Patents by Inventor Laura M. Bohn

Laura M. Bohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Signaling-biased mu opioid receptor agonists
    Patent number: 10751335
    Abstract: The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: August 25, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Thomas D. Bannister, Laura M. Bohn, Cullen L. Schmid
  • SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS
    Publication number: 20190055214
    Abstract: The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.
    Type: Application
    Filed: March 15, 2017
    Publication date: February 21, 2019
    Inventors: Thomas D. Bannister, Laura M. Bohn, Cullen L. Schmid
  • OPIOID RECEPTOR LIGANDS
    Publication number: 20090088466
    Abstract: The invention provides novel compounds of formula (I), (II), (III), and (IV). The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to an animal in need of treatment. The invention also provides therapeutic methods for the use of compounds of formula (V), as well as methods for treating diseases by administering such compounds.
    Type: Application
    Filed: June 16, 2006
    Publication date: April 2, 2009
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Laura M. Bohn, Thomas E. Prisinzano
  • Inhibition of betaarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
    Publication number: 20030097671
    Abstract: The present invention provides a &bgr;arrestin knockout mouse useful for screening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of &bgr;arrestin to phosphorylated &mgr; opioid receptors, and methods of screening a compound for activity in potentiating &mgr; opioid receptor agonist activity (e.g., morphine activity) by determining whether or not said compound inhibits &bgr;arrestin binding to a phosphorylated &mgr; opioid receptor.
    Type: Application
    Filed: January 3, 2003
    Publication date: May 22, 2003
    Inventors: Laura M. Bohn, Fang-Tsyr Lin, Marc G. Caron, Robert J. Lefkowitz
  • Inhibition of &bgr;arrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
    Patent number: 6528271
    Abstract: The present invention provides a &bgr;arrestin knockout mouse useful for screeening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of &bgr;arrestin to phosphorylated &mgr; opioid receptors, and methods of screening a compound for activity in potentiating &mgr; opioid receptor agonist activity (e.g., morphine activity) by determining whether or not said compound inhibits &bgr;arrestin binding to a phosphorylated &mgr; opioid receptor.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: March 4, 2003
    Assignee: Duke University
    Inventors: Laura M. Bohn, Fang-Tsyr Lin, Marc G. Caron, Robert J. Lefkowitz