Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The disclosed embodiments relate to a system that includes a manifold assembly having a first drilling fluid flow path configured to enable operation of riser gas handling drilling for a mineral extraction system, where the first drilling fluid flow path has an inlet and one or more first outlets, and a second drilling fluid flow path configured to enable operation of a second drilling technique for the mineral extraction system, different from the first drilling technique, where the second drilling fluid flow path has the inlet and one or more second outlets, and where the first drilling fluid flow path and the second drilling fluid flow path are different from one another.

Abstract: A system includes a flow restrictor assembly configured to be coupled to an annular structure having a central bore. The flow restrictor assembly includes one or more adjustable segments configured to move relative to the annular structure between a retracted position in which the one or more adjustable segments do not extend into the central bore and an extended position in which the one or more adjustable segments extend into the central bore to reduce a cross-sectional flow area of the central bore by between approximately 5 to 95 percent to restrict fluid flow through the central bore.

Abstract: The disclosed embodiments relate to a system that includes a manifold assembly having a first drilling fluid flow path configured to enable operation of a first drilling technique for a mineral extraction system, where the first drilling fluid flow path has a first inlet and one or more first outlets and a second drilling fluid flow path configured to enable operation of a second drilling technique for the mineral extraction system, different from the first drilling technique, where the second drilling fluid flow path has a second inlet and one or more second outlets, and where the first drilling fluid flow path and the second drilling fluid flow path are different from one another.

Abstract: The disclosed embodiments relate to a system that includes a manifold assembly having a first drilling fluid flow path configured to enable operation of a first drilling technique for a mineral extraction system, where the first drilling fluid flow path has a first inlet and one or more first outlets and a second drilling fluid flow path configured to enable operation of a second drilling technique for the mineral extraction system, different from the first drilling technique, where the second drilling fluid flow path has a second inlet and one or more second outlets, and where the first drilling fluid flow path and the second drilling fluid flow path are different from one another.

Abstract: The disclosed embodiments relate to a system that includes a manifold assembly having a first drilling fluid flow path configured to enable operation of riser gas handling drilling for a mineral extraction system, where the first drilling fluid flow path has an inlet and one or more first outlets, and a second drilling fluid flow path configured to enable operation of a second drilling technique for the mineral extraction system, different from the first drilling technique, where the second drilling fluid flow path has the inlet and one or more second outlets, and where the first drilling fluid flow path and the second drilling fluid flow path are different from one another.

Abstract: A system includes a flow restrictor assembly configured to be coupled to an annular structure having a central bore. The flow restrictor assembly includes one or more adjustable segments configured to move relative to the annular structure between a retracted position in which the one or more adjustable segments do not extend into the central bore and an extended position in which the one or more adjustable segments extend into the central bore to reduce a cross-sectional flow area of the central bore by between approximately 5 to 95 percent to restrict fluid flow through the central bore.