Patents by Inventor Laura McCole

Laura McCole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Xylose utilization in recombinant zymomonas
    Patent number: 8679822
    Abstract: Xylose-utilizing Zymomonas strains studied were found to accumulate ribulose when grown in xylose-containing media. Engineering these strains to increase ribose-5-phosphate isomerase activity led to reduced ribulose accumulation, improved growth, improved xylose utilization, and increased ethanol production.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: March 25, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Perry G. Caimi, Laura McCole, Luan Tao, Jean-Francois Tomb, Paul V. Viitanen
  • XYLOSE UTILIZATION IN RECOMBINANT ZYMOMONAS
    Publication number: 20120156746
    Abstract: Xylose-utilizing Zymomonas strains studied were found to accumulate ribulose when grown in xylose-containing media. Engineering these strains to increase ribose-5-phosphate isomerase activity led to reduced ribulose accumulation, improved growth, improved xylose utilization, and increased ethanol production.
    Type: Application
    Filed: June 16, 2011
    Publication date: June 21, 2012
    Inventors: Perry G. Caimi, Laura McCole, Luan Tao, Jean-Francois Tomb, Paul V. Viitanen
  • Zymomonas with improved xylose utilization
    Patent number: 7998722
    Abstract: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: August 16, 2011
    Assignees: E. I. du Pont de Nemours and Company, Alliance for Sustainable Energy LLC
    Inventors: Paul V. Viitanen, Luan Tao, Yuying Zhang, Perry G. Caimi, Carol M. McCutchen, Laura McCole, Min Zhang, Yat-Chen Chou, Mary Ann Franden
  • High expression promoters
    Patent number: 7989206
    Abstract: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: August 2, 2011
    Assignee: E.I. du Pont de Nemours and Company Alliance for Sustainable Energy LLC
    Inventors: Paul V. Viitanen, Luan Tao, Yuying Zhang, Perry G. Caimi, Laura McCole, Min Zhang, Yat-Chen Chou, Carol M. McCutchen, Mary Ann Franden
  • ZYMOMONAS WITH IMPROVED XYLOSE UTILIZATION
    Publication number: 20090246846
    Abstract: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: PAUL V. VIITANEN, LUAN TAO, YUYING ZHANG, PERRY G. CAIMI, CAROL M. MCCUTCHEN, LAURA MCCOLE, MIN ZHANG, YAT-CHEN CHOU, MARY ANN FRANDEN
  • HIGH EXPRESSION ZYMOMONAS PROMOTERS
    Publication number: 20090246876
    Abstract: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: PAUL V. VIITANEN, LUAN TAO, YUYING ZHANG, PERRY G. CAIMI, LAURA MCCOLE, MIN ZHANG, YAT-CHEN CHOU, CAROL M. MCCUTCHEN, MARY ANN FRANDEN