Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: A device for coordinated control and operation of double doors having a plate with a rectilinear motion that is associated with links with adjustable lengths that connect the plate to the double doors, with both the first and the second doors opened when one of the doors is opened and sequentially closed when one of the doors is closed.

Abstract: A device for coordinated control and operation of double doors having a plate with a rectilinear motion that is associated with links with adjustable lengths that connect the plate to the double doors, with both the first and the second doors opened when one of the doors is opened and sequentially closed when one of the doors is closed.

Abstract: A device for coordinated control and operation of double doors having a plate with a rectilinear motion that is associated with links with adjustable lengths that connect the plate to the double doors, with both the first and the second doors opened when one of the doors is opened and sequentially closed when one of the doors is closed.

Abstract: A device for coordinated control and operation of double doors having a plate with a rectilinear motion that is associated with links with adjustable lengths that connect the plate to the double doors, with both the first and the second doors opened when one of the doors is opened and sequentially closed when one of the doors is closed.

Abstract: Supported two handed controllers usable with video games are disclosed that include a controller body with a back, a front, a lanyard and a joining structure. The joining structures may attach to the controller body at a body joining point near the controller body center of gravity and near a controller symmetry plane such that the controller body is able to freely hang from the lanyard by the joining structure with the controller back above the controller front and with the controller at a distance from the user that is comfortable for both play and short term retention when not actively engaged in play.

Abstract: Embodiments of the invention are directed to transportable fishing rod holders. In one embodiment, a transportable fishing rod holder is defined by a frame having two opposing horizontally-oriented members with a vertically-oriented member situated therebetween. A securing mechanism secured to a bottom of the frame may be used to temporarily drive the frame into the ground by a user. A removable panel may be secured to the frame by a locking mechanism in a first position, or carrying position, and may be secured by a cantilever mechanism in a second position, or user position. The frame and/or the panel may have one or more holders to hold one or more fishing poles.