Patents by Inventor Laura Lerner

Laura Lerner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-GDF-15 ANTIBODIES
    Publication number: 20240166734
    Abstract: Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.
    Type: Application
    Filed: June 16, 2023
    Publication date: May 23, 2024
    Inventors: Lorena LERNER, Sandra ABBOTT, Ailin BAI, Ting CHEN, Maria Isabel CHIU, Qing LIU, Laura POLING, Nianjun TAO, Solly WEILER, Zhigang WENG, William M. WINSTON, JR., Jeno GYURIS
  • POLYMER-BASED COMPOSITIONS FOR EXTENDED RELEASE OF PROTEINS
    Publication number: 20160324798
    Abstract: The present application is directed to poly(orthoester)-based formulations that are effective for the sustained delivery of one or more therapeutic proteins. The formulations additionally maintain the stability and bioactivity (i.e., significantly minimize the degradation and/or aggregation) of the protein contained in the poly(orthoester) matrix during preparation, storage and release.
    Type: Application
    Filed: December 30, 2014
    Publication date: November 10, 2016
    Inventors: Han Han, Thomas B. Ottoboni, Laura Lerner
  • Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
    Patent number: 9096877
    Abstract: The present invention relates to Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and to methods of using such polypeptides for treating or preventing cancer and other diseases. The Fc region-containing polypeptides of the present invention are preferably immunoglobulins (e.g., antibodies), in which the Fc region comprises at least one amino acid substitution relative to the corresponding amino acid sequence of a wild type Fc region, and which is sufficient to attenuate post-translational fucosylation and mediate improved binding to an activating Fc receptor and reduced binding to an inhibitory Fc receptor. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by Fc?R is desired (e.g.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: August 4, 2015
    Assignee: MacroGenics, Inc.
    Inventors: Leslie S. Johnson, Godfrey Jonah Anderson Rainey, Sergey Gorlatov, Laura Lerner
  • Fc Region-Containing Polypeptides That Exhibit Improved Effector Function Due To Alterations Of The Extent Of Fucosylation, And Methods For Their Use
    Publication number: 20120219551
    Abstract: The present invention relates to Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and to methods of using such polypeptides for treating or preventing cancer and other diseases. The Fc region-containing polypeptides of the present invention are preferably immunoglobulins (e.g., antibodies), in which the Fc region comprises at least one amino acid substitution relative to the corresponding amino acid sequence of a wild type Fc region, and which is sufficient to attenuate post-translational fucosylation and mediate improved binding to an activating Fc receptor and reduced binding to an inhibitory Fc receptor. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by Fc?R is desired (e.g.
    Type: Application
    Filed: October 7, 2010
    Publication date: August 30, 2012
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Godfrey Jonah Anderson Rainey, Sergey Gorlatov, Laura Lerner