Patents by Inventor Lars Winther
Lars Winther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240001268Abstract: A system and a method for filtering a predetermined molecule entrained as a 3D-complex in a liquid comprising a filter forming solid all forming a filter forming suspension, the system having a filter chamber into which the filter forming suspension is fed and drained to form a filter with inclusions of the 3D-complex, where after a cleansing liquid is fed to a neighbouring liquid chamber and fed evenly through the filter to cleanse the filter and subsequently dissolve the complex to retrieve the product or target molecule.Type: ApplicationFiled: December 13, 2021Publication date: January 4, 2024Inventors: Jan Kyhse-Andersen, Lars Winther
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Publication number: 20230338480Abstract: The present invention relates to a safe and efficient system to improve haemostatic control by immobilization of Tissue Factor protein to a dressing material suitable for use as or in a wound dressing, bringing Tissue Factor in direct contact to the wound. The present invention aims at using immobilized Tissue Factor to generate a “thrombin burst”, a process by which thrombin, the most important constituent of the coagulation cascade is released very rapidly. There is no systemic release of the protein Tissue Factor into the vascular bed. The linked protein Tissue Factor can be used alone or in combination with other human proteins or components to optimise haemostasis.Type: ApplicationFiled: September 16, 2021Publication date: October 26, 2023Inventors: Lars Winther, Peter Aadal Nielsen, Kurt Baekgaard Osther, Charlotte Videbaek
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Publication number: 20220048010Abstract: Ligand functionalized substrate including a solid substrate, which has been modified to provide grafted catching ligand groups covalently bound via a linker, methods of preparing the ligand functionalized substrate and the use thereof, such as to increase binding rate and the dynamic binding capacity (DBC).Type: ApplicationFiled: December 17, 2019Publication date: February 17, 2022Inventors: Jan Kyhse-Andersen, Lars Winther, Jerald Rasmussen
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Patent number: 10183969Abstract: The present invention relates to a process for purification of a target molecule, comprising the steps: (a) contacting a target molecule, and a population of target binding polypeptides (TBP), in solution for a sufficient time to allow complex formation; and (b) isolating the target from the complex from (a) by subsequent purification steps, wherein (i) the target binding polypeptides have at least two binding functionalities; a first binding functionality towards the target and a second binding functionality towards a catching ligand comprised in a solid support; and (ii) the first binding functionality comprises at least two binding sites for the target, and the target comp¬ rises at least two binding sites for the TBP.Type: GrantFiled: May 4, 2010Date of Patent: January 22, 2019Assignee: CHRETO ApSInventors: Jan Kyhse-Andersen, Lars Winther
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Patent number: 10036066Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats.Type: GrantFiled: March 17, 2015Date of Patent: July 31, 2018Assignee: DAKO DENMARK A/SInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Publication number: 20160273035Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats.Type: ApplicationFiled: March 17, 2015Publication date: September 22, 2016Applicant: DAKO DENMARK A/SInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Patent number: 9340824Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g.Type: GrantFiled: April 14, 2014Date of Patent: May 17, 2016Assignee: DAKO Denmark A/SInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Publication number: 20160054300Abstract: We disclose a reference standard for a detectable entity, the reference standard comprising a support medium, preferably an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a biological, preferably cellular compact particle, preferably a cellular compact particle. We also disclose a reference standard for a detectable entity, the reference standard comprising a support medium, preferably an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a non-biological compact particle, preferably a non-cellular compact particle having cell-like dimensions, preferably less than 1.5 mm.Type: ApplicationFiled: November 14, 2014Publication date: February 25, 2016Inventors: Lars Winther, Kurt Pll
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Publication number: 20150329617Abstract: Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs.Type: ApplicationFiled: March 13, 2002Publication date: November 19, 2015Applicants: DYNAL BIOTECH ASA, DAKO A/SInventors: Lars Winther, Lars Oestergaard Petersen, Soeren Buus, Joergen Schoeller, Erik Ruud, Oeystein Aamellem
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Patent number: 9133507Abstract: An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.Type: GrantFiled: December 13, 2013Date of Patent: September 15, 2015Assignee: DAKO DENMARK A/SInventors: Gregory A. Testa, Tim Svenstrup Poulsen, Steen Hauge Matthiesen, Ole Feldballe Rasmussen, Lars Winther
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Patent number: 9017992Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats.Type: GrantFiled: June 30, 2006Date of Patent: April 28, 2015Assignee: Dako Denmark A/SInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Patent number: 8969087Abstract: There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.Type: GrantFiled: September 6, 2012Date of Patent: March 3, 2015Assignee: Dako Denmark A/SInventors: Loren L. Bland, Marc E. Key, Lars Winther, David A. Stanforth, Martin N. Lindberg
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Publication number: 20150031071Abstract: A system and method for distributing and agitating an amount of a liquid over a microscope slide, wherein a distribution plate having a microtextured lower surface and at least one passage extending through the plate is secured at a predetermined distance of 10-250 ?m above the microscope slide. Liquid passes through the passage in the distribution plate, and the distribution plate is transversely reciprocated relative to the microscope slide in the plane of the lower surface of the distribution plate or the plane of the upper surface of the microscope slide.Type: ApplicationFiled: March 1, 2013Publication date: January 29, 2015Applicant: Victorious Medical Systems ApSInventor: Lars Winther
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Publication number: 20140315204Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (THC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g.Type: ApplicationFiled: April 14, 2014Publication date: October 23, 2014Applicant: DAKO DENMARK A/SInventors: LARS WINTHER, JESPER LOHSE, Susanne GABS, Kenneth Heesche PETERSEN
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Publication number: 20140286838Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: Lars Winther, Marc Key, Kristopher Buchanan, John Favuzzi, Benno Guggenheimer
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Publication number: 20140273088Abstract: A method, an automated apparatus and a system for staining of a plurality of biological samples arranged on slides, e.g. for histological and cytological examination. A patient case having slides arranged in a frame is loaded into the apparatus, in which pre-treatment, including e.g. drying, baking, dewaxing and target retrieval, as well as staining, is carried out differently in respect of the slides in accordance with predetermined or operator-specified treatment protocols.Type: ApplicationFiled: October 12, 2012Publication date: September 18, 2014Inventor: Lars Winther
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Patent number: 8784735Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.Type: GrantFiled: August 12, 2013Date of Patent: July 22, 2014Assignee: Dako Denmark A/SInventors: Lars Winther, Marc Key, Kristopher Buchanan, John Favuzzi, Benno Guggenheimer
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Patent number: 8741566Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybrid.Type: GrantFiled: June 30, 2006Date of Patent: June 3, 2014Assignee: Dako Denmark A/SInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Publication number: 20140099631Abstract: An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.Type: ApplicationFiled: December 13, 2013Publication date: April 10, 2014Inventors: Gregory A. TESTA, Tim Svenstrup POULSEN, Steen Hauge MATTHIESEN, Ole FELDBALLE, Lars WINTHER
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Patent number: 8632994Abstract: The invention relates to methods and compositions of detecting a biological marker in a sample. In certain embodiments, the methods and compositions comprise a first binding agent that specifically binds to a biological marker in a sample; a second binding agent linked to a first polymer, wherein the second binding agent specifically binds to the first binding agent; a third binding agent linked to a second polymer, wherein the third binding agent specifically binds to the second binding agent; and a detectable substance. In certain embodiments the biological markers are detected immunologically.Type: GrantFiled: November 30, 2004Date of Patent: January 21, 2014Assignee: Dako Denmark A/SInventors: Lars Winther, Anthony Lionel Knoll, Kellyann Weckworth, Uffe Lovborg