Abstract: Sensor laminates for detection by immunoassay of target molecules in biological fluids wherein the sensor laminates contain a reactive substrate layer having a polymeric material treated to enhance binding to a ligand and methods of producing and using these sensor laminates are provided. Also provided are multi-sectioned fluid delivery devices for use with the sensor laminates in detection of target molecules in biological fluids.

Abstract: Intercutaneous implant devices useful in intraluminal and extraluminal procedures for externalization of vessels are provided which have a hollow cylinder with an upper and lower end and an interior and exterior surface, said hollow cylinder having a central aperture which is greater in diameter than the exterior expanse of the access site and a length which provides for adequate annular separation of the externalized vessel at the exterior and interior surface of the implant to ensure adequate blood supply to the vessel; a flange extending from the upper end of the hollow cylinder which provides a platform onto which is attached a termination device; and a plane contacting surface extending from the lower end of the hollow cylinder which provides a means for fixation of the implant to the patient.