Abstract: Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.

Abstract: Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane comprising: providing an isocyanate; providing a chain extender; providing a peptide; and allowing the isocyanate, chain extender, and peptide to react thereby forming the peptide-modified polyurethane, as well as methods for treating a subject comprising: providing a peptide-modified polyurethane that comprises the reaction product of an isocyanate, a chain extender, and a peptide; and administering the peptide-modified polyurethane to the subject.

Abstract: Dendritic nitric oxide donors having the formula: [P]-[(A)y]x-[(NO)z]q wherein P is a core that comprises a biocompatible polymer; A is a branching unit monomer that comprises at least one end group capable of reversibly attaching NO; (NO) is nitric oxide; x, y, and z are positive integers greater than or equal to 1; and q is a positive integer greater than or equal to y, as well as medical devices and kits that comprise dendritic nitirc oxide donors, are provided. Also provided are methods of delivering nitric oxide into a recipient subject comprising: providing a dendritic nitric oxide donor; and administering the dendritic nitric oxide donor into the recipient subject, such that the dendritic nitric oxide donor releases NO in the recipient subject.