Mabrouk, Denis Bertin, L'Houcine Ouafik
  • Antibodies that Bind to Adrenomedullin and to Adrenomedullin Receptors and the Uses Thereof as Drugs
    Publication number: 20130315912
    Abstract: The invention relates to antibodies that bind to adrenomedullin and to proteins forming adrenomedullin receptors and to the uses thereof as drugs.
    Type: Application
    Filed: August 30, 2011
    Publication date: November 28, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Kamel Mabrouk, L'Houcine Ouafik, Carine Tesic, Denis Bertin, Caroline Berenguer-Daize, Pierre-Marie Martin
  • METHOD FOR ASSESSING THE ABILITY OF A PATIENT TO RESPOND TO OR BE SAFELY TREATED BY A NUCLEOSIDE ANALOG BASED-CHEMOTHERAPY
    Publication number: 20130011392
    Abstract: The invention relates to an in vitro method for determining the ability of a patient with cancer to respond to a monochemotherapy or to a polychemotherapy involving the administration of at least one chemotherapeutic agent the liver elimination of which involves cytidine deaminase (CDA), or to be treated by at least one such chemotherapeutic agent, which method comprises determining the CDA activity in a biological sample of the patient, wherein a CDA activity above 6 U/mg of serum sample total protein is indicative of the inability of the patient to respond to the chemotherapy, a CDA activity between 1.1 U/mg and 6 U/mg of serum sample total protein is indicative of the ability of the patient to be treated by the chemotherapeutic agent when said agent is administered in the context of a monochemotherapy, and a CDA activity between 1.
    Type: Application
    Filed: November 19, 2010
    Publication date: January 10, 2013
    Applicants: Assistance Publique Hopitaux De Marseille, Universite D'Aix Marseille
    Inventors: Joseph Ciccolini, Cédric Mercier, Jean-François Seitz, Laetitia Dahan, Athanassios Iliadis, L'Houcine Ouafik
  • ANTIBODIES BINDING TO ADRENOMEDULLIN RECEPTORS AND USES THEREOF AS DRUGS
    Publication number: 20110293634
    Abstract: The invention relates to antibodies binding to the proteins forming adrenomedullin receptors, and to the uses thereof as a drug.
    Type: Application
    Filed: July 31, 2009
    Publication date: December 1, 2011
    Applicants: ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE, UNIVERSITE DE LA MEDITERRANEE (AIX-MARSEILLE II)
    Inventors: L'houcine Ouafik, Kamel Mabrouk, Itidal Kaafarany, Pierre-Marie Martin