Patents by Inventor Laura P. Hale

Laura P. Hale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETERMINING THE SUITABILITY OF CULTURED THYMUS TISSUE FOR IMPLANTATION INTO HUMANS AND ASSOCIATED METHODS OF USE
    Publication number: 20200405771
    Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor. Methods of producing an allogeneic cultured postnatal thymus tissue-derived product suitable for implantation into a human; methods of culturing allogeneic cultured postnatal thymus tissue-derived product suitable for implantation into a human and methods of using allogeneic cultured postnatal thymus tissue-derived product by implantation in a human subject.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 31, 2020
    Inventors: Mary Louise MARKERT, Laura P. HALE, Alex TRACY, Kristin MARKS, Karin PIHEL
  • Method of modulating melanin production
    Patent number: 7803750
    Abstract: The present invention relates, in general, to melanin production and, in particular, to a method of modulating melanin production and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: September 28, 2010
    Assignee: Duke University
    Inventor: Laura P. Hale
  • Method of modulating melanin production
    Publication number: 20040241116
    Abstract: The present invention relates, in general, to melanin production and, in particular, to a method of modulating melanin production and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: July 28, 2003
    Publication date: December 2, 2004
    Applicant: DUKE UNIVERSITY
    Inventor: Laura P. Hale
  • Allogeneic cellular vaccine
    Patent number: 6503503
    Abstract: Vaccination with an allogeneic cell line modified with genetic material encoding specific protein antigens is an effective technique for the delivery of protein antigens to the host's antigen presentation system. The immune response generated by this vaccine is restricted by the major histocompatibility complex type of the host and not the vaccinating cell line. This immunization strategy may be used to treat or prevent tumors or infectious diseases of a mammal.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: January 7, 2003
    Assignee: Duke University
    Inventors: Darell D. Bigner, John H. Sampson, David M. Ashley, Laura P. Hale
  • Zinc alpha-2-glycoprotein as indicator of cancer
    Publication number: 20020155514
    Abstract: The present invention relates, in general, to methods of diagnosing and monitoring cancer and inflammatory diseases/disorders and, in particular, to methods of diagnosing and monitoring cancer and inflammatory diseases/disorders that comprise assaying for elevated levels of zinc alpha-2-glycoprotein (ZAG) in serum and other body fluids. The invention also relates to methods of inhibiting thymic atrophy, including tumor-associated atrophy.
    Type: Application
    Filed: December 3, 2001
    Publication date: October 24, 2002
    Inventors: Laura P. Hale, David T. Price
  • Device lithography using multi-level resist systems
    Patent number: 4532005
    Abstract: In order to hard-bake the bottom resist layer of a tri-level resist system for patterning a device wafer, the resist is subjected to a positive ramp heating step (of increasing ambient temperatures).
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: July 30, 1985
    Assignee: AT&T Bell Laboratories
    Inventors: Michael J. Grieco, Laura P. Hale