Patents by Inventor Laszlo Czollner

Laszlo Czollner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8476315
    Abstract: The present invention encompasses novel triterpene compounds of general formula I, wherein R3a, R3b, R11a, R11b, R31 and R32 are defined as in claim 1, which are suitable for the prevention and/or treatment of diseases mediated by 11 ?-HSD and the use thereof for preparing a medicament having the above-mentioned properties.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: July 2, 2013
    Assignee: Onepharm Research & Development GmbH
    Inventors: Paul Kosma, Ulrich Jordis, Dirk Classen-Houben, Bernhard Kueenburg, Christian Stanetty, Laszlo Czollner
  • Publication number: 20120022154
    Abstract: The present invention encompasses novel triterpene compounds of general formula I, wherein R3a, R3b, R11a, R11b, R31 and R32 are defined as in claim 1, which are suitable for the prevention and/or treatment of diseases mediated by 11 ?-HSD and the use thereof for preparing a medicament having the above-mentioned properties.
    Type: Application
    Filed: March 10, 2010
    Publication date: January 26, 2012
    Applicant: ONEPHARM RESEARCH & DEVELOPMENT GMBH
    Inventors: Dirk Classenhouben, Bernhard Kueenburg, Paul Kosma, Ulrich Jordis, Christian Stanetty, Laszlo Czollner
  • Publication number: 20080188522
    Abstract: The invention relates to a method for producing an acid addition salt of 2,4?-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of the formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxolane in the presence of an acid serving as a catalyst, and the tolperisone obtained in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.
    Type: Application
    Filed: April 4, 2008
    Publication date: August 7, 2008
    Applicant: SANOCHEMIA PHARMAZEUTIKA AG
    Inventors: Laszlo Czollner, Beate Kalz, Jan Rothenburger, Stefan Welzig
  • Patent number: 7385060
    Abstract: The invention relates to a method for producing an addition salt of 2,4?-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I).
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: June 10, 2008
    Assignee: Sanochemia Pharmazeutika AG
    Inventors: Laszlo Czollner, Beate Kälz, Jan Rothenburger, Stefan Welzig
  • Publication number: 20070105837
    Abstract: The invention relates to novel derivatives of 4a,5,9,10,11,12-hexahydro-benzofuro[3a,3,2] [2]benzazepine of general formulae 1a, 1b and 1c. Compounds 1a, 1b and 1c can be produced in an efficient manner on an industrial scale with the desired optical purity and are suitable for the production of medicaments for the treatment of a diverse range of symptoms, particularly diseases of the central nervous system (CNS), on account of the pharmacological effect thereof.
    Type: Application
    Filed: September 9, 2004
    Publication date: May 10, 2007
    Inventors: Laszlo Czollner, Beate Kalz, Stefan Welzig, J. Frantsits, Ulrich Jordis, Johannes Frohlich
  • Publication number: 20070027138
    Abstract: New compounds of general formula I
    Type: Application
    Filed: June 28, 2006
    Publication date: February 1, 2007
    Inventors: Ulrich Jordis, Johannes Frohlich, Matthias Treu, Manfred Hirnschall, Laszlo Czollner, Beate Kalz, Stefan Welzig
  • Patent number: 7166588
    Abstract: New compounds of general formula I
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: January 23, 2007
    Assignee: Sanochemia Pharmazeutika Aktiengesellschaft
    Inventors: Ulrich Jordis, Johannes Frohlich, Matthias Treu, Manfred Hirnschall, Laszlo Czollner, Beate Kälz, Stefan Welzig
  • Patent number: 7101890
    Abstract: New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) and new compounds of the general formula (III) Drugs, containing compounds of formulas (I) and/or (III), which can be used successfully for the treatment of Alzheimer's disease and related dementia conditions, as well as for the treatment of Langdon-Down syndrome, are also described.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: September 5, 2006
    Assignee: Sanochemia Ltd.
    Inventors: Laszlo Czollner, Johannes Frohlich, Ulrich Jordis, Bernhard Kuenburg
  • Publication number: 20060111341
    Abstract: The invention relates to the use of galanthamine and the cholinergically active derivatives thereof in the production of medicaments for preventive treatment of postoperative delirium and/or subsyndronal postoperative delirium. Galanthamine, the galathamine derivative(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-methyl-4a,5,9,10-tetrahydro-6H-benzofuro[3a,3,2-ef][2]benzazepinium bromide and analogous salts, hydrates or solvates are advantageously suited for use according to the invention.
    Type: Application
    Filed: July 12, 2004
    Publication date: May 25, 2006
    Inventors: Angelika Bodenteich, Werner Frantsits, Eberhard Pirich, Laszlo Czollner
  • Publication number: 20060041141
    Abstract: The invention relates to a method for producing an addition salt of 2,4?-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxolane in the presence of an acid serving as a catalyst, and the tolperisone obtained in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.
    Type: Application
    Filed: March 31, 2003
    Publication date: February 23, 2006
    Inventors: Laszlo Czollner, Beate Kalz, Jan Rothenburger, Stefan Welzig
  • Publication number: 20040067974
    Abstract: New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) 1
    Type: Application
    Filed: August 26, 2003
    Publication date: April 8, 2004
    Applicant: SANOCHEMIA LTD.
    Inventors: Laszlo Czollner, Johannes Frohlich, Ulrich Jordis, Bernhard Kuenburg
  • Patent number: 6638925
    Abstract: New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) and new compounds of the general formula (III) Drugs, containing compounds of formulas (I) and/or (III), which can be used successfully for the treatment of Alzheimer's disease and related dementia conditions, as well as for the treatment of Langdon-Down syndrome, are also described.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: October 28, 2003
    Assignee: Sanochemia Ltd.
    Inventors: Laszlo Czollner, Johannes Frohlich, Ulrich Jordis, Bernhard Kuenburg
  • Publication number: 20030199493
    Abstract: New compounds of general formula I 1
    Type: Application
    Filed: March 18, 2002
    Publication date: October 23, 2003
    Inventors: Ulrich Jordis, Johannes Frohlich, Matthias Treu, Manfred Hirnschall, Laszlo Czollner, Beate Kalz, Stefan Welzig
  • Publication number: 20030092700
    Abstract: New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) 1
    Type: Application
    Filed: February 11, 1999
    Publication date: May 15, 2003
    Inventors: LASZLO CZOLLNER, JOHANNES FROHLICH, ULRICH JORDIS, BERNHARD KUENBURG
  • Patent number: 6407229
    Abstract: The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: June 18, 2002
    Assignee: Sanochemia Pharmazeutika AG
    Inventors: Laszlo Czollner, Johannes Fröhlich, Ulrich Jordis, Bernhard Küenburg
  • Patent number: 6369238
    Abstract: The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a, 5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: April 9, 2002
    Assignee: Sanochemia Pharmazeutica
    Inventors: Laszlo Czollner, Johannes Fröhlich, Ulrich Jordis, Bernhard Küenburg
  • Patent number: 6043359
    Abstract: The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: March 28, 2000
    Assignee: Sanochemia Pharmazeutica Aktiengesellschaft
    Inventors: Laszlo Czollner, Johannes Frohlich, Ulrich Jordis, Bernhard Kuenburg
  • Patent number: 4829076
    Abstract: The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof.The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: May 9, 1989
    Assignee: Alkaloida Vegyeszeti Gyar
    Inventors: Geza Szilagyi, Eva Bozo, Laszlo Czollner, Laszlo Jaszlits, Gyorgy Rabloczky, Jozsef Borsi, Istvan Elekes, Gyongyi Nagy nee Csokas, Andras Varro, ZSuzanne Lang nee Rihmer, Gyorgy Cseh, Gyula Horvath, Ilona Bodi