Abstract: The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (T) where A, B, R1, X1, X2, and W are described herein.

Abstract: The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

Abstract: The present invention relates to a method and device for determining a level of ventilatory assist to a ventilator-dependent patient, in which a critical threshold of a respiration-related feature is calculated. Fatigue of a respiratory muscle of the ventilator-dependent patient develops when the critical threshold is reached by the respiration-related feature. The level of ventilatory assist to the ventilator-dependent patient is controlled in relation to the critical threshold of the respiration-related feature so as to prevent fatigue of the patient's respiratory muscle.

Abstract: A method and device for filtering an input signal containing wanted signal components and unwanted signal components, wherein the signal is modeled as a set of polynomials. Polynomials from the set are identified to model the unwanted signal components. These unwanted signal components are removed from the input signal by removing the polynomials identified as modeling the unwanted signal components from the set of polynomials to thereby leave in the input signal only the wanted signal components. According to an alternative, polynomials from the set are identified to model the wanted signal components, and the polynomials identified as modeling the wanted signal components are outputted as an estimate of the wanted signal components substantially free from the unwanted signal components. According to another aspect, a weighting factor indicative of signal strength is determined for each polynomial and these weighting factors are summed to provide an estimate of the strength of the input signal.

Abstract: Described is an electrode array for measuring electrical activity in a subject's biological tissue, comprising an electrode support, a group of electrodes mounted on the electrode support, and an inter-electrode conductive medium having a given resistivity for controlling resistivity between the electrodes of the group. Also, described is a method for controlling the inter-electrode resistivity in the electrode array comprises providing the inter-electrode conductive medium having the given resistivity between the electrodes of the group, and interconnecting the electrodes of the group through this inter-electrode conductive medium to control resistivity between the electrodes.

Abstract: A method and device for filtering an input signal containing wanted signal components and unwanted signal components, wherein the signal is modeled as a set of polynomials. Polynomials from the set are identified to model the unwanted signal components. These unwanted signal components are removed from the input signal by removing the polynomials identified as modeling the unwanted signal components from the set of polynomials to thereby leave in the input signal only the wanted signal components. According to an alternative, polynomials from the set are identified to model the wanted signal components, and the polynomials identified as modeling the wanted signal components are outputted as an estimate of the wanted signal components substantially free from the unwanted signal components. According to another aspect, a weighting factor indicative of signal strength is determined for each polynomial and these weighting factors are summed to provide an estimate of the strength of the input signal.

Abstract: A method and system for producing higher quality electromyogram (EMG) signals utilizes an array of electrodes for sensing a plurality of EMG signals in an electrically active region of a subject's muscle. A weighting function is applied to the EMG signals to produce weighted signals. This weighting function contains correction features for the relative locations of the center of the electrically active region and the electrodes. The quality of the weighted EMG signals is evaluated, and the weighted signals or sum or mean of the weighted signals whose evaluated quality is insufficient are replaced. A sum or mean of a feature of the weighted signals is calculated to produce a higher quality electromyocardiographic signal. The method and system can also be used to determine signal strength or frequency contents of a signal falling outside the array of electrodes.

Abstract: Described is an electrode array for measuring electrical activity in a subject's biological tissue, comprising an electrode support, a group of electrodes mounted on the electrode support, and an inter-electrode conductive medium having a given resistivity for controlling resistivity between the electrodes of the group. Also, described is a method for controlling the inter-electrode resistivity in the electrode array comprises providing the inter-electrode conductive medium having the given resistivity between the electrodes of the group, and interconnecting the electrodes of the group through this inter-electrode conductive medium to control resistivity between the electrodes.

Abstract: To control a lung ventilator comprising an inspiratory implement to be worn by the patient, an air supply system for supplying air to the inspiratory implement, and a control unit for controlling the air supply system, electromyographic signals produced by the patient's diaphragm are detected by an array of electrodes passing through the center of the patient's diaphragm depolarizing region. The position of the center of the patient's diaphragm depolarizing region is determined through detection of a reversal of polarity of the electromyographic component of the electrode-detected electromyographic signals.

Abstract: In the method and system for electromyographic analysis of a striated muscle, electromyographic signals produced by the muscle are detected by means of an array of electrodes passing through the center of the muscle depolarizing region. Each electromyographic signal comprises an electromyographic component and a noise component. The position of the center of the muscle depolarizing region is then determined by detecting a reversal of polarity of the electromyographic components of the signals. Finally, two signals of opposite polarities amongst the electromyographic signals are subtracted. The subtraction subtracts the noise components of the two signals from each other but adds the electromyographic components of the two signals together to produce an electromyographic signal of improved signal-to-noise ratio.

Abstract: For controlling a work process carried out by means of a robot (RB), instructions are stored both relating to the positioning of the robot and relating to the very process to be accomplished. The process instructions are stored in the form of process stage instructions (SPS, SPM and SPE) comprising(a) process start stage, during which the process is initiated (the arc is struck, for instance, when arc welding is involved) and the relative movement between object and robot can be started;(b) process main stage, during which the actual process is carried out; and, at least when the process is not directly followed by a further process;(c) process terminal stage, during which the process is terminated (the arc is broken, for instance, when arc welding is involved) and the relative movement between object and robot can be stopped.

Abstract: Apparatus for handling elongated objects such as pieces of wood includes at least one elongated flexible member for forming the bottom and sides of an object-handling compartment having a longitudinal dimension and a transverse dimension, the flexible member having a first end and a free end; a coiling device associated with the first end of the flexible member for winding up and unwinding the flexible member; an attaching device at the free end of the flexible member; an attaching mechanism operable for selectively being connected to and disconnected from the attaching device whereby when the attaching device and the attaching mechanism are connected, the flexible member can be suspended from its ends to form the compartment and whereby the attaching device can be disconnected from the attaching mechanism to loosen the flexible member to enable emptying of the compartment; and a device arranged after loosening of the flexible member to introduce the flexible member in the attaching mechanism so as to bring t