Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: Razors cartridges including a guard, a cap, and at least two blades with parallel sharpened edges located between the guard and cap are provided. The first blade has a first color and a second blade has a second color, where the first color is different than the second color. The blade color corresponds to an attribute of the blade (e.g., low cut force) that the color is disposed on or an attribute of the razor cartridge (e.g., sensitive skin). The color of the blade corresponds to a target user of the razor cartridge (e.g., male or female). The first blade defines a blade edge near or nearest the guard and a second blade defines a blade edge near or nearest the cap.

Abstract: A method for providing an administration policy to a user device comprising a plurality of applications, the method comprising centrally generating the administration policy to be implemented in the user device, the administration policy comprising at least one of an application administration policy to be used by at least one of the plurality of applications and a client administration policy for the user device; and providing the generated policy to the user device.

Abstract: Apparatus for x-ray CT scanning of an object includes an x-ray generator 1 mounted on a first support 3 on an outer ring 4 and an x-ray detector 2 mounted on a second support 10 on an inner ring 11, and a drive mechanism arranged to rotate the outer and inner rings 4, 11. The outer and inner rings have a first common axis of rotation and the diameter of the outer ring 4 is greater than the diameter of the inner ring 11 The drive mechanism includes a gearing arrangement connecting the outer and inner rings 4,11. The gearing arrangement comprises first and second toothed rotary gears 14,16.

Abstract: Provided herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for providing interactive exploration and analysis of cellular environments represented within MIF images. An embodiment includes a pipeline configured to generate an interactive visualization with selectable icons that represent cells in an MIF image by identifying identifying cells in the MIF image and generating a graph of the MIF image based on coordinates and the properties of the identified cells, with each node in the graph corresponding to the cells as well as neighboring cells. The graph may be transformed into embeddings and generating an interactive visualization of the graph based on the embeddings. Selectable icons in the interactive visualization correspond to nodes in the graph.

Abstract: Disclosed are nucleic acid oligomer compounds and to their use in compositions and methods for inhibiting proliferation, survival or viability of cancer cells including prostate, lung, pancreatic, breast, cervical and bone cancer cells.

Abstract: Catalyst compositions, methods of making catalysts, and methods of conducting Fischer-Tropsch (FT) reactions are described. It has been discovered that a combination of large crystallite size and high porosity results in catalysts and FT catalyst systems with high stability and low methane selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a bare catalyst support material with an aqueous solution or dispersion of one or more titanium metal sources and one or more carboxylic acids; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: The present disclosure relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support.

Abstract: The present disclosure relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support.

Abstract: The invention relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support. A first aspect is the modification of the silica support with at least 11 wt % titania to prevent the formation of cobalt silicates, thereby limiting the deactivation resulting from the silicate formation. A second aspect is the provision of C03O4 particles highly dispersed on the catalyst support with an average particle diameter of the cobalt oxide particle of less than 12 nm in order to improve catalytic activity and selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminum metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: Catalyst compositions, methods of making catalysts, and methods of conducting Fischer-Tropsch (FT) reactions are described. It has been discovered that a combination of large crystallite size and high porosity results in catalysts and FT catalyst systems with high stability and low methane selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminium metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: The disclosed invention relates to a process for conducting a Fischer-Tropsch reaction, comprising flowing a reactant mixture comprising fresh synthesis gas and tail gas in a microchannel reactor in contact with a catalyst to form at least one hydrocarbon product, the catalyst being derived from a catalyst precursor comprising cobalt and a surface modified catalyst support.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a bare catalyst support material with an aqueous solution or dispersion of one or more titanium metal sources and one or more carboxylic acids; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: The invention relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support. A first aspect is the modification of the silica support with at least 11 wt % titania to prevent the formation of cobalt silicates, thereby limiting the deactivation resulting from the silicate formation. A second aspect is the provision of C03O4 particles highly dispersed on the catalyst support with an average particle diameter of the cobalt oxide particle of less than 12 nm in order to improve catalytic activity and selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminium metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: The disclosed invention relates to a process for conducting a Fischer-Tropsch reaction, comprising flowing a reactant mixture comprising fresh synthesis gas and tail gas in a microchannel reactor in contact with a catalyst to form at least one hydrocarbon product, the catalyst being derived from a catalyst precursor comprising cobalt and a surface modified catalyst support.