Patents by Inventor Lajos Hofler
Lajos Hofler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11413420Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: January 24, 2020Date of Patent: August 16, 2022Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20200164174Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: ApplicationFiled: January 24, 2020Publication date: May 28, 2020Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 10543337Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: GrantFiled: August 2, 2016Date of Patent: January 28, 2020Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 9872953Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: GrantFiled: March 28, 2013Date of Patent: January 23, 2018Assignee: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Publication number: 20160339197Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.Type: ApplicationFiled: August 2, 2016Publication date: November 24, 2016Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Patent number: 9498571Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: GrantFiled: March 28, 2013Date of Patent: November 22, 2016Assignee: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Patent number: 9480785Abstract: An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.Type: GrantFiled: December 7, 2013Date of Patent: November 1, 2016Assignee: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20150073331Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: ApplicationFiled: March 28, 2013Publication date: March 12, 2015Inventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley
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Publication number: 20140294672Abstract: An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.Type: ApplicationFiled: December 7, 2013Publication date: October 2, 2014Applicant: The Regents of the University of MichiganInventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
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Publication number: 20130261537Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.Type: ApplicationFiled: March 28, 2013Publication date: October 3, 2013Applicant: The Regents of the University of MichiganInventors: Lajos Hofler, Mark E. Meyerhoff, Dipankar Koley