Patents by Inventor Lance F.Bentley TAMMERO

Lance F.Bentley TAMMERO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for threshold determination in multiplexed assays
    Patent number: 8762068
    Abstract: Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: June 24, 2014
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Lance F. Bentley Tammero, John M. Dzenitis, Benjamin J. Hindson
  • Data transformation methods for multiplexed assays
    Patent number: 8494780
    Abstract: Methods to improve the performance of an array assay are described. A correlation between fluorescence intensity-related parameters and negative control values of the assay is determined. The parameters are then adjusted as a function of the correlation. As a result, sensitivity of the assay is improved without changes in its specificity.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: July 23, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Lance F. Bentley Tammero, John M. Dzenitis, Benjamin J. Hindson
  • DATA TRANSFORMATION METHODS FOR MULTIPLEXED ASSAYS
    Publication number: 20110022344
    Abstract: Methods to improve the performance of an array assay are described. A correlation between fluorescence intensity-related parameters and negative control values of the assay is determined. The parameters are then adjusted as a function of the correlation. As a result, sensitivity of the assay is improved without changes in its specificity.
    Type: Application
    Filed: February 2, 2010
    Publication date: January 27, 2011
    Inventors: Lance F. Bentley TAMMERO, John M. Dzenitis, Benjamin J. Hindson
  • METHODS FOR THRESHOLD DETERMINATION IN MULTIPLEXED ASSAYS
    Publication number: 20110021368
    Abstract: Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
    Type: Application
    Filed: October 28, 2009
    Publication date: January 27, 2011
    Inventors: Lance F.Bentley TAMMERO, John M. DZENITIS, Benjamin J. HINDSON