Patents by Inventor Laurent Provins

Laurent Provins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted alkoxypyridinyl indolsulfonamides
    Patent number: 11976056
    Abstract: The present application relates to alkoxy-substituted pyridinyl indolsulfonamides. The compounds are negative GPR17 modulators and have utility in the treatment of various GPR17 associated disorders.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: May 7, 2024
    Assignee: UCB PHARMA GMBH
    Inventors: Cecile Pegurier, Laurent Provins, Emre M. Isin, Marie Ledecq
  • Pyridinyl and pyrazinyl-(asa)indolsulfonamides
    Patent number: 11939319
    Abstract: The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 26, 2024
    Assignee: UCB PHARMA GMBH
    Inventors: Cecile Pegurier, Laurent Provins, Alvaro Cardenas, Marie Ledecq, Christa E. Mueller, Joerg Hockemeyer, Ali El-Tayeb, Nader Boshta, Mahmoud Rashed
  • Prodrugs of 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
    Publication number: 20240083925
    Abstract: The present invention relates to a prodrug of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, which prodrug is represented by formula (II).
    Type: Application
    Filed: December 16, 2021
    Publication date: March 14, 2024
    Inventors: Ali Ates, Celal Ates, Laurent Provins
  • Octahydroisoquinolinyl Derivatives
    Publication number: 20240043400
    Abstract: The present invention relates to octahydroisoquinolinyl derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.
    Type: Application
    Filed: December 1, 2021
    Publication date: February 8, 2024
    Inventors: Ali Ates, Pierre Burssens, Adrian Hall, Laurent Provins, David Skolc, Anne Valade
  • 9H-PYRROLO-DIPYRIDINE DERIVATIVES
    Publication number: 20220213103
    Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Joel Mercier, Laurent Provins, Celine Vermeiren, Yogesh Anil Sabnis
  • Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides
    Patent number: 11345662
    Abstract: Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 31, 2022
    Assignee: UCB Pharma GmbH
    Inventors: Christa E. Mueller, Cécile Pegurier, Michael Louis Robert Deligny, Ali El-Tayeb, Joerg Hockemeyer, Marie Ledecq, Joël Mercier, Laurent Provins, Nader M. Boshta, Sanjay Bhattarai, Vigneshwaran Namasivayam, Mario Funke, Lukas Schwach, Sabrina Gollos, Daniel Von Laufenberg, Anaïs Barré
  • 9H-pyrrolo-dipyridine derivatives
    Patent number: 11312716
    Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: April 26, 2022
    Inventors: Joel Mercier, Laurent Provins, Celine Vermeiren, Yogesh Anil Sabnis
  • 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives
    Patent number: 11286266
    Abstract: The present invention relates to 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: March 29, 2022
    Inventors: Hugues Chanteux, Yannick Quesnel, Claude Delatour, Laurent Provins
  • 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives
    Patent number: 11155564
    Abstract: The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 26, 2021
    Inventors: Laurent Provins, Hugues Chanteux
  • 2-OXO-1-pyrrolidinyl imidazothiadiazole derivatives
    Patent number: 11155566
    Abstract: The present invention relates to 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: October 26, 2021
    Inventors: Laurent Provins, Hugues Chanteux
  • 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives
    Patent number: 11155565
    Abstract: The present invention relates to 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 26, 2021
    Inventors: Laurent Provins, Hugues Chanteux, Yannick Quesnel
  • SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES
    Publication number: 20210214337
    Abstract: The present application relates to alkoxy-substituted pyridinyl indolsulfonamides. The compounds are negative GPR17 modulators and have utility in the treatment of various GPR17 associated disorders.
    Type: Application
    Filed: June 19, 2019
    Publication date: July 15, 2021
    Inventors: Cecile Pegurier, Laurent Provins, Emre M. Isin, Marie Ledecq
  • Pyridinyl and Pyrazinyl-(Asa)Indolsulfonamides
    Publication number: 20210206749
    Abstract: The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.
    Type: Application
    Filed: June 18, 2019
    Publication date: July 8, 2021
    Inventors: Cecile Pegurier, Laurent Provins, Alvaro Cardenas, Marie Ledecq, Christa E. Mueller, Joerg Hockemeyer, Ali El-Tayeb, Nader Boshta, Mahmoud Rashed
  • 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES
    Publication number: 20210107922
    Abstract: The present invention relates to 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Application
    Filed: May 6, 2019
    Publication date: April 15, 2021
    Inventors: Hugues Chanteux, Yannick Quesnel, Claude Delatour, Laurent Provins
  • 9H-PYRROLO-DIPYRIDINE DERIVATIVES
    Publication number: 20210047326
    Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.
    Type: Application
    Filed: January 22, 2020
    Publication date: February 18, 2021
    Inventors: Joel Mercier, Laurent Provins, Celine Vermeiren, Yogesh Anil Sabnis
  • Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
    Patent number: 10889584
    Abstract: The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: January 12, 2021
    Assignee: UCB Biopharma SRL
    Inventors: Adrian Hall, Laurent Provins, Malcolm Maccoss
  • 2-OXO-1-PYRROLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES
    Publication number: 20200399288
    Abstract: The present invention relates to 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Application
    Filed: December 4, 2018
    Publication date: December 24, 2020
    Inventors: Laurent Provins, Hugues Chanteux
  • 2-OXO-1,3-OXAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES
    Publication number: 20200231599
    Abstract: The present invention relates to 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Application
    Filed: July 5, 2018
    Publication date: July 23, 2020
    Inventors: Laurent PROVINS, Hugues CHANTEUX, Yannick QUESNEL
  • 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES
    Publication number: 20200140458
    Abstract: The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 7, 2020
    Inventors: Laurent Provins, Hugues Chanteux
  • BICYCLIC BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION
    Publication number: 20190367513
    Abstract: The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
    Type: Application
    Filed: January 23, 2018
    Publication date: December 5, 2019
    Applicant: UCB Biopharma SPRL
    Inventors: Adrian HALL, Laurent PROVINS, Malcolm MACCOSS