Abstract: The present invention relates to pharmaceutical compositions and combinations comprising regorafenib or its hydrate, solvate, metabolite or pharmaceutically acceptable salt or a polymorph thereof and a PD-1/PD-L1(2) inhibitor for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.

Abstract: The present invention relates to methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.

Abstract: The present invention relates to methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.

Abstract: The invention relates to a method and a post-operative care unit for analysing and quantifying an ultrasound tissue Doppler imaging (TDI) signal from a transducer fastened on the myocardium to obtain a parameter indicating regional cardiac ischaemia or correlates with global hypokinetic heart function. This has the advantage over manually operated probes that it can be automated and used continuously over long time. According to the method, a TDI signal trace corresponding to at least one of tissue velocity, strain or strain rate is extracted and correlated with an electrocardiogram to define subsections within a cardiac cycle in the extracted trace corresponding to the early systolic phase and the post-systolic phase. Then, a velocity, strain or strain rate is read in at least the post-systolic phase of the extracted trace, and a parameter which is a function of one of these readings and which indicates ischaemia or global hypokinetic function is generated.

Abstract: The invention relates to an identification chip for insertion in an object located in a liquid. The identification chip comprises an acoustic resonator (100), which exhibits a number of distinct resonant frequencies, where the combination of resonant frequencies is unique to the identification chip. This enables the identification chip to be identified by exposing it to an acoustic polling signal, measuring an acoustic response signal and analysing the frequency of the response signal. The resonator (100) comprises a cavity-forming part (110, 120) and a membrane (130). The acoustic resonant frequencies are determined by at least one cavity (140), which is enclosed by the cavity-forming part (110, 120) and the membrane (140). The identification chip can be implanted in a fish, with the object of identifying the fish when it is located in water.

Abstract: The present invention relates to a method of processing ultrasound images from a subject preadministered with an ultrasound contrast agent wherein quantitative measures of the contrast enhancement pattern of said lymph nodes are generated. The lymphatic system is made of vessels or ducts that begin in tissues and are designed to carry lymph fluid to local lymph nodes where the fluid is filtered and processed and sent to the next lymph node down the line until the fluid reaches the thoracic duct where it enters the blood stream. Lymph fluid which enters the lymph vessels carries with it substances and materials from the tissue, e.g. antigens, particles and cells. The lymph nodes process the lymph fluid by sieving it and macrophages inside the nodes remove particulate and cell material carried by the lymph fluid via phagocytosis.

Abstract: The invention relates to an identification chip for insertion in an object located in a liquid. The identification chip comprises an acoustic resonator (100), which exhibits a number of distinct resonant frequencies, where the combination of resonant frequencies is unique to the identification chip. This enables the identification chip to be identified by exposing it to an acoustic polling signal, measuring an acoustic response signal and analysing the frequency of the response signal. The resonator (100) comprises a cavity-forming part (110, 120) and a membrane (130). The acoustic resonant frequencies are determined by at least one cavity (140), which is enclosed by the cavity-forming part (110, 120) and the membrane (140). The identification chip can be implanted in a fish, with the object of identifying the fish when it is located in water.

Abstract: Ultrasound measurement of bone quality using nonlinear analysis in combination with or alternatively using shear waves provide improved information about human bone conditions. Surface waves also provide a novel method to estimate shear wave velocity.

Abstract: Ultrasound measurement of bone quality using nonlinear analysis in combination with or alternatively using shear waves provide improved information about human bone conditions. Surface waves also provide a novel method to estimate shear wave velocity.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Abstract: Ultrasound measurement of bone quality using nonlinear analysis in combination with or alternatively using shear waves provide improved information about human bone conditions. Surface waves also provide a novel method to estimate shear wave velocity.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilized by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Abstract: A method of measuring tissue perfusion in a human or non-human animal subject which comprises administering an effective amount of an ultrasound contrast agent to said subject, irradiating tissue in a target region with at least one pulse of ultrasound having energy sufficient to destroy or discernibly modify the echogenic properties of substantially all contrast agent in said target region, and ultrasonically detecting and quantifying the rate of flow of either further contrast agent into said target region or modified contrast agent out of said target region.

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.

Abstract: A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37° C., at least one component of said mixture being a halocarbon having a molecular weight of at least 100.

Abstract: Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualize the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.