Patents by Inventor Laurel Sillerud
Laurel Sillerud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230201380Abstract: After a stroke the temporal course of microglial/macrophage activation is biphasic. The initial phase promotes neuroinflammation, while the later phase aids neurovascular recovery. Therefore the dynamics of stroke-induced cerebral microglial/macrophage activation are of substantial interest. In one embodiment, the present invention is directed to the use of novel anti-Iba-1-targeted superparamagnetic FePt nanoparticles immunocelles in conjunction with magnetic resonance imaging (MRI) to measure the spatiotemporal course of the activation of microglia/macrophages in brain tissue at 7, 14, and 28 days post-stroke. Ischemic cerebral lesion areas are identified using T2-weighted MR images. After injection of FePt nanoparticles as immunocelles, quantitative contrast changes in T2*-weighted MR images showed that the nanoparticles were taken up solely in brain regions that coincided with areas of microglial/macrophage activation detected by post-mortem immunohistochemistry.Type: ApplicationFiled: May 26, 2021Publication date: June 29, 2023Inventors: Laurel Sillerud, Yi Yang
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Patent number: 10827946Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.Type: GrantFiled: August 31, 2016Date of Patent: November 10, 2020Assignee: UNM Rainforest InnovationsInventors: Shihoko Kimura-Ohba, Laurel Sillerud
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Patent number: 10466326Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.Type: GrantFiled: May 13, 2016Date of Patent: November 5, 2019Assignee: STC. UNMInventor: Laurel Sillerud
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Publication number: 20180249926Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.Type: ApplicationFiled: August 31, 2016Publication date: September 6, 2018Applicant: STC.UNMInventors: Shihoko Kimura-Ohba, Laurel Sillerud
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Publication number: 20180143278Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.Type: ApplicationFiled: May 13, 2016Publication date: May 24, 2018Applicant: STC.UNMInventor: Laurel Sillerud
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Patent number: 9958516Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: GrantFiled: March 26, 2014Date of Patent: May 1, 2018Assignees: ABQMR, Inc., Sandia Corporation, STC.UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Patent number: 9194921Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: GrantFiled: December 17, 2012Date of Patent: November 24, 2015Assignees: STC.UNM, Sandia Corporation, ABQMR, Inc.Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Patent number: 9110068Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.Type: GrantFiled: June 6, 2014Date of Patent: August 18, 2015Assignee: The Regents of the University of New MexicoInventor: Laurel Sillerud
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Patent number: 9110067Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.Type: GrantFiled: March 14, 2014Date of Patent: August 18, 2015Assignee: The Regents of the University of New MexicoInventor: Laurel Sillerud
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Publication number: 20140295486Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: ApplicationFiled: March 26, 2014Publication date: October 2, 2014Applicant: STC.UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Publication number: 20140287436Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid, when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.Type: ApplicationFiled: June 6, 2014Publication date: September 25, 2014Inventor: Laurel Sillerud
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Publication number: 20140273005Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventor: Laurel Sillerud
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Patent number: 8698494Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: GrantFiled: February 25, 2013Date of Patent: April 15, 2014Assignee: STC.UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Patent number: 8384381Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: GrantFiled: March 9, 2010Date of Patent: February 26, 2013Assignee: STC . UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Patent number: 8339135Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: GrantFiled: August 21, 2007Date of Patent: December 25, 2012Assignee: STC.UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Publication number: 20120112744Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.Type: ApplicationFiled: January 20, 2012Publication date: May 10, 2012Inventors: Andrew F. McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
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Patent number: 8143896Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use. In certain embodiments, the invention provides a module including a microcoil possessing an inner diameter of between 25 microns and 550 microns, a conduit disposed proximate to the microcoil, in which the conduit is in fluid communication with a sample reservoir, an affinity column in fluid communication with the conduit and the sample reservoir, and a connector for connecting the module to a magnetic resonance detector.Type: GrantFiled: October 23, 2008Date of Patent: March 27, 2012Assignees: ABQMR, Inc., NanoMR, Inc.Inventors: Andrew F McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
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Publication number: 20100219824Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.Type: ApplicationFiled: March 9, 2010Publication date: September 2, 2010Applicant: STC.UNMInventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
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Publication number: 20090146658Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.Type: ApplicationFiled: October 23, 2008Publication date: June 11, 2009Applicants: ABQMR, INC., NANOMR, INC.Inventors: Andrew F. McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
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Publication number: 20060140871Abstract: Paramagnetic or superparamagnetic nanoparticle-ligand conjugates that include a recognition ligand that interacts with a component on the surface of a prostate cancer cell. Nanoparticle-ligand conjugates of the invention may be used for magnetic resonance imaging of prostate cancer, or for treatment of tumors by targeted thermal ablation.Type: ApplicationFiled: November 30, 2005Publication date: June 29, 2006Inventor: Laurel Sillerud