Patents by Inventor Laurence H Pearl

Laurence H Pearl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutation of DNA polymerases from archaeobacteria
    Patent number: 8557554
    Abstract: The present invention relates to a variant archaeal DNA polymerase having a modified amino acid sequence of a wild-type amino acid sequence, the modified sequence being in the amino-terminal amino acids that comprise a uracil-binding pocket in the wild-type polymerase whereby the variant polymerase has reduced affinity for uracil than the wild-type polymerase. Such variant polymerases may be usefully employed in biological assay systems such as the polymerase chain reaction.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: October 15, 2013
    Assignee: The University of Newcastle
    Inventors: Bernard Connolly, Mark Fogg, Laurence H Pearl