Patents by Inventor Laurence Graindorge
Laurence Graindorge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10307328Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.Type: GrantFiled: February 9, 2015Date of Patent: June 4, 2019Assignees: SORIN CRM SAS, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ RENNES 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10299984Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 28, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292897Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM—INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292898Abstract: A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉDE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10251809Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.Type: GrantFiled: February 9, 2015Date of Patent: April 9, 2019Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 9504835Abstract: Devices and methods for providing pacing in multiple modes are provided. One device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode (10) with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (10-18) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or (20) forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.Type: GrantFiled: September 9, 2014Date of Patent: November 29, 2016Assignee: SORIN CRM SASInventor: Laurence Graindorge
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Publication number: 20160158091Abstract: The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20160158092Abstract: The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20160158093Abstract: The disclosure relates to a device including a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 9353145Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.Type: GrantFiled: October 9, 2012Date of Patent: May 31, 2016Assignee: ZACH SYSTEMInventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
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Publication number: 20160113571Abstract: The invention relates to an active implantable medical device. The device measures for respiratory activity and for detection of a ventilation rate fall event below a predetermined threshold. The device analyzes in real time the various parameters of the ventilation rate fall event and determines whether they satisfy predefined criteria, so as to allocate or not a priori hypopnea suspicion indicator to the event. An anti-hypopnea therapy is selectively triggered on detection of respiratory collapse, but only in the case of current events indicating a priori hypopnea suspicion. The criteria may include: history of intervals between successive events constituting hypopnea episodes; severity of the current event; conformity of a current event profile with a reference profile; physiological, obstructive or central, origin of the event; patient's current sleep stage; and history of the degree of efficacy of the therapies.Type: ApplicationFiled: October 26, 2015Publication date: April 28, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20150224017Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.Type: ApplicationFiled: February 9, 2015Publication date: August 13, 2015Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20150224018Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller.Type: ApplicationFiled: February 9, 2015Publication date: August 13, 2015Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20140379040Abstract: Devices and methods for providing pacing in multiple modes are provided. One device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode (10) with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (10-18) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or (20) forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Applicant: SORIN CRM S.A.S.Inventor: Laurence Graindorge
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Patent number: 8874212Abstract: A device produces at least two distinct temporal components (Vbip, Vuni) from two separate endocardial electrogram EGM signals concurrently collected in the same cavity. A 2D non-temporal characteristic is determined from the variations of one of the temporal components (Vuni) versus the other (Vbip). The analysis of this characteristic allows detection of the possible presence of an anodal stimulation, causing a depolarization in a second cavity after stimulation delivered to a first heart chamber, opposite to the first. One possibility is to proceed by observing whether the non-temporal 2D characteristic is included or not within a predetermined domain defined in a coordinate frame corresponding to the space of the two temporal components.Type: GrantFiled: December 13, 2013Date of Patent: October 28, 2014Assignee: Sorin CRM S.A.S.Inventors: Marie-Anne Euzen, Elodie Vincent, Laurence Graindorge
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Patent number: 8874210Abstract: An implantable cardiac prosthesis device conducting an analysis of a patient tolerance to a pacing mode favoring the spontaneous atrioventricular conduction is disclosed. The device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode (10) with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (10-18) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or (20) forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.Type: GrantFiled: June 11, 2010Date of Patent: October 28, 2014Assignee: Sorin CRM SASInventor: Laurence Graindorge
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Publication number: 20140256932Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.Type: ApplicationFiled: October 9, 2012Publication date: September 11, 2014Applicant: ZACH SYSTEMInventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
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Publication number: 20140172037Abstract: A device produces at least two distinct temporal components (Vbip, Vuni) from two separate endocardial electrogram EGM signals concurrently collected in the same cavity. A 2D non-temporal characteristic is determined from the variations of one of the temporal components (Vuni) versus the other (Vbip). The analysis of this characteristic allows detection of the possible presence of an anodal stimulation, causing a depolarization in a second cavity after stimulation delivered to a first heart chamber, opposite to the first. One possibility is to proceed by observing whether the non-temporal 2D characteristic is included or not within a predetermined domain defined in a coordinate frame corresponding to the space of the two temporal components.Type: ApplicationFiled: December 13, 2013Publication date: June 19, 2014Inventors: Marie-Anne Euzen, Elodie Vincent, Laurence Graindorge
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Publication number: 20100318150Abstract: An implantable cardiac prosthesis device conducting an analysis of a patient tolerance to a pacing mode favoring the spontaneous atrioventricular conduction is disclosed. The device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode (10) with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (10-18) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or (20) forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.Type: ApplicationFiled: June 11, 2010Publication date: December 16, 2010Inventor: Laurence GRAINDORGE
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Patent number: 7251526Abstract: An active implantable medical device of the defibrillator, cardiovertor and/or antitachycardia pacemaker type having a high maximum frequency for antibradycardia stimulation. This device provides antibradycardia stimulation at a stimulation frequency that has a programmed maximum stimulation frequency. For a detected rate exceeding a given frequency threshold, the device analyzes the cardiac activity to discriminate a ventricular tachycardia or fibrillation to command in consequence an appropriate antitachycardia therapy. The maximum stimulation frequency for antibradycardia is higher than the given frequency threshold for the antitachycardia analysis, and the cardiac rhythm is analyzed to detect a particular succession of events that are likely to reveal the presence or the appearance of a ventricular tachycardia during such high antibradycardia stimulation.Type: GrantFiled: September 16, 2003Date of Patent: July 31, 2007Assignee: ELA Medical S.A.S.Inventors: Christine Henry, Laurence Graindorge