Abstract: The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. 1(a)). The article is comprised of an outer layer (1) having an inner layer-facing side and an opposite side; an inner layer (3) having an outer layer-facing side and an opposite side, the inner layer (3) joined to the outer layer (1) to form one or more closed material reservoir (2) between the outer layer-facing side of the inner layer (2) and the inner layer-facing side of the outer layer (1); and adhesive (4) covering a first portion of the opposite side of the inner layer (3), wherein the adhesive (4) is a heat activated adhesive that changes color and/or is activated when the article is subjected to elevated temperatures, thereby sealing the transdermal dosage form within the article.

Abstract: The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. 1(a)). The article is comprised of an outer layer (1) having an inner layer-facing side and an opposite side; an inner layer (3) having an outer layer-facing side and an opposite side, the inner layer (3) joined to the outer layer (1) to form one or more closed material reservoir (2) between the outer layer-facing side of the inner layer (2) and the inner layer-facing side of the outer layer (1); and adhesive (4) covering a first portion of the opposite side of the inner layer (3), wherein the adhesive (4) is a heat activated adhesive that changes color and/or is activated when the article is subjected to elevated temperatures, thereby sealing the transdermal dosage form within the article.

Abstract: A blending apparatus comprises a blender including a container having a wall, the wall including a window. The container rotates about an axis of rotation. A wireless spectrometer is mounted to the container and operates through the window, in a direction that does not intersect the axis of rotation, for obtaining a set of spectroscopic data regarding the product during an operation of the blender. In addition, a method for assaying a blended product in a blender includes mounting a wireless spectrometer to the container, rotating the container about its axis of rotation so as to blend the product; operating the wireless spectrometer through a window in the container, in a direction that does not intersect the axis of rotation, to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

Abstract: An apparatus for detecting the homogeneity of a pharmaceutical mixture has a hopper for containing a mixture of two or more pharmaceutical components and that is situated within a production line of preparation of a pharmaceutical dosage form. A spectroscope is mounted to the hopper for measuring spectroscopic characteristics of the mixture, and a processing device that is not physically coupled to the spectroscope analyzes the spectroscopic characteristics of the mixture and derives information regarding the homogeneity of the mixture. The spectroscope wirelessly sends the spectroscopic characteristics to the processing device, which derives information regarding the homogeneity of the mixture. The wireless transmission of the spectroscopic characteristics can be done through infrared radiation or near infrared radiation, and the spectroscopic characteristics can be converted to digital signals prior to being transmitted.

Abstract: The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. 1(a)). The article is comprised of an outer layer (1) having an inner layer-facing side and an opposite side; an inner layer (3) having an outer layer-facing side and an opposite side, the inner layer (3) joined to the outer layer (1) to form one or more closed material reservoir (2) between the outer layer-facing side of the inner layer (2) and the inner layer-facing side of the outer layer (1); and adhesive (4) covering a first portion of the opposite side of the inner layer (3), wherein the adhesive (4) is a heat activated adhesive that changes color and/or is activated when the article is subjected to elevated temperatures, thereby sealing the transdermal dosage form within the article.

Abstract: A blending apparatus comprises a blender including a container having a wall, the wall including a window. The container rotates about an axis of rotation. A wireless spectrometer is mounted to the container and operates through the window, in a direction that does not intersect the axis of rotation, for obtaining a set of spectroscopic data regarding the product during an operation of the blender. In addition, a method for assaying a blended product in a blender includes mounting a wireless spectrometer to the container, rotating the container about its axis of rotation so as to blend the product; operating the wireless spectrometer through a window in the container, in a direction that does not intersect the axis of rotation, to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

Abstract: An apparatus for detecting the homogeneity of a pharmaceutical mixture has a hopper for containing a mixture of two or more pharmaceutical components and that is situated within a production line of preparation of a pharmaceutical dosage form. A spectroscope is mounted to the hopper for measuring spectroscopic characteristics of the mixture, and a processing device that is not physically coupled to the spectroscope analyzes the spectroscopic characteristics of the mixture and derives information regarding the homogeneity of the mixture. The spectroscope wirelessly sends the spectroscopic characteristics to the processing device, which derives information regarding the homogeneity of the mixture. The wireless transmission of the spectroscopic characteristics can be done through infrared radiation or near infrared radiation, and the spectroscopic characteristics can be converted to digital signals prior to being transmitted.