Abstract: A removable insole for insertion into footwear, includes a lower layer made of a viscoelastic gel and including a lower surface, an upper surface, a toe portion, a heel portion and a medial arch portion interconnecting the toe portion and the heel portion, a first recess formed in the lower surface of the toe portion and a second recess formed in the lower surface of the heel portion, each recess having a peripheral side wall and a top wall, a plurality of thin, parallel, spaced apart sinusoidal wave shaped spring walls formed from the viscoelastic gel and connected to the top wall and the peripheral side wall in each recess, and the spring walls having lower edges generally coplanar with a lower surface of the toe portion and heel portion which is in surrounding relation to the respective recess; and a top cover secured to the upper surface of the lower layer.

Abstract: A removable ball of the foot insert for placement into footwear at a position in correspondence with a forefoot portion of the footwear includes a substantially planar member made from a viscoelastic gel, the planar member including a lower surface and an upper surface, and a plurality of spring walls formed from a viscoelastic gel and extending from the lower surface of the planar member at a predetermined area corresponding to a ball of the foot when the insert is inserted into the footwear, for separating bones of second and third metatarsals of the foot, the spring walls having heights that generally decrease outwardly from a center of the predetermined area, and the viscoelastic gel of the planar member having a hardness greater than a hardness of the viscoelastic gel of the spring walls.

Abstract: A removable ball of the foot insert for placement into footwear at a position in correspondence with a forefoot portion of the footwear includes a substantially planar member made from a viscoelastic gel, the planar member including a lower surface and an upper surface, and a plurality of parallel, spaced apart, sinusoidally shaped spring walls formed from a viscoelastic gel and extending from the lower surface of the planar member at a predetermined area corresponding to a ball of the foot when the insert is inserted into the footwear, for separating bones of second and third metatarsals of the foot, the spring walls having heights that generally decrease outwardly from a center of the predetermined area, and the viscoelastic gel of the planar member having a hardness greater than a hardness of the viscoelastic gel of the spring walls.

Abstract: A removable insole for insertion into footwear, includes a lower layer made of a viscoelastic gel and including a lower surface, an upper surface, a toe portion, a heel portion and a medial arch portion interconnecting the toe portion and the heel portion, a first recess formed in the lower surface of the toe portion and a second recess formed in the lower surface of the heel portion, each recess having a peripheral side wall and a top wall, a plurality of thin, parallel, spaced apart sinusoidal wave shaped spring walls formed from the viscoelastic gel and connected to the top wall and the peripheral side wall in each recess, and the spring walls having lower edges generally coplanar with a lower surface of the toe portion and heel portion which is in surrounding relation to the respective recess; and a top cover secured to the upper surface of the lower layer.

Abstract: An insole for use with footwear includes a first layer including a heel portion of a first thickness, a mid portion connected to a front section of the heel portion and having a substantially constant thickness which is much less than the first thickness, and having an upward curvature, an upper surface extending along the mid and heel portions and on which a person stands, and a lower surface extending along the mid and heel portions, the lower surface including a shallow recess in the mid portion, the first layer being made of a material of a first hardness; and a flexible and resilient, thin arch spring insert of a substantially constant thickness secured in the recess and following the curvature of the mid portion, the arch spring insert being made of a material of a second hardness which is greater than the first hardness.

Abstract: An insole for use with footwear includes a first layer including a heel portion of a first thickness, a mid portion connected to a front section of the heel portion and having a substantially constant thickness which is much less than the first thickness, and having an upward curvature, an upper surface extending along the mid and heel portions and on which a person stands, and a lower surface extending along the mid and heel portions, the lower surface including a shallow recess in the mid portion, the first layer being made of a material of a first hardness; and a flexible and resilient, thin arch spring insert of a substantially constant thickness secured in the recess and following the curvature of the mid portion, the arch spring insert being made of a material of a second hardness which is greater than the first hardness.

Abstract: A removable insole for insertion into footwear, includes a forefoot portion extending at least to metatarsals of a foot, the forefoot portion including a combination layer formed from a bottom layer of a resilient foam material which provides a shock absorption cushioning function, and a top layer of a slow recovery material which absorbs shear forces applied to the second layer at pressure points and spreads out the shear forces along the forefoot portion, the top layer being of substantially the same dimensions as the bottom layer and superposed therewith, the bottom and top layers having the same thickness and outer dimensions; a cupped heel portion formed by a relatively flat central portion and a sloped side wall; a mid-foot portion connecting together the forefoot portion and the heel portion, the mid-foot portion including a medial arch portion and being connected to the forefoot portion at the medial arch portion, the heel portion and mid-foot portion together being formed by a unitary layer of resili

Abstract: A removable insole for insertion into footwear, includes a forefoot portion extending at least to metatarsals of a foot, with a second recess at an undersurface thereof with a plurality of cylindrical protuberances in the recess; a cupped heel portion including a relatively flat central portion and a sloped side wall surrounding the relatively flat central portion; a mid-foot portion connecting together the forefoot portion and the heel portion, the mid-foot portion including a medial arch portion defined by an extension of the sloped side wall, the sloped side wall extends to lateral and medial sides of the mid-foot portion, and the forefoot portion, heel portion and mid-foot portion formed from a unitary resilient material; a shell that extends along an underside of the insole, the medial arch portion and the sloped side wall at the heel portion and the mid-foot portion, the shell having an opening beneath the relatively flat central portion of the cupped heel portion and a gap at a rearmost end of the shel

Abstract: An insole is described having a deep heel cup, and high medial and lateral flanges extending from said heel cup, wherein said heel cup cups the calcaneous of a foot in approximately a neutral degree of varus so that the insole does not induce locking of the midtarsal joint, and said high medial and lateral flanges extend continuously high along the medial and lateral sides of the insole substantially to the first and fifth metatarsal necks of the foot. The insole is useful for individuals with a high arch or supinated foot type.

Abstract: A novel device and method for delivering a liquid containing an active ingredient to a treatment site on the skin is disclosed. The device is useful for treating lesions or abnormal skin features such as corns, warts, calluses, bunions, actinic keratoses and hard hyperkeratotic skin as is often found on the face, arms, legs or feet.

Abstract: A method of isolating and purifying galactose oxidase from a fungus media is disclosed. The supernatant liquid from the fermentation broth is subjected to ultrafiltration and then separated on a carboxy-sulfon cation exchange column using high performance liquid chromatography. Copper ions must be present to insure enzyme activity.

Abstract: Affinity chromatography matrixes and immobilized enzymes are provided in which the solid support is a covalently bound, non-crosslinked polyethyleneimine bonded phase.

Abstract: Affinity chromatography matrixes and immobilized enzymes are provided in which the solid support is a covalently bound, non-crosslinked polyethyleneimine bonded phase.

Abstract: A method of separating and recovering immunoglobulin G from biological fluids by liquid chromatographic or solid phase extraction processes utilizing, as the solid phase, a carboxylated form of silica gel or controlled pore glass bearing non-cross-linked covalently bound polyethylenimine functions.

Abstract: p-Nitrophenylester of succinoylaminopropyl silica gel is useful as an affinity matrix for reacting with ligand for use in affinity chromatography. The affinity matrix, upon reaction with a ligand, releases one molecule of p-nitrophenolate ion for every molecule of ligand that reacts and the solution turns yellow as the reaction occurs.