Abstract: A system, a method, and a computer program product for identifying candidates for a clinical study are disclosed. A subject matter query for a study is received. Based on the received subject matter query, a group of potential candidates for participating in the study is ascertained. The subject matter query is received at a federated data repository system storing heterogeneous data. The federated data repository system translates the subject matter query and based on the translated subject matter query, the group of potential candidates is ascertained.

Abstract: Provided herein are methods for preparing a microbiome sample for transplantation into a subject in need thereof. In particular, the methods and compositions relate to methods of repopulating the the microbiome of a subject in the treatment of gastrointestinal maladies e.g., diarrhea and/or constipation.

Abstract: Fluorinated compounds and methods of making fluorinated compounds are described herein.

Abstract: Fluorinated compounds and methods of making fluorinated compounds are described herein.

Abstract: Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity. These methods and compositions can be used in the prevention or treatment of AD.

Abstract: The invention provides methods for the alteration of fertility in plants through modulation of floral GABA levels. The techniques of the invention may find use in plant breeding techniques. Also provided by the invention are assays for the screening of candidate modulators of GABA metabolism or GABA analogs through the identification of affects on fertility following application of the candidate modulator to a plant. The technique provides an alternative to animal testing and is amenable to large scale application.

Abstract: Carbohydrate usage in the gastro-intestinal tract of a subject can be modulated by administering, to a subject, a first agent that inhibits carbohydrate degradation in combination with a second agent that decreases formation or severity of intestinal gas.

Abstract: The invention provides methods for the alteration of fertility in plants through modulation of floral GABA levels. The techniques of the invention may find use in plant breeding techniques. Also provided by the invention are assays for the screening of candidate modulators of GABA metabolism or GABA analogs through the identification of affects on fertility following application of the candidate modulator to a plant. The technique provides an alternative to animal testing and is amenable to large scale application.