Patents by Inventor Larry D. Partain
Larry D. Partain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10022565Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.Type: GrantFiled: July 11, 2016Date of Patent: July 17, 2018Assignee: Varian Medical Systems, Inc.Inventors: Stavros Prionas, Michael C. Green, Edward Seppi, Larry D. Partain, James Clayton, Stanley Mansfield, John Boone
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Patent number: 9545526Abstract: A system and method are provided for imaging and treatment of tumorous tissue in a patient. In an embodiment, the system includes a radiation source for generating a radiation beam comprising high-energy photons with low energy distributions for high contrast imaging along with high energy distributions for efficient treatment dose delivery. The radiation source includes a charged particle accelerator that generates charged particles having energies of less than 6 megavolts (MV), a target to receive the charged particles and generate the high-energy photons of the radiation beam, and a collimator to emit the radiation beam. The system further includes an imaging device of high detective quantum efficiency to define a target region of the tumorous tissue in the patient using the radiation beam, and a controller to determine the shape and modulate the dose for treatment of the tumorous tissue based on the defined target region, using the radiation beam.Type: GrantFiled: September 11, 2014Date of Patent: January 17, 2017Inventor: Larry D. Partain
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Publication number: 20160317839Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.Type: ApplicationFiled: July 11, 2016Publication date: November 3, 2016Inventors: Stavros Prionas, Michael C. Green, Edward Seppi, Larry D. Partain, James Clayton, Stanley Mansfield, John Boone
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Patent number: 9387342Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.Type: GrantFiled: July 21, 2008Date of Patent: July 12, 2016Assignee: Varian Medical Systems, Inc.Inventors: Stavros Prionas, Michael C. Green, Edward Seppi, Larry D. Partain, James Clayton, Stanley Mansfield, John Boone
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Patent number: 9305351Abstract: Methods of determining a probability of a suspect cancer nodule being malignant are provided. In one embodiment, the method begins with tabulating histogram data of malignant and benign nodules as a function of biomarker values for a specified patient population suspect of having a specific type of cancer. Next, the tabulated histogram data is separated into a plurality of biomarker bins where the bins are ranges of biomarker values, and malignancy probability fractions are calculated for each biomarker bin by dividing a number of true positives in each marker bin by a summed total of all true and false positives in each bin. Finally, a suspect nodule in a patient is scanned, a biomarker value for the suspect nodule determined, and a malignancy probability for the suspect nodule determined by reference to the tabulated histogram data and the malignancy probability fractions. Other embodiments are also disclosed.Type: GrantFiled: June 16, 2013Date of Patent: April 5, 2016Inventor: Larry D. Partain
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Publication number: 20140369582Abstract: Methods of determining a probability of a suspect cancer nodule being malignant are provided. In one embodiment, the method begins with tabulating histogram data of malignant and benign nodules as a function of biomarker values for a specified patient population suspect of having a specific type of cancer. Next, the tabulated histogram data is separated into a plurality of biomarker bins where the bins are ranges of biomarker values, and malignancy probability fractions are calculated for each biomarker bin by dividing a number of true positives in each marker bin by a summed total of all true and false positives in each bin. Finally, a suspect nodule in a patient is scanned, a biomarker value for the suspect nodule determined, and a malignancy probability for the suspect nodule determined by reference to the tabulated histogram data and the malignancy probability fractions. Other embodiments are also disclosed.Type: ApplicationFiled: June 16, 2013Publication date: December 18, 2014Inventor: Larry D. PARTAIN
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Patent number: 8658960Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: GrantFiled: August 29, 2011Date of Patent: February 25, 2014Assignee: Varian Medical Systems, Inc.Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Publication number: 20140051992Abstract: An apparatus and method of localization of a target using in vivo markers is described. The method may include adjusting a position of a target volume within the body relative to a treatment beam using the in vivo markers.Type: ApplicationFiled: October 24, 2013Publication date: February 20, 2014Applicant: Varian Medical Systems, INC.Inventors: Hassan Mostafavi, Larry D. Partain, Alexander Sloutsky, Peter Munro
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Patent number: 8559590Abstract: A radiation system includes a first radiation source and a first detector positioned opposite to each other configured to image a body portion, and a second radiation source and a second detector positioned opposite to each other configured to image a region of interest in the body portion. The first radiation source has a first spot size and the first detector has a first pixel size. The second radiation source has a second spot size and the second detector has a second pixel size. The first spot size of the first radiation source may be different from the second spot size of the second radiation source, and/or the first pixel size of the first detector may be different from the second pixel size of the second detector.Type: GrantFiled: January 28, 2010Date of Patent: October 15, 2013Assignee: Varian Medical Systems, Inc.Inventor: Larry D. Partain
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Publication number: 20110311025Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: ApplicationFiled: August 29, 2011Publication date: December 22, 2011Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Patent number: 8049156Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: GrantFiled: November 16, 2009Date of Patent: November 1, 2011Assignee: Varian Medical Systems, Inc.Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Publication number: 20110182402Abstract: A radiation system includes a first radiation source and a first detector positioned opposite to each other configured to image a body portion, and a second radiation source and a second detector positioned opposite to each other configured to image a region of interest in the body portion. The first radiation source has a first spot size and the first detector has a first pixel size. The second radiation source has a second spot size and the second detector has a second pixel size. The first spot size of the first radiation source may be different from the second spot size of the second radiation source, and/or the first pixel size of the first detector may be different from the second pixel size of the second detector.Type: ApplicationFiled: January 28, 2010Publication date: July 28, 2011Applicant: Varian Medical Systems, Inc.Inventor: Larry D. Partain
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Patent number: 7817774Abstract: The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.Type: GrantFiled: September 9, 2008Date of Patent: October 19, 2010Assignee: Varian Medical Systems, Inc.Inventors: Larry D. Partain, David Humber
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Publication number: 20100128839Abstract: A radiation apparatus includes a first radiation source configured to generate radiation suitable for therapeutic treatment, and a structure for supporting a body. The structure comprises a curved surface adapted to receive a body portion to be treated during a therapeutic treatment.Type: ApplicationFiled: November 21, 2008Publication date: May 27, 2010Applicant: Varian Medical Systems, Inc.Inventors: Larry D. Partain, Gary Virshup, Edward Seppi, David Humber
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Publication number: 20100118166Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: ApplicationFiled: November 16, 2009Publication date: May 13, 2010Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Publication number: 20100016649Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.Type: ApplicationFiled: July 21, 2008Publication date: January 21, 2010Applicant: VARIAN MEDICAL SYSTEMS, INC.Inventors: Stavros Prionas, Michael C. Green, Edward Seppi, Larry D. Partain, James Clayton, Stanley Mansfield, John Boone
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Patent number: 7638752Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: GrantFiled: September 5, 2008Date of Patent: December 29, 2009Assignee: Varian Medical Systems, Inc.Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Patent number: 7492858Abstract: The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.Type: GrantFiled: May 20, 2005Date of Patent: February 17, 2009Assignee: Varian Medical Systems, Inc.Inventors: Larry D. Partain, David H. Humber
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Publication number: 20080315105Abstract: A method and apparatus for excess signal compensation in an imaging system is described. In one particular embodiment, the invention provides for non-linear background, offset (due to time dependent dark current) and/or lag (including constant, linear and non-linear terms, due to image persistence) corrections of large area, flat panel imaging sensors.Type: ApplicationFiled: September 5, 2008Publication date: December 25, 2008Inventors: Larry D. Partain, Ivan Mollov, Carlo Tognina, Richard E. Colbeth
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Publication number: 20080317202Abstract: The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.Type: ApplicationFiled: September 9, 2008Publication date: December 25, 2008Applicant: Varian Medical Systems, Inc.Inventors: Larry D. Partain, David Humber