Patents by Inventor Lance K. Gordon

Lance K. Gordon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
    Patent number: 4644059
    Abstract: A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, is prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.
    Type: Grant
    Filed: January 16, 1985
    Date of Patent: February 17, 1987
    Assignee: Connaught Laboratories, Inc.
    Inventor: Lance K. Gordon
  • Polysaccharide exotoxoid conjugate vaccines
    Patent number: 4619828
    Abstract: A water-soluble covalent polysaccharide-antigen conjugate having a molecular size between 140,000 and 4,500,000 dalton and a nominal polysaccharide/protein ratio between 0.25 and 2, capable of producing T-cell dependent antibody response to polysaccharide from a number of pathogenic bacterial organisms is prepared by mixing T-cell dependent antigen with an electrophilically activated polysaccharide hapten which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: October 28, 1986
    Assignee: Connaught Laboratories, Inc.
    Inventor: Lance K. Gordon
  • Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
    Patent number: 4496538
    Abstract: A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.
    Type: Grant
    Filed: January 6, 1982
    Date of Patent: January 29, 1985
    Assignee: Connaught Laboratories, Inc.
    Inventor: Lance K. Gordon