Abstract: Provided is an adjuvant composition comprising a glycoarchaeol and at least one immunostimulantselected from a Toll-like receptor (TLR) agonist and a saponin. The glycoarchaeol and/orimmunostimulant may be present as a pharmaceutically acceptable salt. The adjuvant compositionmay be comprised together with an antigen in an immunogenic composition, such as a vaccine composition, which may be for use to induce an immune response in a subject. Further provided isuse of the immunogenic composition to induce an immune response in a subject, particularly animmune response that comprises both a cell-mediated response and a humoral response.

Abstract: A method for depositing a metal layer on a component includes applying an electrically conductive coating composition comprising a resin and metal particles on a coating region of the component and partially curing the resin to a gel state to form an electrically conductive coating. The method also includes applying additional metal particles to the partially cured resin in the gel state and depositing, via an electrodeposition process, a metal layer on the electrically conductive coating.

Abstract: In some embodiments there is provided a computer-implemented method for sorting cells. The method comprises receiving data comprising measurement datapoints for a plurality of cells, selecting a subset of the measurement datapoints using a region-of-interest, classifying the selected subset of measurement datapoints, and sorting the plurality of cells based on the classifying. In some embodiments, the method further comprises clustering previously received measurement datapoints and updating the region-of-interest based on the clustering by adjusting thresholds for the measurement datapoints.

Abstract: Nickel-cobalt materials, methods of forming a nickel-cobalt material, and methods of thermally stabilizing a nickel-cobalt material are provided. A nickel-cobalt material may include a metal matrix composite with amorphous regions and crystalline regions substantially encompassed by a nanocrystalline grain structure with a grain size distribution of about 50 nanometers to about 800 nanometers, and the nanocrystalline grain structure may include widespread intragranular twinning. The metal matrix composite may have a chemical makeup that includes nickel, cobalt, and a dopant such as phosphorus and/or boron. A nickel-cobalt material may be heat treated within a first temperature zone below the onset temperature for grain growth and then within a second temperature zone above the onset temperature for grain growth in the material. Chemical composition and heat treatment may yield a thermally stabilized nickel-cobalt material.

Abstract: A method for depositing a metal layer on a component is provided. The method includes applying an electrically conductive coating composition including a resin and metal particles on a coating region of the component; at least partially curing the resin forming an electrically conductive coating; and depositing, via an electrodeposition process, a metal layer on the electrically conductive coating.

Abstract: A mixer assembly for a gas turbine engine. The mixer assembly includes a housing and a fuel injection port. The housing has a passage formed therein, and the housing includes a passage wall facing the passage. The fuel injection port is fluidly connected to a fuel source and is configured to inject a hydrocarbon fuel into the passage. At least a portion of the passage wall is a coated passage wall. The coated passage wall is (i) coated with a layer of a catalytic metal and (ii) located downstream of the fuel injection port.

Abstract: A nickel-cobalt material and component includes a thermally stabilized nickel-cobalt alloy. The nickel-cobalt alloy disclosed herein includes nanocrystalline grain structures, pinning, such as Zener pinning, and intragranular twinning. The nickel-cobalt alloy disclosed herein exhibits multiple properties including an improved fracture toughness, an increased thermal stability, and an improved ultimate tensile strength.

Abstract: Example natural speech data generation systems and methods are described. In one implementation, a natural speech data generator initiates a game between a first player and a second player and determines a scenario associated with the game. A first role is assigned to the first player and a second role is assigned to the second player. The natural speech data generator receives multiple natural speech utterances by the first player and the second player during the game.

Abstract: A nickel-cobalt material and component includes a thermally stabilized nickel-cobalt alloy. The nickel-cobalt alloy disclosed herein includes nanocrystalline grain structures, pinning, such as Zener pinning, and intragranular twinning. The nickel-cobalt alloy disclosed herein exhibits multiple properties including an improved fracture toughness, an increased thermal stability, and an improved ultimate tensile strength.

Abstract: A chimeric antigen receptor (CAR) that binds to CEACAM6, an epitope or fragment thereof, or a variant thereof.

Abstract: A nickel-cobalt material and method of forming includes forming a doped nickel-cobalt precursor material. The method also includes heat treating the doped nickel-cobalt precursor material, wherein the heat treating includes at least heating within a temperature zone below the onset temperature for grain growth in the doped nickel-cobalt precursor material.

Abstract: Example natural speech data generation systems and methods are described. In one implementation, a natural speech data generator initiates a game between a first player and a second player and determines a scenario associated with the game. A first role is assigned to the first player and a second role is assigned to the second player. The natural speech data generator receives multiple natural speech utterances by the first player and the second player during the game.

Abstract: Nickel-cobalt materials, methods of forming a nickel-cobalt material, and methods of thermally stabilizing a nickel-cobalt material are provided. A nickel-cobalt material may include a metal matrix composite with amorphous regions and crystalline regions substantially encompassed by a nanocrystalline grain structure with a grain size distribution of about 50 nanometers to about 800 nanometers, and the nanocrystalline grain structure may include widespread intragranular twinning. The metal matrix composite may have a chemical makeup that includes nickel, cobalt, and a dopant such as phosphorus and/or boron. A nickel-cobalt material may be heat treated within a first temperature zone below the onset temperature for grain growth and then within a second temperature zone above the onset temperature for grain growth in the material. Chemical composition and heat treatment may yield a thermally stabilized nickel-cobalt material.

Abstract: The present invention is directed to composite nanoparticles comprising a metal, a rare earth element, and, optionally, a complexing ligand. The invention is also directed to composite nanoparticles having a core-shell structure and to processes for preparation of composite nanoparticles of the invention.

Abstract: A nickel-cobalt material and method of forming includes forming a doped nickel-cobalt precursor material. The method also includes heat treating the doped nickel-cobalt precursor material, wherein the heat treating includes at least heating within a temperature zone below the onset temperature for grain growth in the doped nickel-cobalt precursor material.

Abstract: A synthetic charged glycolipid is described comprising a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone of an archaeal core lipid via a beta linkage. The synthetic charged glycolipids include compounds of formula I wherein n is 0 or 1; R is hydrogen or hydroxyl; and Y is hydrogen or a sulfate group, at least one Y being a sulfate group; and including pharmaceutically acceptable salts thereof. The sulfated glycolipid produces stable archaeosomes at a mol % ratio of from 100:0 to 30:70 (sulfated glycolipid:uncharged glycolipid) and which induce a protective immune response, including CD8+ and CD4+ T cell responses. Archaeosomes comprising the sulfated glycolipids described have desirable adjuvant properties, particularly when mixed with uncharged glycolipid at a mol % ratio of about 50:50.

Abstract: Modified non-human mammalian hepatoma cell lines that express hepatitis C virus (HCV) antigens and which are capable of generating tumours in a syngeneic animal model are provided. The cell lines are generated by genomic integration of an expression construct that comprises one or more HCV antigen-encoding sequences under the control of a constitutive promoter. The expression construct further comprises a selectable marker and a reporter gene under the control of the same promoter. The cell lines are useful for testing prophylactic and therapeutic vaccines against HCV either in vitro or in vivo.

Abstract: A method is disclosed for incorporating preferences of a human occupant into an autonomous driving experience. The method may include a computer system autonomously controlling speed and steering of a vehicle. While it is controlling the vehicle, the computer system may interpret a speech command received from a human occupant of the vehicle. The computer system may determine whether changing at least one of the speed and steering in accordance with the speech command would be safe and legal. If it would be safe and legal, the computer system may change the at least one of the speed and steering in accordance with the speech command. If it would not be safe and legal, the computer system may leave the at least one of the speed and steering unchanged in contravention of the speech command.

Abstract: The present invention is directed to composite nanoparticles comprising a metal, a rare earth element, and, optionally, a complexing ligand. The invention is also directed to composite nanoparticles having a core-shell structure and to processes for preparation of composite nanoparticles of the invention.

Abstract: A method is disclosed for incorporating preferences of a human occupant into an autonomous driving experience. The method may include a computer system autonomously controlling speed and steering of a vehicle. While it is controlling the vehicle, the computer system may interpret a speech command received from a human occupant of the vehicle. The computer system may determine whether changing at least one of the speed and steering in accordance with the speech command would be safe and legal. If it would be safe and legal, the computer system may change the at least one of the speed and steering in accordance with the speech command. If it would not be safe and legal, the computer system may leave the at least one of the speed and steering unchanged in contravention of the speech command.